a person wearing a flower costume with the word aww written above it ALT: a person wearing a flower costume with the word aww written above it

That's it for #TWiNPP - check back next week to see what exciting new findings have blossomed into NPP papers 💐

Causal links among gut microbiota, immune-inflammatory and compensatory immune-regulatory systems, and schizophrenia - Neuropsychopharmacology Neuropsychopharmacology - Causal links among gut microbiota, immune-inflammatory and compensatory immune-regulatory systems, and schizophrenia

#TWiNPP

From Yang et al., evidence for a gut-brain-immune axis in the pathogensis of schizophrenia

www.nature.com/articles/s41...

Semantic encoding of trauma memories in the hippocampus among individuals with PTSD - Neuropsychopharmacology Neuropsychopharmacology - Semantic encoding of trauma memories in the hippocampus among individuals with PTSD

#TWiNPP

Cisler et al. used language modeling and fMRI to demonstrate a key role of the hippocampus in trauma-memory recall in women with PTSD

www.nature.com/articles/s41...

Regulation of the decision threshold by the locus coeruleus - Neuropsychopharmacology Neuropsychopharmacology - Regulation of the decision threshold by the locus coeruleus

#TWiNPP

From Xia et al., norepinephrine signaling in the locus coeruleus causally regulates decision thresholds, a key determinant of the speed-accuracy tradeoff

www.nature.com/articles/s41...

Sex-biased computations underlying differential set shift performance in mice - Neuropsychopharmacology Neuropsychopharmacology - Sex-biased computations underlying differential set shift performance in mice

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Glewwe et al. demonstrate that female 🐀 outperform males in a touchscreen set-shifting task, suggesting that stable choice commitment in females paradoxically enhances cognitive flexibility / @nicglewwe.bsky.social @alikwidge.bsky.social @nicolagrissom.bsky.social sky.social

Orexin signaling at the interface of sleep disturbance and PTSD - Neuropsychopharmacology Neuropsychopharmacology - Orexin signaling at the interface of sleep disturbance and PTSD

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Next up, an Early Career Commentary from Prajapati et al. propose orexin signaling as a mechanistic bridge between sleep pathology and core symptoms of PTSD

www.nature.com/articles/s41...

Identification of an intrusive-hypervigilant phenotype of posttraumatic stress symptoms with unique stress peptide and amygdala functional connectivity profiles - Neuropsychopharmacology Neuropsychopharmacology - Identification of an intrusive-hypervigilant phenotype of posttraumatic stress symptoms with unique stress peptide and amygdala functional connectivity profiles

#TWiNPP

From Clancy et al., a biologically distinct intrusive-hypervigilant phenotype of PTSD that may be relevant for precision-targeted interventions / @irosso.bsky.social

www.nature.com/articles/s41...

Visual attention is linked to temporally structured noradrenaline release in the medial prefrontal cortex - Neuropsychopharmacology Neuropsychopharmacology - Visual attention is linked to temporally structured noradrenaline release in the medial prefrontal cortex

#TWiNPP

Posselt et al show that optimal attention depends on precisely timed noradrenaline signaling

www.nature.com/articles/s41...

#TWiNPP

April showers have brought spring flowers, and by flowers, I mean a beautiful new lineup of NPP articles ready for viewing #ThisWeekInNPP 😍🌻🌷

#TWiNPP

The spectrum of bipolar disorder in older adults Neuropsychopharmacology - The spectrum of bipolar disorder in older adults

This recent review highlights how late-life bipolar disorder is marked by disproportionate cognitive impairment & medical comorbidity that drive functional decline, underscoring the need for age-adjusted clinical strategies 🧠

Longitudinal neurocognitive trajectories in a large cohort of youth who use cannabis: combining self-report and toxicology Neuropsychopharmacology - Longitudinal neurocognitive trajectories in a large cohort of youth who use cannabis: combining self-report and toxicology

The latest data from our lab is published in @npp-journal.bsky.social today: Longitudinal neurocognitive trajectories in a large cohort of youth who use cannabis

Read the full paper here: rdcu.be/feh8B

The association between cannabis use and brain reward anticipation: a 12-month longitudinal study of adults and adolescents who use cannabis and age-matched controls Neuropsychopharmacology - The association between cannabis use and brain reward anticipation: a 12-month longitudinal study of adults and adolescents who use cannabis and age-matched controls

In a longitudinal study, the authors link cannabis use to blunted reward anticipation signaling, a neural pattern associated with addiction and anhedonia 🧠 / Matt Wall

Brain scan can reveal the risk of psychiatric hospitalization One in four psychiatric patients in Denmark are readmitted and that carries major personal and societal costs. But can we predict who will be readmitted, while others return to everyday life without s...

NPP in the News: Check out bit.ly/41FNQSd "Brain scan can reveal the risk of psychiatric hospitalization" highlighting a recently published @npp-journal.bsky.social manuscript, which can be found at: rdcu.be/fd0Ch

This recent work explores heterogeneity in suicide risk among individuals with late-life depression; while early-life and emotion regulation factors distinguished early-onset risk, social & cognitive factors distinguished late-onset risk 🧠

Prolonged grief disorder in later life: advancing our understanding of biopsychosocial mechanisms to guide future personalized interventions Neuropsychopharmacology - Prolonged grief disorder in later life: advancing our understanding of biopsychosocial mechanisms to guide future personalized interventions

This recent review discusses prolonged grief disorder (PGD) occurring in a subset of bereaved individuals and identifies older adults as a high-risk group with substantial downstream impacts on health, cognition & mortality 🧠

Clinical staging and profiling of affective disorders Neuropsychopharmacology - Clinical staging and profiling of affective disorders

In this recent review, the authors discuss whether clinical staging in affective disorders can improve outcome prediction and guide more precise treatment allocation 💊

...and if you're looking for another platform to browse #TWiNPP and other @npp-journal.bsky.social media, we are now on @linkedin.com, so please check us out:

www.linkedin.com/in/neuropsyc...

The role of ovarian hormones in risk aversion in female rats Neuropsychopharmacology - The role of ovarian hormones in risk aversion in female rats

Loss of ovarian hormones ⬆️ risk-taking in ♀️🐀, while estradiol restored risk aversion; estradiol signaling was mediated by estrogen receptor alpha, identifying a potential mechanism by which ovarian hormones regulate risk-related decision-making

a man in a suit and tie is smiling and says see you next time ALT: a man in a suit and tie is smiling and says see you next time

That's all for #TWiNPP - check back next week for another lineup of the latest and greatest in neuropsychopharmacology research 💫

#TWiNPP

Yoon and Dulawa review circuit-specific targets for developing treatments for anorexia nervosa

www.nature.com/articles/s41...

Vitamin A deficiency induces sex-specific reward processing alterations through a dysregulation of the mesolimbic dopamine transmission in mice - Neuropsychopharmacology Neuropsychopharmacology - Vitamin A deficiency induces sex-specific reward processing alterations through a dysregulation of the mesolimbic dopamine transmission in mice

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From Couty et al., disrupted retinoic acid signaling during development alters dopamine circuit function and reward processing in adulthood

www.nature.com/articles/s41...

Trajectories of late-life depression: insights from molecular imaging - Neuropsychopharmacology Neuropsychopharmacology - Trajectories of late-life depression: insights from molecular imaging

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This review from @sophie_e_holmes and Smith highlights findings from molecular imaging studies revealing widespread alterations in the brain that may contribute to cognitive decline and elevated risk of dementia in late-life depression

www.nature.com/articles/s41...

We're back with another roundup of what's new #ThisWeekInNPP 🤩

See below for the latest in neural contributions to dementia risk, the impact of vitamin A deficiency on DA function in development, and circuit-specific treatment targets for anorexia nervosa 👇

#TWiNPP

The role of brain health and resilience in reshaping trajectories of late-life neuropsychiatric disorders Neuropsychopharmacology - The role of brain health and resilience in reshaping trajectories of late-life neuropsychiatric disorders

In this recent review, the authors propose integration of cognitive and emotional resilience, stress-related physiology, and brain reserve within a lifespan framework to support prevention-focused, personalized approaches to late-life mental health 🧠

Multiple sources of β2*-nicotinic acetylcholine receptor binding are differentially affected during tobacco smoking abstinence as revealed by Independent Component Analysis of [18F]Flubatine PET image... Neuropsychopharmacology - Multiple sources of β2*-nicotinic acetylcholine receptor binding are differentially affected during tobacco smoking abstinence as revealed by Independent Component...

Be sure to check out the full article from @nakulraval.bsky.social & team 👇

npp's "Meet the Author" Interview with Dr. Nakul Raval YouTube video by NPP Journal

Our latest 'Meet the Author' interview is out 🎙️

Dr. Nakul Raval (@nakulraval.bsky.social) discusses his recent @npp-journal.bsky.social publication exploring the sources of β2*-nicotinic AChR binding during tobacco smoking abstinence using ICA of [18F]Flubatine PET images 🚬

New paper alert: @nicglewwe.bsky.social connects the explore exploit tradeoff to cognitive flexibility!!

A fun paradox: Female mice in our lab do "better" at this cognitive flexibility task because they commit to exploit behavior sooner

In @npp-journal.bsky.social
www.nature.com/articles/s41...

That's it for this week! Stay tuned for next week's edition of #TWiNPP 🫰

Finally, in response to Runia et al., Saelens et al. defend that assumptions in network meta-analyses (e.g., transitivity) were adequately tested and did not bias comparisons across TRD treatments

www.nature.com/articles/s41...