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Parksandrec Aubreyplaza GIF ALT: Parksandrec Aubreyplaza GIF

That's it for #TWiNPP - happy March 31st!

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amar ojha (@amarojha.bsky.social) neuroscientist interested in brain development, affective + cognitive control, and precision psychiatry

#TWiNPP

Last but not least, from Ojha et al., findings show that puberty-related changes in mesocorticolimbic functional connectivity are associated with reward and punishment sensitivity differently in male and female early adolescents

@cdladouceur.bsky.social @amarojha.bsky.social

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A ketogenic diet reduces hepatic alcohol metabolism and alcohol consumption in rats - Neuropsychopharmacology Neuropsychopharmacology - A ketogenic diet reduces hepatic alcohol metabolism and alcohol consumption in rats

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From Elvig and McGinn et al., a ketogenic diet reshapes liver alcohol processing and brain energetics and may be a potential modulator of alcohol-related behaviors

www.nature.com/articles/s41...

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Rethinking the “olfactory” tubercle: a hedonic hotspot within ventral striatum - Neuropsychopharmacology Neuropsychopharmacology - Rethinking the “olfactory” tubercle: a hedonic hotspot within ventral striatum

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Next up, a Research Highlight on a paper from Murata & Berridge describing the olfactory tubercle as an active node within ventral striatal reward circuitry

www.nature.com/articles/s41...

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Synaptic dysfunction and adaptation after NMDA receptor ablation in the mouse medial prefrontal cortex - Neuropsychopharmacology Neuropsychopharmacology - Synaptic dysfunction and adaptation after NMDA receptor ablation in the mouse medial prefrontal cortex

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Dick et al. demonstrate that NMDA receptor knockdown during adolescence drives dynamic, compensatory synaptic remodeling, providing insight into prefrontal cortical circuit adaptations relevant to schizophrenia

@nicolagrissom.bsky.social

www.nature.com/articles/s41...

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Tomorrow is April Fool's Day, but we'd only consider you a fool if you don't check out what's new #ThisWeekInNPP

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a woman is holding an oscar trophy and saying thank you so much to the academy ALT: a woman is holding an oscar trophy and saying thank you so much to the academy

That's all for #TWiNPP - if you ask us, they're all winners! 🏆

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Continued progress and innovation at Neuropsychopharmacology (NPP) - Neuropsychopharmacology Neuropsychopharmacology - Continued progress and innovation at Neuropsychopharmacology (NPP)

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Finally, an Editorial from our co-principal editors Drs. Tony George and Lisa Monteggia the journal's evolving strategy to strengthen its impact in psychiatric neuroscience

www.nature.com/articles/s41...

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Exposome and mental health across the lifespan: research and clinical perspectives - Neuropsychopharmacology Neuropsychopharmacology - Exposome and mental health across the lifespan: research and clinical perspectives

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Next up, a Perspective from Barzilay and Jeste highlight the exposome framework as a method for capturing the cumulative impact of environmental exposure on mental health across the lifespan

www.nature.com/articles/s41...

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Triazole 187 is a biased KOR agonist that suppresses itch without sedation and induces anxiolytic-like behaviors in mice - Neuropsychopharmacology Neuropsychopharmacology - Triazole 187 is a biased KOR agonist that suppresses itch without sedation and induces anxiolytic-like behaviors in mice

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Volf et al. demonstrate in 🐀 that Triazole 187, a biased KOR agonist, could potentially treat chronic itch and anxiety with minimal side effects

www.nature.com/articles/s41...

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Leveraging the genetics of psychiatric disorders to prioritize potential drug targets and compounds - Neuropsychopharmacology Neuropsychopharmacology - Leveraging the genetics of psychiatric disorders to prioritize potential drug targets and compounds

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Parker et al. investigate the genetics of several psychiatric disorders, highlighting shared and distinct drug targets for further development // @nadineparker.bsky.social

www.nature.com/articles/s41...

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Investigational drugs in PTSD - Neuropsychopharmacology Neuropsychopharmacology - Investigational drugs in PTSD

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Next, a review from Obi and Ressler on emerging pharmacological strategies for PTSD

www.nature.com/articles/s41...

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Sex-specific neural activation to stress and alcohol cues in high-risk drinkers: links between orbitofrontal circuits, alcohol craving, and future drinking - Neuropsychopharmacology Neuropsychopharmacology - Sex-specific neural activation to stress and alcohol cues in high-risk drinkers: links between orbitofrontal circuits, alcohol craving, and future drinking

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From Freeman et al., an fMRI study reveals sex-specific OFC circuits correlating with stress-induced alcohol craving, suggesting distinct neurobiological pathways underlying alcohol use disorder risk in men and women @drrajitastress.bsky.social

www.nature.com/articles/s41...

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#TWiNPP

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There are Oscar winners, and then there #ThisWeekInNPP features - which is more prestigious? 🤔 I'll let you decide 🏆

See below for the latest on the neurobiology alcohol use disorder risk, novel pharmacological strategies for PTSD, and so much more #TWiNPP 👇

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Hedonic hotspot in rat olfactory tubercle: map for mu-opioid, orexin, and muscimol enhancement of sucrose ‘liking’ - Neuropsychopharmacology Neuropsychopharmacology - Hedonic hotspot in rat olfactory tubercle: map for mu-opioid, orexin, and muscimol enhancement of sucrose ‘liking’

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From Murata & Berridge, subregions of the olfactory tubercle contribute to modulating hedonic reactions to sweetness and flavor perception in 🐀

www.nature.com/articles/s41...

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Escalation of cocaine consumption: tolerance versus sensitization of incentive salience - Neuropsychopharmacology Neuropsychopharmacology - Escalation of cocaine consumption: tolerance versus sensitization of incentive salience

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In this research highlight, Kawa & Robinson discuss evidence that escalation of cocaine intake is more driven by sensitization of incentive salience, providing insight into early development of addiction vulnerability 📈

www.nature.com/articles/s41...

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Maternal immune activation in mice recapitulates features of attention-deficit/hyperactivity disorder (ADHD) in susceptible offspring - Neuropsychopharmacology Neuropsychopharmacology - Maternal immune activation in mice recapitulates features of attention-deficit/hyperactivity disorder (ADHD) in susceptible offspring

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From Schaer et al., prenatal exposure to maternal immune activation in 🐭 reflects key features of ADHD in a susceptible subset of offspring

www.nature.com/articles/s41...

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The association between cannabis use and brain reward anticipation: a 12-month longitudinal study of adults and adolescents who use cannabis and age-matched controls - Neuropsychopharmacology Neuropsychopharmacology - The association between cannabis use and brain reward anticipation: a 12-month longitudinal study of adults and adolescents who use cannabis and age-matched controls

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In a longitudinal study, Skumlien et al. link cannabis use to blunted reward anticipation signaling, a neural pattern associated with addiction and anhedonia 🧠 / @mattwall.bsky.social

www.nature.com/articles/s41...

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Comparing affective bias modification by first- and second-generation antidepressants in male rats using a translational behavioural task - Neuropsychopharmacology Neuropsychopharmacology - Comparing affective bias modification by first- and second-generation antidepressants in male rats using a translational behavioural task

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Kamenish et al. demonstrate that different antidepressants modify affective biases through distinct mechanisms, which may contribute to variability in clinical onset and efficacy 💊

www.nature.com/articles/s41...

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Risk calculation circuit abnormalities plus psychosocial risk variables predict problematic substance use in youth with externalizing disorders - Neuropsychopharmacology Neuropsychopharmacology - Risk calculation circuit abnormalities plus psychosocial risk variables predict problematic substance use in youth with externalizing disorders

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Mattey-Mora et al. show that integrated neurobiological and environmental models better predict adolescent risk for substance use disorders in a longitudinal study 🧠 / @joeyaloimdphd.bsky.social

www.nature.com/articles/s41...

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Sensorimotor circuit connectivity as a candidate biomarker for responsiveness to sertraline in obsessive–compulsive disorder - Neuropsychopharmacology Neuropsychopharmacology - Sensorimotor circuit connectivity as a candidate biomarker for responsiveness to sertraline in obsessive–compulsive disorder

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From Bai et al., resting-state connectivity in the sensorimotor circuit may serve as a candidate biomarker of SSRI response in OCD 💊

www.nature.com/articles/s41...

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The neurobiological cravings signature (NCS) as a predictive neuromarker of clinical outcomes in alcohol use disorder - Neuropsychopharmacology Neuropsychopharmacology - The neurobiological cravings signature (NCS) as a predictive neuromarker of clinical outcomes in alcohol use disorder

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Lofberg et al. evaluate the neurobiological cravings signature (NCS), an fMRI-based machine learning marker, as a predictor of outcomes in alcohol use disorder 🧠 / @neuroip.bsky.social

www.nature.com/articles/s41...

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The clocks may have changed this weekend (at least in North America) 🕓 but one thing always remains constant - another stellar lineup of NPP articles is here 🤩 #ThisWeekInNPP

#TWiNPP

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That's all for this for #TWiNPP - see you the same time, same place, next week (and every week after)

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Pharmacotherapy of major depressive disorder in older adults: from an evidence-informed stepwise algorithm to precision medicine Neuropsychopharmacology - Pharmacotherapy of major depressive disorder in older adults: from an evidence-informed stepwise algorithm to precision medicine

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A review from Lenze et al., focuses on an evidence-informed stepwise algorithm for approaching precision pharmacotherapy for late-life depression (LLD) 💊

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Transcriptional profiles of antidepressant resistance across the corticolimbic pathway of chronically stressed mice Neuropsychopharmacology - Transcriptional profiles of antidepressant resistance across the corticolimbic pathway of chronically stressed mice

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Gyles et al. use a 🐭 model of treatment-resistant MDD (TRD) & RNA sequencing to reveal transcriptional signatures associated with antidepressant treatment / Angélica Torres-Berrío, PhD @sinaibrain.bsky.social Eric Nestler Eric Parise

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Task-guided accelerated cTBS simultaneously treats depression and social dysfunction in patients with major depressive disorder: a randomized clinical trial Neuropsychopharmacology - Task-guided accelerated cTBS simultaneously treats depression and social dysfunction in patients with major depressive disorder: a randomized clinical trial

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From Jin et al., an individualized task-guided accelerated continuous theta burst stimulation strategy targeting the right dorsolateral prefrontal cortex shows efficacy in alleviating depressive and anxiety symptoms while improving social dysfunction in MDD 🧠

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We're back with another run down of what's new #ThisWeekInNPP

See below for the latest on continuous theta burst stimulation, transcriptional signatures from a mouse model of TRD, and a precision pharmacotherapy for late-life depression 👇

#TWiNPP

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And that's a wrap for this week!

Join us next Tuesday for the next installment of This Week in NPP #TWiNPP

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