That's it for #TWiNPP - happy March 31st!
#TWiNPP
Last but not least, from Ojha et al., findings show that puberty-related changes in mesocorticolimbic functional connectivity are associated with reward and punishment sensitivity differently in male and female early adolescents
@cdladouceur.bsky.social @amarojha.bsky.social
#TWiNPP
From Elvig and McGinn et al., a ketogenic diet reshapes liver alcohol processing and brain energetics and may be a potential modulator of alcohol-related behaviors
www.nature.com/articles/s41...
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Next up, a Research Highlight on a paper from Murata & Berridge describing the olfactory tubercle as an active node within ventral striatal reward circuitry
www.nature.com/articles/s41...
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Dick et al. demonstrate that NMDA receptor knockdown during adolescence drives dynamic, compensatory synaptic remodeling, providing insight into prefrontal cortical circuit adaptations relevant to schizophrenia
@nicolagrissom.bsky.social
www.nature.com/articles/s41...
Tomorrow is April Fool's Day, but we'd only consider you a fool if you don't check out what's new #ThisWeekInNPP
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That's all for #TWiNPP - if you ask us, they're all winners! 🏆
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Finally, an Editorial from our co-principal editors Drs. Tony George and Lisa Monteggia the journal's evolving strategy to strengthen its impact in psychiatric neuroscience
www.nature.com/articles/s41...
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Next up, a Perspective from Barzilay and Jeste highlight the exposome framework as a method for capturing the cumulative impact of environmental exposure on mental health across the lifespan
www.nature.com/articles/s41...
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Volf et al. demonstrate in 🐀 that Triazole 187, a biased KOR agonist, could potentially treat chronic itch and anxiety with minimal side effects
www.nature.com/articles/s41...
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Parker et al. investigate the genetics of several psychiatric disorders, highlighting shared and distinct drug targets for further development // @nadineparker.bsky.social
www.nature.com/articles/s41...
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Next, a review from Obi and Ressler on emerging pharmacological strategies for PTSD
www.nature.com/articles/s41...
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From Freeman et al., an fMRI study reveals sex-specific OFC circuits correlating with stress-induced alcohol craving, suggesting distinct neurobiological pathways underlying alcohol use disorder risk in men and women @drrajitastress.bsky.social
www.nature.com/articles/s41...
There are Oscar winners, and then there #ThisWeekInNPP features - which is more prestigious? 🤔 I'll let you decide 🏆
See below for the latest on the neurobiology alcohol use disorder risk, novel pharmacological strategies for PTSD, and so much more #TWiNPP 👇
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From Murata & Berridge, subregions of the olfactory tubercle contribute to modulating hedonic reactions to sweetness and flavor perception in 🐀
www.nature.com/articles/s41...
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In this research highlight, Kawa & Robinson discuss evidence that escalation of cocaine intake is more driven by sensitization of incentive salience, providing insight into early development of addiction vulnerability 📈
www.nature.com/articles/s41...
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From Schaer et al., prenatal exposure to maternal immune activation in 🐭 reflects key features of ADHD in a susceptible subset of offspring
www.nature.com/articles/s41...
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In a longitudinal study, Skumlien et al. link cannabis use to blunted reward anticipation signaling, a neural pattern associated with addiction and anhedonia 🧠 / @mattwall.bsky.social
www.nature.com/articles/s41...
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Kamenish et al. demonstrate that different antidepressants modify affective biases through distinct mechanisms, which may contribute to variability in clinical onset and efficacy 💊
www.nature.com/articles/s41...
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Mattey-Mora et al. show that integrated neurobiological and environmental models better predict adolescent risk for substance use disorders in a longitudinal study 🧠 / @joeyaloimdphd.bsky.social
www.nature.com/articles/s41...
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From Bai et al., resting-state connectivity in the sensorimotor circuit may serve as a candidate biomarker of SSRI response in OCD 💊
www.nature.com/articles/s41...
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Lofberg et al. evaluate the neurobiological cravings signature (NCS), an fMRI-based machine learning marker, as a predictor of outcomes in alcohol use disorder 🧠 / @neuroip.bsky.social
www.nature.com/articles/s41...
The clocks may have changed this weekend (at least in North America) 🕓 but one thing always remains constant - another stellar lineup of NPP articles is here 🤩 #ThisWeekInNPP
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That's all for this for #TWiNPP - see you the same time, same place, next week (and every week after)
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A review from Lenze et al., focuses on an evidence-informed stepwise algorithm for approaching precision pharmacotherapy for late-life depression (LLD) 💊
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Gyles et al. use a 🐭 model of treatment-resistant MDD (TRD) & RNA sequencing to reveal transcriptional signatures associated with antidepressant treatment / Angélica Torres-Berrío, PhD @sinaibrain.bsky.social Eric Nestler Eric Parise
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From Jin et al., an individualized task-guided accelerated continuous theta burst stimulation strategy targeting the right dorsolateral prefrontal cortex shows efficacy in alleviating depressive and anxiety symptoms while improving social dysfunction in MDD 🧠
We're back with another run down of what's new #ThisWeekInNPP
See below for the latest on continuous theta burst stimulation, transcriptional signatures from a mouse model of TRD, and a precision pharmacotherapy for late-life depression 👇
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And that's a wrap for this week!
Join us next Tuesday for the next installment of This Week in NPP #TWiNPP