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Posts by Bill Cresko

Coalescence and translation: A language model for population genetics | PNAS Probabilistic models such as the sequentially Markovian coalescent have long provided a powerful framework for population genetic inference, enabli...

Whoaโ€”machine learning strikes again (in a good way)

www.pnas.org/doi/10.1073/...

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Duck

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A picture of Mt Adams

A picture of Mt Adams

A little R&R at a great treehouse (truly a treehouse) in White Salmon for a couple of days. Coffee and a beautiful view of Mt. Adams this morning.

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And we did harvest Genomes drives. This is what over 400TB in drives looks like in my office.

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May your cycles reverberate through the universe for ever.

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In 2012 I received a $50k grant from the Murdock Foundation to build our computer cluster Genome that @jcatchen.bsky.social helped me build. After years of faithful service, dozens of papers and countless trainees using it we flipped the main power off to it for the last time.

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Stephen Atkinson- very well done and I appreciate the microbiome shout out too!

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Stickleback painting.

Stickleback painting.

Visit to OSU for a grad student defense and ran into a familiar face in the stairwell of Nash Hall!

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Spaceflight Started 100 Years Ago in a Massachusetts Cabbage Patch

Spaceflight Started 100 Years Ago in a Massachusetts Cabbage Patch www.nytimes.com/2026/03/16/s...

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snputils (snputils.org): A High-Performance Python Library for Genetic Variation and Population Structure www.biorxiv.org/content/10.6... ๐Ÿงฌ๐Ÿ’ป๐Ÿงช github.com/AI-sandbox/s...

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Oregon Battle of the Books (OBOB). Hundreds of kids ready to match their reading chops. So cool.

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Nice talk in the IE2 seminar series at UO about carbon in soils by @katerinageorgiou.bsky.social from Oregon State.

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Evolution 2026 meeting logo. Clilp art of a globe and laptop showing a virtual presentation. Text: Society for the Study of Evolution Global Meeting Participation.

Evolution 2026 meeting logo. Clilp art of a globe and laptop showing a virtual presentation. Text: Society for the Study of Evolution Global Meeting Participation.

SSE is pleased to offer free virtual #Evol2026 registration to all SSE members residing in 152 countries and territories around the world including India, Brazil, Mexico, and Colombia. Request your free registration code today! www.evolutionsociety.org/index.php?mo...

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Nominations are open to the annual ๐— ๐—ผ๐—น๐—ฒ๐—ฐ๐˜‚๐—น๐—ฎ๐—ฟ ๐—˜๐—ฐ๐—ผ๐—น๐—ผ๐—ด๐˜† ๐—ฃ๐—ฟ๐—ถ๐˜‡๐—ฒ!
The award recognizes the work of outstanding scientists for their contribution to the field of molecular ecology. Nominations are due on ๐Ÿฎ๐Ÿฐ ๐—”๐—ฝ๐—ฟ๐—ถ๐—น ๐Ÿฎ๐Ÿฌ๐Ÿฎ๐Ÿฒ.
Read more: onlinelibrary.wiley.com/page/journal...

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Fred Hutchinson Cancer Center Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.

My awesome colleague, @yarimura.bsky.social, is recruiting a postdoc to start at the end of 2026 or early 2027! His lab uses cryo-EM to uncover structural basis of key chromatin events using native complexes isolated from human cells or Xenopus egg extracts!

careers-fhcrc.icims.com/jobs/30706/p...

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I was sad to learn that my postdoctoral mentor, David Botstein, died yesterday. I started with David as a postdoc in 1998, and he had a profound effect on both my life and scientific career. He was a giant in the field of genetics, making seminal contributions in both yeast and human genetics. 1/

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We are all Claude.

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Shakshuka.

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An image of a large protest in Eugene.

An image of a large protest in Eugene.

Several thousand patriots speaking up and protesting peacefully in downtown Eugene.

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๐Ÿ“ก๐Ÿงต Excited to release an updated version of our preprint: Zebrahub-Multiome: Uncovering Gene Regulatory Network Dynamics During Zebrafish Embryogenesis
๐Ÿงช๐Ÿงฌ๐Ÿ–ฅ๏ธ๐Ÿ 

doi.org/10.1101/2024...
A tour-de-force by @yangjoonkim with an unexpected discovery!

2 months ago 51 17 2 2
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Homepage - 2026 Population, Evolutionary, and Quantitative Genetics Conference Visit our website to learn more.

PEQG! My favorite conference ever*. Single session, fantastic talks, great discussions. Only once every 2 years. And in the best conference location too! Abstract deadline coming up Feb 5!

*Disclosure: I am required to say it's the best conference because it is and I told my mom I wouldn't lie.

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Well put grasshopper.

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Yum

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I love when the prep is all done for dinner and everything is laid out and ready to go. Oregon sole with olives and rosemary and garlic and wild rice.

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Cool bay pipefish exhibit at the Oregon Coast Aquarium in Newport Oregon.

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The U.S. Is Funding Fewer Grants in Every Area of Science and Medicine (Gift Article) A quiet policy change means the government is making fewer bets on long-term science.

๐ŸŽ gift link to #science funding article about cuts to research grants ๐Ÿงช๐Ÿงฌ๐Ÿ”ฌ๐Ÿ”ญ๐Ÿฅผ

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โ€œFundamentally, the premise of the document is inconsistent with our core belief that scientific funding should be based on scientific merit alone,โ€ Dr. Kornbluth wrote.

Follow the lead the rest of you.

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โ€˜A whole body of health-equity research is being disappearedโ€™ โ€” why I resigned from the NIH As federal support vanishes for research addressing the root causes of health disparities in the United States, we are left with a dangerous void and an urgent need to rethink science funding.

Excellent piece from a former NIH colleague and #BethesdaDeclaration co-signer.

She highlights the ongoing censorship at NIH and calls for the following three actions:

www.nature.com/articles/d41...

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Mmm- I asked in my browser what one dollar of Apple stock purchased in 1999 would be worth today. The AI answer - โ€œ
If you had $1 in Apple stock bought in 1999, it would be worth approximately $1.04 trillion today based on the average annual growth rate of Apple's stockโ€ real answer ~ $160

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a man in a suit and tie is dancing . ALT: a man in a suit and tie is dancing .

Sorry, I meant he starts 11th grade in the Fall!

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