Given these scanner differences, harmonization is essential! In unharmonized data, acquisition batch explained up to 70% of microstructural variance. We used cutting-edge longitudinal nonlinear harmonization, which eliminated these effects while preserving developmental effects.

Huge thanks to the incredible team of 50 co-authors who made this possible! Special thanks to our lab replicator + dMRI guru @cieslakmatt.bsky.social, the UMN team led by @drdamienfair.bsky.social, and my incredibly supportive postdoc advisor @ted-satterthwaite.bsky.social! Preprint: bit.ly/3QMLG0K

Community Review: BEP032 - Microelectrode Electrophysiology · bids-standard bids-specification · Discussion #2406 We are pleased to announce the community review period for BIDS Extension Proposal (BEP) 032! BEP032 extends the BIDS standard to describe microelectrode electrophysiology data. The draft specifica...

We are pleased to announce that BIDS Extension Proposal 32 - Microelectrode Electrophysiology is open for community review!

github.com/bids-standar...

The review period is open from April 20 - May 1.

#bids #neuroimaging #electrophysiology

Community Review: BEP028 - Provenance · bids-standard bids-specification · Discussion #2405 We are pleased to announce the community review period for BIDS Extension Proposal (BEP) 028! BEP028 extends the BIDS standard to describe the provenance of BIDS datasets. It introduces new organiz...

We are pleased to announce that BIDS Extension Proposal 28 - Provenance is open for community review!

github.com/bids-standar...

The review period is open from April 20 - May 1.

#bids #neuroimaging #provenance

Huzzah for @stevenmeisler.com, whose preprint on our new fully-processed ABCD dMRI data resource is now out. The super-clear results from this monumental effort will undoubtably change the way we approach studies of white matter development going forward.

Diffusion MRI (dMRI) is a powerful tool to study white matter maturation. In our new preprint, we process and distribute a new resource of >24,000 ABCD dMRI scans using open source tools! We then evaluate how methods shape inferences about development.

🔗 www.biorxiv.org/content/10.6...

✨Excited to share that our new preprint, "Mapping developmental patterns of intrinsic timescale", is now available on bioRxiv!!
📚 doi.org/10.64898/202...

The PMADS Project: A Longitudinal Multimodal Cohort Study to Understand Risk for Perinatal Mood and Anxiety Disorders www.biorxiv.org/content/10.64898/2026.04...

a man is standing in a kitchen with his hands on his chest and asking for help . Alt: Tom Cruise is standing in a kitchen with his hands on his chest and asking for help, saying "Help me, Help you"

A systematic meta-analysis is hard work—and curation is often the hardest part. Y'all know this better than anyone, and we want to make it easier.

What’s one specific piece of information you consistently had to find or extract from every paper?
Tell us about it: tally.so/r/QKVbQG

#neuroscience

Refreshing this -- we are still reviewing applications for a spring/summer 2026 start date!!!

Depression as a disease of white matter network disruption: Learning from Multiple Sclerosis Depression is a common and debilitating psychiatric disorder that is associated with substantial morbidity and mortality. For nearly 40 years, scientists have attempted to localize depression in the b...

Excited to share that our new review, "Depression as a disease of white matter network disruption: Learning from Multiple Sclerosis," is out now in Biological Psychiatry! We propose MS as a powerful model for studying how white matter network changes contribute to depression.

The Transmitter’s Rising Stars of Neuroscience 2025 We recognize the outstanding achievements of 25 neuroscientists who stand to shape the field for years to come.

BEYOND delighted to see two brilliant #PennLINC alumni -- @valeriejsydnor.bsky.social + @lindenmp.bsky.social -- named by The Transmitter as "Rising Stars of Neuroscience 2025". Super well deserved -- CONGRATS!!!

www.thetransmitter.org/early-career...

🧠I am excited to announce that our manuscript introducing a new data resource – PennLEAD (Penn Longitudinal Executive functioning in Adolescent Development) – is now available on bioRxiv. Below are some details highlighting our data resource🧵funded by NIMH R01MH113550
www.biorxiv.org/content/10.1...

An Open, Fully-processed, Longitudinal Data Resource to Study Brain Development and Transdiagnostic Executive Function www.biorxiv.org/content/10.1101/2025.11....

Happy to share our review "Investigating hierarchical critical periods in human neurodevelopment” in @npp-journal.bsky.social! We examine neurobiological, environmental & behavioral evidence for human critical periods in sensory and association cortex +discuss new research directions rdcu.be/eMkVU 🧵

Truly heroic work by the stellar @cieslakmatt.bsky.social + the HBCD dMRI working group team. Refactored QSIPrep + QSIRecon is the result of nearly 3y of concerted development + testing. It will be a total workhorse for HBCD -- and almost any other dMRI scan. Check it out for your data!!!

GitHub - PennLINC/qsiprep: Preprocessing of diffusion MRI Preprocessing of diffusion MRI. Contribute to PennLINC/qsiprep development by creating an account on GitHub.

QSIPrep and QSIRecon are usable beyond HBCD. Code, containers, and documentation are openly available. github.com/PennLINC/qsi..., github.com/PennLINC/qsi...

A flow diagram describes the preprocessing workflow and additions specifically added for HBCD. Critical additions are Gibbs Unringing, a second stage of distortion correction, MNI Infant support and Synthstrip and Synthseg.

We made numerous updates to the QSIPrep and QSIRecon software packages to better perform on HBCD’s infant/pediatric diffusion MRI. New preprocessing includes partial-Fourier Gibbs unringing, MP-PCA, 2-stage susceptibility distortion correction, SynthStrip/Synthseg and MNIInfant atlases.

Diffusion MRI Processing in the HEALthy Brain and Child Development Study: Innovations and Applications The landmark ongoing HEALthy Brain and Cognitive Development (HBCD) study will longitudinally chart brain development in a large sample (projected n=7,200) of infants through age 10 years with multimo...

After years of development and testing, we are happy to present our work in "Diffusion MRI Processing in the HEALthy Brain and Child Development Study: Innovations and Applications"! www.biorxiv.org/content/10.1.... A thread:

Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function Nature Neuroscience - Padawer-Curry et al. show that the hallucinogenic 5-HT2A receptor agonist DOI alters neurovascular coupling in mice, with implications for the interpretation of human fMRI...

🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging.
👇🧵

nature.com/articles/s41...
#Neuroscience #Psychedelics #BrainImaging

Community Review: BEP020 - Eye Tracking · bids-standard bids-specification · Discussion #2218 We are pleased to announce the community review period for BIDS Extension Proposal (BEP) 020! BEP020 extends the BIDS standard to formally specify eye-tracking recordings, which has previously been...

We are pleased to announce that BIDS Extension Proposal 20 - Eye Tracking is open for community review!

github.com/bids-standar...

The review period is open from September 29 - October 10.
#bids #neuroimaging #eyetracking

Community Review: BEP042 - Electromyography (EMG) · bids-standard bids-specification · Discussion #2219 We are pleased to announce the community review period for BIDS Extension Proposal (BEP) 042! BEP042 extends the BIDS standard to include electromyography recordings. The draft specification may be...

We are pleased to announce that BIDS Extension Proposal 42 - Electromyogrpahy is open for community review!

github.com/bids-standar...

The review period is open from September 29 - October 10.
#bids #neuroimaging #electromyography #emg

How does the human brain coordinate hierarchical cortical development? Our work in Nature Neuroscience identifies a role for thalamocortical structural connectivity in the expression of hierarchical periods of cortical plasticity & environmental receptivity in youth 🧵 www.nature.com/articles/s41...

Check out this stellar work from the one-and-only @valeriejsydnor.bsky.social w/ team at @pennlinc.bsky.social + (many!) friends -- providing new evidence that thalamo-cortical connectivity coordinates the hierarchical progression of cortical plasticity in development. Out in @natneuro.nature.com.

Amelie Rauland (all star via IRTG student w/ @sbe.bsky.social ) will be presenting "Benchmarking Reconstruction Methods for Bundle Segmentation in Single-Shell dMRI" on Friday and Saturday, Poster #1283

@bencephalon.bsky.social from @aarona-b.bsky.social 's lab will be presenting "Integrating clinical and research imaging to uncover neuroanatomic deviations in 22q11.2 deletions" Wed, June 25, 13:15 -15:15 & Thurs, June 26, 13:45 -15:45; Poster #697

@kevin-y-sun.bsky.social‬ will be presenting his work on "Copy Number Variant Risk Scores Are Associated with Personalized Functional Brain Network Topography" Wed, June 25, 13:15 - 15:15 & Thus, June 26, 13:45 - 15:45

@audreycluo.bsky.social will be presenting her fab work on "Two Axes of White Matter Development" on Wed, June 25, 13:15 -15:15 & Thurs, June 26, 13:45 -15:45; Poster #1010.

Want more RBC? Come chat with me at the RBC poster Friday, Jun 27 & Saturday June 28: 13:45 – 15:45 PM; Poster #1816.

I will provide a (poor) substitute for @goliashf.bsky.social and discuss Reproducible Brain Charts as part of the "OSR Table Talk on Recommended Practices in Open Science" Friday, June 27, from 8–9 AM in Exhibition Hall 1