Wow!!
Molecular dissection of protein complexes isolated from sections of human brain www.biorxiv.org/content/10.6...
Also complimentary:
www.biorxiv.org/content/10.6...

Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization Telomerase ribonucleoprotein (RNP) synthesizes telomeric repeats at chromosome ends using a telomerase reverse transcriptase (TERT) and a telomerase RNA (hTR in humans). Previous structural work showe...

Proud to share our work where we resolved a longstanding question regarding the existence of a human telomerase dimer and provided insights into its function. Led by 3 amazing lab members in collaboration with @yiliangding.bsky.social and @rdaslab.bsky.social.
www.science.org/doi/10.1126/...

Maybe youll notice dirtier optics... we have infuse native membrane proteins in 200 mM ammonium acetate + 2xcmc DDM or other detergent every day of the week on our eclupse, and then setup bottom up runs over the weekend. We don't notice too much of an issue with IDs, but we do clean every ~3mo

Pretty cool. We've got this detergent in almost all of our native & bottom up preps. How much are you adding?

Congrats Gabe!!

Proposal:

If the administration wants to do something to show reforms to new approaches to peer review and better support for high reward research, they could double the size of the New Innovator program and let NIH and NIH-funded researchers keep working while they look at other reforms.

7/n

Behind the Paper: Corinne Lutomski on Proteoform-specific targeting in cell signaling. YouTube video by Kavli Nano

Watch Corinne Lutomski and Jack Bennett discuss their latest #publication, "Defining proteoform-specific interactions for drug targeting in a native cell signaling environment," featured in Nature Chemistry.

youtu.be/mHiB94X4aXA

Excited to share the work from this >3 year endeavor - come check it out!

Join us Dec 12 for Proteoform Thursday featuring Tarick El-Baba from Oxford Univ. showing native MS and native top-down MS of #GPCR and their involvement in human depression. #proteomics #massspec us06web.zoom.us/meeting/regi...