Once again a great collaboration with @ibmm-balard.bsky.social @map-proteomique.bsky.social and other !!!

Honored to award the title of Dr. honoris causa of the University of Toulouse to Dr. Manjula Reddy (CCMB, Hyderabad).
A world-renowned microbiologist, Dr. Reddy has made major contributions to our understanding of bacterial cell division. 🇫🇷🇮🇳

BREAKTHROUGH! Scientists discover Llama antibodies that can fight COVID and its future variants Scientists have unearthed a rare class of ultra-potent antibodies derived from llamas that can neutralize a vast array of coronaviruses—including SARS-CoV-1 and multiple forms of SARS-CoV-2, both old ...

newsable.asianetnews.com/internationa...

Mapping of Mycobacterial Enzymes Involved in Triacylglycerol Accumulation as Intrabacterial Lipid Inclusions Using Activity-Based Multitarget Inhibitor Probes Lipids play a critical role in the physiology, life cycle, and pathogenicity of mycobacteria. They largely participate in host–pathogen interactions and fulfill important functions ranging from cell w...

It is my real pleasure to share our ASAP article published in ACS Infect Dis.
Another great collaboration with @pierresantucci.bsky.social @canaanlab.bsky.social
@lkremer1.bsky.social
@ibmm-balard.bsky.social
@map-proteomique.bsky.social
and more...
Enjoy 😊

pubs.acs.org/doi/10.1021/...

We're always delighted to work together on these exciting projects @jefcavalier.bsky.social @canaanlab.bsky.social

⚠️ Breaking News ⚠️
Another great collaborative work with Victoria Magrioti,
@canaanlab.bsky.social @map-proteomique.bsky.social
now just published in @rscmedchem.rsc.org

pubs.rsc.org/en/content/a...

A new story on antimicrobial peptides published with great collaborators !!

Two ERC-funded postdoc positions available in the team - one here and second to follow - please repost! jobs.ncl.ac.uk/job/Newcastl...

And here jobs.ncl.ac.uk/job/Newcastl...

Great job!! Congratulations @pierresantucci.bsky.social from LISM Lab and @canaanlab.bsky.social

Great job !!👏👏👏👏to all authors !

Great job!! Congratulations @pierresantucci.bsky.social from LISM Lab and @canaanlab.bsky.social

A proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria | mBio This study sheds light into the complex process of intracellular lipid accumulation and storage in the survival and persistence of pathogenic mycobacteria, which is of clinical relevance. By identifying the proteins involved in the formation of ...

Happy to share our last paper published in mBio. A new APEX story !! journals.asm.org/doi/10.1128/...

Nice work congratulations Alexandre and co authors 👏👏👏

You are perfectly right !!! Authors please do not use this nomenclature anymore !!!!

Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus - Journal of Biomedical Science Background Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections, particularly in individuals with underlying conditions, such as cystic fibrosis or chronic obstructive p...

Happy that @map-proteomique.bsky.social has participated oh this nice story from @canaanlab.bsky.social in collaboration with @lkremer1.bsky.social @pierresantucci.bsky.social @jefcavalier.bsky.social link.springer.com/article/10.1...

FEBS Press Salicylic acid (SA), its two iodinated analogues 5ISA and 3,5diISA, as well as the anti-inflammatory drug aspirin (ASP), are anti-TB drugs that disrupt the intrabacterial pH homeostasis of Mycobacter...

After a BioRxiv preprint, here is the final published version of our article dealing with the ph-driven mode of action of salicylic acid derivatives
@pierresantucci.bsky.social
@canaanlab.bsky.social
and more

febs.onlinelibrary.wiley.com/doi/10.1002/...

Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus - Journal of Biomedical Science Background Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections, particularly in individuals with underlying conditions, such as cystic fibrosis or chronic obstructive p...

Our last article dealing with Cyclipostin & Cyclophostins compounds to counteract macrolide-induced resistance in Mabscessus is out!
Great collaborative work @lkremer1.bsky.social @canaanlab.bsky.social @pierresantucci.bsky.social @camoinluc.bsky.social

jbiomedsci.biomedcentral.com/articles/10....

Happy to share scientific @pierresantucci.bsky.social paper useful to facilitate screening of CrispRi mutants @Febs letters
Doi: 10.1002/1873-3468.15071

Genetically diverse Mycobacterium tuberculosis isolates manipulate inflammasome activation and IL-1β secretion independently of macrophage metabolic rewiring The glycolytic pathway is required for maximum IL-1β production by macrophages infected with live distinct M. tuberculosis isolates, but mitochondria metab

Interesting paper showing different M tuberculosis strains induce varying levels of IL-1beta via inflammasome activation.

Curious to understand how that relates to infection clearance & disease severity.

#TBSky #IDSky #ImmunoSky #Immunometabolism