If you are interested in neural manifolds, dimensionality, brain states, and/or top-down modulation you are gonna like this one! 🧠🙈💫🧪

"Neural manifolds in V1 change with top-down signals from V4 targeting the foveal region" doi.org/10.1016/j.ce...

Also enjoy this animation :) #SciArt #neuroskyence

The unexpected sight: improvement of visual function following intracortical microstimulation of the human occipital cortex Alfaro et al. report the case of a blind individual who participated in a clinical trial involving intracortical microstimulation of the visual cortex. Fol

A blind person recovered low vision within a few days of being implanted with a Utah array and receiving electrical stimulation in the visual cortex.

An unexpected and exciting discovery by @umh.es researchers 👀🧠

doi.org/10.1093/brai...

🎊 In a year marked by sustained pressure on biomedical research and increasing uncertainty across academia, I want to pause and recognize the Kozai Lab and its community. Despite unexpected changes… ... 🎊 In a year marked by sustained pressure on biomedical research and increasing uncertainty across academia, I want to pause and recognize the Kozai Lab and its community. Despite unexpected changes a...

www.linkedin.com/posts/tkozai...

#NEUmap: Large-scale mapping of artificial perceptions for neuroprostheses using spontaneous neuronal activity in macaque and human visual cortex www.brainstimjrnl.com/article/S193... by @lozaneuro.bsky.social et al.; #BCI #NeuroTech #blindness

As #neurotechnology scales toward high-resolution implantable devices, new challenges emerge: how will users calibrate visual implants with thousands of channels?

Learn how by reading our paper, co-first-authored with Dr. Xing Chen, now published at Brain Stimulation!

tinyurl.com/Large-scale-...

🧠 From NIH-funded discovery → game-changing brain implants → NEW science that was impossible before.
This loop = cures, jobs & American tech leadership 🇺🇸

Join me MONDAY 12/8, 1pm ET:

"Next-Gen Neural Interfaces → Next Scientific Revolution”

🚀 #NeuroTech #BCI #NIH #BrainTech #TaxpayerWin

Honored to be appointed the Ernest E. Roth Professor at Pitt. Grateful for the trainees, collaborators, and colleagues advancing neural engineering and glial biology. Thank you to the Dean for supporting our UP NExT vision, engineering fundamental neuroscience discovery to improve lives.

Presenting “Human in the loop optimisation for efficient intracortical microstimulation temporal patterns in visual cortex” again this afternoon at #SfN!!

Come discuss!

An amazing collaboration between the Biomedical Neuroengineering group at UMH and @bionicvisionlab.org

Presenting “Human in the loop optimisation for efficient intracortical microstimulation temporal patterns in visual cortex” again this afternoon at #SfN!!

Come discuss!

An amazing collaboration between the Biomedical Neuroengineering group at UMH and @bionicvisionlab.org

Schematic labeled human-in-the-loop optimization (HILO). It shows two stimuli on the left: pulse trains with varying stimulus amplitude over time. A participant has to choose which stimulus appears brighter. This feedback is used to inform a Gaussian process model that chooses the next stimulus pair, with the goal of finding the stimulus with the lowest overall charge to elicit perception

Our final poster at #SfN2025 explores human-in-the-loop optimization for intracortical microstimulation, presented by @lozaneuro.bsky.social, in collaboration with @umh.es:

PSTR450.20
Nov 19 at 1:00 PM
www.abstractsonline.com/pp8/#!/21171...

#SfN25 #VisionScience #NeuroTechnology

I will be presenting the poster “Human-in-the-loop optimisation for efficient intracortical microstimulation temporal patterns in visual cortex” at the Early Career Poster Session #SfN as a TPDA awardee!

Nov. 15, 2025
18:45–20:45 (PT)
Poster: G5
SDCC Halls C–H

Come discuss!

🧠 🤖 #SfN25 - these amazing trainees are pioneering multifunctional brain-computer interfaces and deep inference of multi-area dynamics!

Brain-computer interface for a patient with quadriplegia A team at the Technical University of Munich’s TUM University Hospital has implanted a brain-computer interface in a patient paralyzed from the neck down.

A big push for #BCI and #neurotechnology in Europe! We implanted our second microelectrode array #BCI @tum.de. Huge thanks to our pioneer and to fantastic colleagues in #Neurosurgery and #Robotics #Machine #Intelligence 🧠🦾🧪 #neuroskyence @neuroengineering.bsky.social
www.tum.de/en/news-and-...

Super exciting opportunity!!

Long time in the making: our preprint of survey study on the diversity with how people seem to experience #mentalimagery. Suggests #aphantasia should be redefined as absence of depictive thought, not merely "not seeing". Some more take home msg:
#psychskysci #neuroscience

doi.org/10.1101/2025...

For a long time, some have daydreamed about whether neural networks can learn to effectively synthesize stimulation patterns to write information into the brain.

Introducing 𝐃𝐞𝐞𝐩 𝐋𝐞𝐚𝐫𝐧𝐢𝐧𝐠-𝐁𝐚𝐬𝐞𝐝 𝐂𝐨𝐧𝐭𝐫𝐨𝐥 𝐨𝐟 𝐄𝐥𝐞𝐜𝐭𝐫𝐢𝐜𝐚𝐥𝐥𝐲 𝐄𝐯𝐨𝐤𝐞𝐝 𝐀𝐜𝐭𝐢𝐯𝐢𝐭𝐲 𝐢𝐧 𝐇𝐮𝐦𝐚𝐧 𝐕𝐢𝐬𝐮𝐚𝐥 𝐂𝐨𝐫𝐭𝐞𝐱
www.biorxiv.org/content/10.1...

Had a great first day at the Bernstein workshop on control theory uses in neuroscience! I presented some of our work on control theory behavior assays for movement, and approaches to designing BCIs.

Undecided which workshop to attend at #BernsteinConference ?

We put together a stellar lineup for a satellite workshop on the effects of top-down signals on neuronal dynamics! 🧠✨📣

Join us tomorrow in room 0.101 !

bernstein-network.de/bernstein-co...

With @ackurth.bsky.social

An extensive dataset of spiking activity to reveal the syntax of the ventral stream Papale et al. present an extensive public dataset of spiking activity of V1, V4, and IT neurons in monkeys viewing thousands of natural scenes. The THINGS ventral stream spiking dataset (TVSD) can pro...

Now also 1024 electrodes in V1 + V4 + IT

www.cell.com/neuron/abstr...

Asymmetric projection of introspection reveals a behavioural and neural mechanism for interindividual social coordination Nature Communications - When we collaborate with others to tackle novel problems, we anticipate how they will perform their part effectively. Miyamoto et al find that metacognitive projection...

Our new paper on anterior prefrontal role of 'social metacognition' (projection of one's own introspection to imagine others' thought) is just out at Nature Communications rdcu.be/d6Tcg

Every time I get a new subscriber on substack I get an email, and it's so nice to see familiar names from the present and the past. There's a warm fuzzy feeling to know that people appreciate that I periodically clog their inbox with my 3000+ word ramblings

Mapping pipeline.

#NEUmap: Large-scale RF mapping without visual input for neuroprostheses in macaque and human visual cortex www.medrxiv.org/content/10.1... by @lozaneuro.bsky.social @aitormg.bsky.social et al.; "a rapid, largely automated method for phosphene mapping"; #BCI #NeuroTech #neuroscience

The energy savings of fish that swim together.
elifesciences.org/articles/96129

An integrative data-driven model simulating C. elegans brain, body and environment interactions - Nature Computational Science BAAIWorm is an integrative data-driven model of C. elegans that simulates interactions between the brain, body and environment. The biophysically detailed neuronal model is capable of replicating the ...

Great set of activities around C. elegans modeling. nature.com/articles/s43... see summary: nature.com/articles/s43...

That's a wrap! I hope you enjoyed some of my very subjective choice of comp neuro papers!

Happy holidays to y'all! 🥳🎄✨️

More holiday reading! We argue that BCIs should be classified based on their intended application, and that this language is best for the public, regulators, policy makers, etc.

1/ In March 2023, I received a lumbar puncture. This was key to receiving my chronic inflammatory demyelinating polyneuropathy #cidp diagnosis. This 🧵 is on my experience with identifying and treating #autoimmunedisease. I'll also be sharing some 🧵s I posted previously on the Other Place.

DAY 15: Advent of Comp Neuro 🎄🤖🧠🧪

Heterogeneity of neural properties can improve some computational functions, but homogeneity also has its advantages! It's complicated 😅

“Neural heterogeneity controls computations in spiking neural networks”
@rgast.bsky.social et al
www.pnas.org/doi/epub/10....

computational/theoretical neuroscientists, how important it is to you that you can be in the same building w/ experimentalists who are interested in conducting new studies to directly test your ideas / predictions?

or u think outside collaborators + analyzing existing datasets are just as well?