Finally out: We used CRISPRa/i to show that virtually ANY genomic site can become regulatory for cardiac genes—even without accessibility or active marks. TF recruitment remodeled chromatin & changed expression up to 70 kb away, crossing insulating loci.
pubmed.ncbi.nlm.nih.gov/41536997/
Found in translation: Using single-molecule imaging, we show that ERK signaling controls where protein translation happens during hypertrophic stimulation in #cardiomyocytes —revealing a dynamic, localized response. #Biorxivpreprint #cardiosky
Read: www.biorxiv.org/content/10.1...
Imagine if we cited preprints by default, even after journal publication. Time to burst the impact factor bubble?
“I told her she could and would lead a continue to lead a full life” is simply not true for many patients with heart failure. Lying to your patients is unethical
In music, even famous artists cover songs, and some bands play almost exclusively covers. What if science had the same? “In this manuscript, we’re covering the classic paper from ‘04.”
Still waiting for a study that doesn’t end with “more research is needed.” Just one that says, “That’s it. We’ve figured it out.”
While assessing quality can be challenging, evaluating quantity is much simpler. As a result, authors, editors, and reviewers often focus on what can be measured
Helvetica or similar sans
You’re in for a lot of surprises
Many academics point to bioRxiv as “the one thing improving science publishing”.
If so, the one thing you all can do is persuade colleagues to submit and make this a norm. 1/2
Should we create an academic cryptocurrency? Mining would happen through peer reviews and committee meetings, eventually convertible to the ultimate hard currency: pizza
Image of the linked paper
🚨📢Paper alert! Real progress on identifying why residual force enhancement occurs in skeletal muscle! This was a study I dreamed about since grad school. Please share! 🔬💪🧪
www.pnas.org/doi/10.1073/...
Some of the big news we report: "...suggesting that upon activation, [I-band] titin stiffness increased ~2.2 to 3.1 times compared to the passive state"
#MyoBlue
This is when editorial decisions are useful. An editor can reject a paper outright. Obviously not always a good thing, but sometimes it’s useful
The Church of the FSM Holiday e-Card Machine is live again with new designs. Please send festive greetings to your friends and family.
app.spaghettimonster.org/card/create
I like to celebrate the small victories in science. For example, today I fixed the lab vacuum trap
Idea: develop a new method and use it to uncover lots of cool new biology
Reality: develop a new method and use it on one well known and well characterized piece of biology
Is the difference in the impact factors between journal statistically significant? Journal should specify the statistical test used, n, and exact p value when referring to their JIF
We are happy to report that our journals and community sites now have Bluesky accounts. Follow them at:
@dev-journal.bsky.social
@jcellsci.bsky.social
@jexpbiol.bsky.social
@dmmjournal.bsky.social
@biologyopen.bsky.social
@the-node.bsky.social
@prelights.bsky.social
@focalplane.bsky.social
Organizing academics is like herding cats—both are much easier with pizza involved
Maybe editors should just invite reviewer # 1,2, and 4?
Like paring of food and wine, I am in favor of pairing music to lab experiments. In my experience Neil Young works great with RNA extraction.
I wish there was at least one student in class that looked at me that intently
I see remarks in grants review about applicants productivity. How is that measured? I suggest printing out and weighing the papers the applicant wrote, multiply be impact of journal and divide by time. Unit of 1 gr•impact/ year or 1 Clarivate
Like the game where we answer questions without using any of the four forbidden words: yes, no, black or white, can we review a paper without using: mechanism, in vivo , and rigor?
I have risked my life for my county, I have treated injured under ‘freedom fighters’ fire , I have protested for 40 consecutive weeks against my government. What about you, condescending racist?
As a racist you condescend over the Palestinians. You do not thinks of them as man capable of action. Babies? Americans rebelled against tyranny, many other people did. Why can’t the Palestinians? Who promised easy? Life may easy for you, not so for most others
Ever heard of the Arab spring? People in Libya dethroned Gaddfi. There are many examples. People have power. They need the will to do exercise it. You either support Hamams or you fight against it.
Maybe this is something they should have considered before they launched thousands of missile into towns and butchered babies? Destroying Hamas is the best thing that can be done for the Palestinians
Some died waiting? How did they die? Fell off a cliff? You missed burnin families in their houses, slaughter, rape and beheading in your timeline