Assaying the myosin super-relaxed state across muscle types, cells and proteins for understanding muscle biology and use in drug discovery - Nature Protocols The Mant-ATP assay is a simple and accessible means for rapid quantitative assessment of the ratio of super-relaxed myosin to disordered relaxed myosin. This protocol provides a standardized methodolo...

Great collaborative work led by Christopher Toepfer and his team at the University of Oxford

bsky.app/profile/cryo...

Thick filament molecular interfaces play a critical role in pathogenesis of hypertrophic and dilated cardiomyopathy Hypertrophic (HCM) and dilated (DCM) cardiomyopathy variants in genes encoding the myosin heavy chain (MYH7), myosin light chains (MYL2 and MYL3), and cardiac myosin binding protein-C (cMyBP-C, MYBPC3...

www.biorxiv.org/content/10.1...

Annotating the X-ray diffraction pattern of vertebrate striated muscle www.biorxiv.org/content/10.1101/2025.06.11.659175v1 #cryoEM

Freeze frame: cracking molecular motion Time-resolved cryo-electron microscopy can resolve protein motion on millisecond or even microsecond timescales, but the need for highly specialized tools and skills limits the method’s reach.

Proteins operate on a short timescale — on the order of a millisecond, or even faster

https://go.nature.com/4l7qAEm

Interested in how the heart generates contractile forces to pump blood? Then take a look at our new paper "α- and β-myosin II can be non-uniformly distributed within the cardiac sarcomere". #CellBiology
www.sciencedirect.com/science/arti...

Trump Administration Has Begun a War on Science, Researchers Say Nearly 2,000 scientists urged that Congress restore funding to federal agencies decimated by recent cuts.

Trump Administration Has Begun a War on Science, Researchers Say www.nytimes.com/2025/03/31/s...

Action Intent Links | Bluesky Authors, websites, and apps can use action intent links to implement "Share on Bluesky" buttons, or similar in-app actions. Logged-in users will be directed to the corresponding action view in the Blu...

We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how:

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Xray group getting equiptment training at the beamline from AMB CTO Khoi Nguyen.

Imagine of an extracted mouse pappilary attached to a sample holder.

Extracting a pappilary from the heart.

Group picture with some back goods.

Working hard this weekend at the P03 beamline, PetraIII synchrotron, DESY, Hamburg. Really amazing multi-national team uncovering the secrets of the heart! @droch.bsky.social @edgarnollet.bsky.social @ambiotech.us

I am trying to gauge how much interest is given to muscle wasting in critical illness within the scientific community? This is a very heterogenous condition and would be keen on join forces to further understand it!!!

Special Issue: Physiology of ageing skeletal muscle and the protective effects of exercise: The Journal of Physiology: Vol 603, No 1 <em>The Journal of Physiology</em> publishes research in all areas of physiology and pathophysiology that illustrates new physiological principles or mechanisms.

A really nice special issue in @jphysiol.bsky.social by Dr. Chris Sundberg “Physiology of ageing skeletal muscle and the protective effects of exercise” feat. some work by our lab and many others! Check it out @myoblue.bsky.social physoc.onlinelibrary.wiley.com/toc/14697793...

Excited to be part of a consortium application to the European Rare Disease Research Alliance (ERDERA), lead by Coen Ottenheijm (NL). Among the group, I point out @droch.bsky.social, as we seem to be finding ourselves more and more on the same applications. Our methods really pair well together!

Hearts of hibernating bears use less energy Forskere har identificeret, hvad der helt præcist sker i hjertet hos bjørne, når de går i hi. Opdagelserne kan lede til udvikling af bedre hjertemedicin til patienter med hjertesvigt, siger en...

Good overview of our recent paper: Hearts of hibernating bears use less energy

Nobel laureate: Basic science research is critical for medical progress Victor Ambros, PhD, co-winner of the 2024 prize in medicine, says public support and scientific fellowship fueled discovery of an RNA that regulates genes.

In this Q&A with #NobelPrize recipient Victor R. Ambros, PhD, writer Patrick Boyle comments, “While the science behind the discovery of #microRNA is remarkable, also remarkable is what the discovery illustrates about the importance of basic science research.” direc.to/mEkL @aamctoday.bsky.social