Spatial dynamics of brain development and neuroinflammation - Nature A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.

Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com

www.nature.com/articles/s41...

📣 We're hiring a postdoc to join our growing team @exeter.ac.uk!
Love developmental neurobiology, RNA regulation & cortical circuits? This might be for you 🧑‍🔬
Apply here 👉 tinyurl.com/2d659uj7
Please share!

a man in a suit is holding a jacket and a cigarette . ALT: a man in a suit is holding a jacket and a cigarette .

Interesting how companies and the financial world is racing to spend mindboggling amounts of money to build the infrastructure to train computers. But we are leaving the infrastructure to train and educate humans crumbling. The question is who will train who?

Photo: Cecilia Odlind

The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body 🧪 www.nobelprize.org/prizes/medic...

Choose Europe for Science needs also strong postdoc fellowship funding.

University Researcher in Bioimaging / Universitetsforskare med inriktning bioimaging, 1.11.2025-31.12.2030

Come and work with us 5-year position available for a University Researcher in Bioimaging 1.11.2025-31.12.2030

abo.rekrytointi.com/paikat/index...

Do inhibitory interneurons encode information or just keep the rhythm? Inhibitory interneurons may help encode the brain’s internal representation of space

There's a very cool Buzsaki #neuroskyence paper out in Science this week, looking at hippocampal spatial information encoding by multiple interneuron subtypes in parallel. The brilliant @agonru.bsky.social and I wrote a wee perspective to go alongside it: www.science.org/doi/10.1126/...

Novel environment exposure drives temporally defined and region-specific chromatin accessibility and gene expression changes in the hippocampus - Nature Communications Hippocampal neurons adapt to experience through changes in gene expression and chromatin accessibility. Here, authors show that novel environment exposure induces region- and cell-type specific transc...

Extremely excited to share the outcome of a fantastic collaboration with @erinduffyphd.bsky.social revealing how experiences reshape hippocamapl chromatin and gene expression.
Check out our searchable gene database and look up your favorite gene 🧬

www.nature.com/articles/s41...

Final call: Applications close September 2! KI is recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. All positions: ki.se/en/about-ki/...

Please RP.
We are thrilled to announce that our lab’s first preprint is out!
”Whole-genome single-cell multimodal history tracing to reveal cell identity transition”

We report HisTrac-seq, a multiomic single-cell molecular recording platform.
www.biorxiv.org/content/10.1...

Molecular programs specifying properties and plasticity of parvalbumin interneuron innervation Parvalbumin-positive (PV) interneurons, a class of fast-spiking GABAergic interneurons, govern gain-control and the timing of neuronal signal propagat…

@scheiffelelab.bsky.social and I discussed the unique properties of synapses onto parvalbumin interneurons, the current knowledge & future aspects of the molecular mechanisms regulating these synaptic inputs: www.sciencedirect.com/science/arti...

False positives in study of memory-related gene expression - Nature Nature - False positives in study of memory-related gene expression

www.nature.com/articles/s41...

The engram is still out there, waiting to be rigorously discovered!

Postdoc in Single Cell Genomics, Jens Hjerling-Leffler group, Karolinska Institutet Do you want to contribute to top quality medical research? The position is located within The Division of Molecular Neurobiology in the lab of Professor Jens Hjerling-Leffler at the Department of Medi

Postdoc positions available in my lab @ki.se Sweden - exciting science, fantastic environment and great quality of life. I take mentoring seriously - 7/7 postdocs that left my lab has faculty positions today. Existing datasets and funds to build new ones available. ki.varbi.com/en/what:job/...

Endometriosis Foundation of America commits $10 million to CSHL | Cold Spring Harbor Laboratory From being told that their pain is not real to facing the heartbreak of infertility and even the threat of death, women dealing with endometriosis face incredible, sometimes lifelong journeys that can...

For the 200 million women worldwide with endometriosis—a disease often misunderstood and underdiagnosed—this dedication to scientific discovery is a huge step in the right direction. #Endendo #EndoFound #Endometriosis
www.cshl.edu/endometriosi...

ATLAS: a rationally designed anterograde transsynaptic tracer - Nature Methods ATLAS is a tool for circuit tracing, demonstrated here in rodents. It allows anterograde transsynaptic tracing, starting from genetically defined neurons.

ATLAS, a rationally designed transsynaptic tracer is out today! Plasmids will soon be available on
@addgene.bsky.social
addgene nature.com/articles/s41...

Many thanks to first authors Jackie Rivera and Haoyang Huang, and to collaborators @blsabatini.bsky.social @beherring.bsky.social

1/10 Our latest research, led by @martijnselten.bsky.social, identifies a mechanism through which Parvalbumin (PV) interneurons regulate their activity in the #cortex. This is the story @nature.com
www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu

The SNSF urges against cuts In its statement on "Relief Package 27", the SNSF speaks out against the proposed annual cuts of 10 percent.

❗Serious consequences for the Swiss economy and society – the SNSF urges the abandonment of the proposed cuts to research funding in "Relief Package 27," as they threaten the country's innovative capacity and competitiveness.

➡️

🍁🚨 WE'RE HIRING!🚨🍁 Our baby lab at the University of Toronto is expanding, many many thanks to funding from #CIHR and @hfspo.bsky.social. We are in search of a technician, postdoc, and PhD students! Further details on our website (sawhlab.netlify.app/people/), please share!

Thrilled to share new work from the lab, led by Adam Ramsaran:
authors.elsevier.com/a/1kva73QW8S...

Alert! Postdoc positions available - at least two. Interested in coming to Karolinska and work on adolescent development/schizophrenia? Have a background in neuroscience, functional genomics, computational analysis or spatial transcriptomics? Large data sets available for analysis. Get in touch!

Postdoc opportunity in the heart of Europe! Check out the flyer below.
Join our team on an international project with Anthony Holtmaat exploring synaptic plasticity and specificity in cortical and thalamocortical circuits.

Synaptic architecture of a memory engram in the mouse hippocampus Memory engrams are formed through experience-dependent plasticity of neural circuits, but their detailed architectures remain unresolved. Using three-dimensional electron microscopy, we performed nano...

"How are memories formed and stored in the brain?...Long-term memory acquisition was found to be associated with a selective increase in multisynaptic boutons..". Groundbreaking new study from my friend and colleague Anton Maximov's lab: www.science.org/doi/10.1126/...
Bonus: My son Luca's first pub

📣 Postdoc opportunity !
Our lab is hiring a funded postdoc to explore the development of fear circuits using slice electrophysiology. If you have expertise in this area and are interested about cutting-edge neuroscience, reach out ! 🤗
klinglerlab.org
Please share with your network 🙏

Congratulations to Nesibe Temiz on successfully defending her PhD thesis last week! During her PhD, she explored how the brain's ability to process sensory information changes during development and learning 🧠✨

Apply now for the prestigious and independent #BiozentrumPhDFellowships. Great science. Unique rotation-based selection of research group and other incentives. The summer call is open until May 18, 2025. bit.ly/4caiqqX @biozentrum.unibas.ch @unibasel.ch
#fellowship #PhD #Switzerland #lifesciences

Dynamic regulation of cortical interneuron wiring Inhibitory interneurons play crucial roles in modulating the circuits and activity patterns of the cerebral cortex. In particular, interneurons must a…

Our little update on the latest knowledge on interneuron wiring! www.sciencedirect.com/science/arti...

Celebrating our #WomenInSTEM: Hanna Hörnberg YouTube video by Max Delbrück Center

"My mom will always be a role model for me. She always instilled this sense into me that everything is possible," says @hannahornberg.bsky.social, head of the "Molecular and Cellular Basis of Behavior" lab at #mdcBerlin.

Tell us who has inspired you! 👇 #mdcDiversity #WomenInSTEM #WomenInScience

Novel environment exposure drives temporally defined and region-specific chromatin accessibility and gene expression changes in the hippocampus Curiosity-driven interactions with novel cues in our environment represent a common behavioral trait across the animal kingdom. Exposure to a novel environment (NE) reshapes the brain by promoting str...

Super-interesting new preprint from the Greenberg lab on a systematic analysis of plasticity-associated gene regulation!

I am looking for electrophysiologists for couple of very exciting projects. Recent PhD graduates (defended within 2 years) is preferred, but open to other possibilities too. The lab is funded by ERC, SSMF, Brain Foundation, StratNeuro and others. Find me at KI. DM or email.

New insights into blood vessel formation Researchers of the Markus Affolter lab at the Biozentrum have uncovered new mechanisms in blood vessel formation.

Researchers of the Markus Affolter lab @biozentrum.bsky.social have uncovered new mechanisms in #bloodvessel formation, showing the interaction of cells and the critical role of dynamic forces. Interesting also for treatment of #vasculardiseases. @unibas.ch #angiogenesis ow.ly/gkzE50Usmbh