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Posts by SFB1361

Publication alert!! 📃

Congratulations to the Hopfner lab (@hopfnerlab.bsky.social) on their new publication:

"Recognition and remodelling of nucleosomes and hexasomes by the human INO80 complex"

🔎Find out more here: doi.org/10.1093/nar/...

3 weeks ago 1 0 0 0
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RNF25 confers mRNA damage tolerance by curbing activation of the integrated stress response Excessive RNA damage activates cellular stress responses, triggering cell death. However, pathways that negatively regulate RNA damage responses are l…

New publication!📃

Happy to share the new joint publication by our #SFB1361 PI's Julian Stingele (@jstingele.bsky.social) and Petra Beli,

covering how RNF25 confers mRNA damage tolerance by curbing activation of the integrated stress response.

Read more here: www.sciencedirect.com/science/arti...

3 weeks ago 1 0 0 0
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IMB & SFB 1361 Conference 2026 taking place right now 🧬
#ISC26DNArepair

1 month ago 7 2 0 0
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New publication!!📑

Congrats to the Carell lab on their new paper:

"One-Step and universal Strategy for the Synthesis of Hypermodified Uracil Phosphoramidites acp3U and cmnm5U"

🔎Read more here: chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

2 months ago 2 0 0 0
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Publication alert!!📑

Congrats to the @dikiclab.bsky.social and Beli labs on their joint #SFB1361 publication, covering how DNA-protein cross-links promote cGAS-STING-driven premature aging and embryonic lethality.

🔎Read the paper here: www.science.org/doi/10.1126/...

2 months ago 4 1 0 0
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SFB 1361 member - Dr Andriana Kotini - will present a poster at "The Evil Within: Regulation and Repair of Endogenous DNA Damage" (IMB Mainz, 10-13 March 2026)👩‍🏫

Join us to connect, discuss and collaborate!
Details & registration: www.sfb1361.de/dnarepairconf2026

#SFB1361 #IMBMainz #ISC26DNArepair

2 months ago 3 1 0 0
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SFB 1361 member - Dr Natalie Schindler (@scientistwithheart.bsky.social) - shares a preview of her short talk at our upcoming conference 👩‍🏫

Dive into details at @imbmainz.bsky.social in Mainz this 10-13 March 2026!

Register now: www.sfb1361.de/dnarepairconf2026

#SFB1361 #IMBMainz #ISC26DNArepair

2 months ago 14 5 0 1

Preprint alert!!📑

We're happy to share a new preprint from our associated member, Dr Maximilian Reuter (@reuterlm.bsky.social), on

"Mechanisms of MCM2-7 helicase activation and initial DNA melting at near base-pair resolution" 

🔎Read more here: www.biorxiv.org/content/10.6...

2 months ago 3 1 0 0
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SFB 1361 member - Dr Carolin Wagner - will present a short talk at our upcoming conference 👩‍🏫

Don't miss out and come join her at @imbmainz.bsky.social!

Registration closes 02 Feb → www.sfb1361.de/dnarepairconf2026

#SFB1361 #IMBMainz #ISC26DNArepair

2 months ago 4 1 0 0
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Our speaker - Prof. Helle Ulrich - invites fresh perspectives on DNA repair & genome stability. 🧬

Continue the conversation at our conference "The Evil Within: Regulation and Repair of Endogenous DNA Damage." (IMB Mainz, 10–13 Mar 2026).

Register → www.sfb1361.de/dnarepairconf2026

4 months ago 13 5 0 0
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Meet the speakers!🎤

Session 6 "Replication Stress"

Chunlong Chen (Institut Curie) and Nynke Dekker (@nynkedekkerlab.bsky.social, Univ. of Oxford).

Registration via www.sfb1361.de/dnarepairconf2026 is ongoing!
See you in March at @imbmainz.bsky.social!

#ISC26DNArepair #SFB1361 #IMBMainz

4 months ago 1 3 0 0
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Meet the speakers!🎤

Session 5 "Features Driving Vulnerability"

Tony Cesare (@thecesarelab.bsky.social, CMRI), Julien Duxin (Univ. of Copenhagen), Fumiko Esashi (Univ. of Oxford), Lorenza Penengo (Univ. of Zurich) & Francesca Storici (Georgia Tech)

#ISC26DNArepair #SFB1361 @imbmainz.bsky.social

4 months ago 4 1 0 0
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Meet the speakers!🎤

Session 4 "Telomeres"

Fabrizio d'Adda di Fagagna (IFOM), Stephane Marcand (iRCM), Patricia Opresko (Univ. of Pittsburgh) & Teresa Teixeira (IBPC).

Register now via www.sfb1361.de/dnarepairconf2026 and come listen to them in Mainz!
#ISC26DNArepair #SFB1361 #IMBMainz

4 months ago 2 1 0 0

Loving @drewberry.bsky.social's beautiful animation of DNA break repair by HR - featuring the MRN complex architecture and function inspired by the research from @hopfnerlab.bsky.social!

Dive into the science behind it🧬
www.sciencedirect.com/science/arti...
www.nature.com/articles/s41...

4 months ago 11 2 0 1
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Meet the speakers!🎤

Session 3 "Ageing, Disease & Therapy"

Robert Hänsel-Hertsch (@epistrucstab.bsky.social, CMMC), Peter McKinnon (St. Jude's), Sven Rottenberg (@svenrottenberg.bsky.social, Univ. of Bern) & Björn Schwer (Univ. of California).

See you in Mainz!
#ISC26DNArepair #SFB1361 #IMBMainz

4 months ago 2 0 0 0

Publication alert!! 📃

Congratulations to the @hopfnerlab.bsky.social on the great work!

🔎Read the paper here: www.sciencedirect.com/science/arti...

4 months ago 1 0 0 0
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Meet the speakers!🎤

Session 2 "Gene Regulation & Chromatin Dynamics"

Sophie Polo (@polosophie.bsky.social, Univ. Paris Cité), Viviana I. Risca (@vivrisca.bsky.social, Rockefeller), Kikue Tachibana (MPI of Biochemistry) & Zhiguo Zhang (CUIMC).

Join us in March!
#ISC26DNArepair #SFB1361 #IMBMainz

4 months ago 4 1 0 0
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📢Abstract deadline extended to Mon, 15 Dec, 23:59 CET!

Good news! You now have a few more days to submit your abstract to present a short talk or poster at the IMB & SFB 1361 conference.

📑Find more info here: sfb1361.de/dnarepaircon...

#ISC26DNArepair #SFB1361 #IMBMainz

4 months ago 2 2 0 0
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Meet the speakers! 🎤

Introducing Session 1 "Double Strand Breaks", featuring

Petr Cejka (@cejkalab.bsky.social) from the Institute for Research in Biomedicine Bellinzona, CH and Boris Pfander from TU Dortmund, DE.

Register now and come hear them at @imbmainz.bsky.social!
#ISC26DNArepair #SFB1361

4 months ago 3 1 0 0

Don't forget - Early Bird Registration and Abstract Submission closes on 1 December.

Register now via www.sfb1361.de/dnarepairconf2026

We can’t wait to see you in March!
#ISC26DNArepair #SFB1361

4 months ago 0 0 0 0
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Rad53 regulates RNase H1, which promotes DNA replication through sites of transcription-replication conflict RNA-DNA hybrids and R-loops can lead to extensive DNA damage and loss of genomic integrity if not regulated in a timely manner. Although RNase H1 over…

📃Just published: new joint #SFB1361 publication by the Luke and Ulrich labs!

The article focuses on how Rad53 regulates RNase H1, which promotes DNA replication through sites of transcription-replication conflict.

🔎Find out more here:
www.sciencedirect.com/science/arti...

4 months ago 0 0 0 0
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We are excited to share that our #SFB1361 alumni, Dr Gabriel M. C. Longo, received a Walter Benjamin Fellowship to support his postdoctoral research in the Kleinstiver lab at Harvard Medical School/Massachusetts General Hospital, Boston.

Congratulations! 🎉🎉

5 months ago 3 0 0 0
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Identification of a Proteolysis‐Targeting‐Chimera that Addresses Activated Checkpoint Kinase‐1 Reveals its Non‐Catalytic Functions in Tumor Cells In cancer cells, the induction of DNA replication stress by HU activates CHK1 by autophosphorylation. This leads to cell cycle arrest and recruits the DNA repair protein WRN to promote DNA repair and....

📃Publication alert!!

Congrats to the Krämer lab on their new publication:

"Identification of a Proteolysis-Targeting-Chimera that Addresses Activated Checkpoint Kinase-1 Reveals its Non-Catalytic Functions in Tumor Cells"

🔎Read more about it here: onlinelibrary.wiley.com/doi/10.1002/...

5 months ago 0 0 0 0
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We’re excited to have Lorraine Symington and Stephen West as our keynote speakers - covering how cells repair DSBs during replication and how chromosomes are rebuilt via HR.

IMB & SFB 1361 Conference, 10–13 March 2026. Registration is live! #ISC26DNArepair #IMBMainz

5 months ago 3 1 0 0
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New publication!! 📑

Congrats to the Ulrich and @hopfnerlab.bsky.social labs on their latest work exploring how the INO80 chromatin remodeller facilitates DNA damage bypass via postreplicative gap repair.

🔎Read the paper here:
www.embopress.org/doi/full/10.1038/s44318-025-00580-4

6 months ago 4 1 0 1
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Registration is open!

Join us at IMB Mainz from 10–13 March 2026 for the 2nd International IMB & SFB 1361 Conference on "The Evil Within: Regulation and Repair of Endogenous DNA Damage".

Don't miss this conference and register now via www.sfb1361.de/dnarepairconf2026

#ISC26DNArepair #IMBMainz

6 months ago 5 4 6 3

It is with deep sadness that we share the news of the unexpected passing of our dear colleague and associated member Dr Nard Kubben last week.

We extend our heartfelt condolences to his family, friends, and all those who had the privilege of knowing him.

6 months ago 0 0 0 0

Publication alert!!📑

Congratulations to the @hopfnerlab.bsky.social, @yilanfan.bsky.social and @filizkuybu.bsky.social on the great work!

Read about it here: www.nature.com/articles/s41...

6 months ago 1 0 0 0
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Yesterday’s full-day workshop co-organised with @imbmainz.bsky.social focused on building a strategic approach to research funding for postdocs.

We’re proud to stand behind our postdocs as they shape the future of research!

#PAWde #PostdocAppreciationWeek2025 #IMBMainz

7 months ago 4 3 0 0
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The deacetylases HDAC1/HDAC2 control JAK2V617F-STAT signaling through the ubiquitin ligase SIAH2 - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - The deacetylases HDAC1/HDAC2 control JAK2V617F-STAT signaling through the ubiquitin ligase SIAH2

📃Just published: new #SFB1361 publication by the Krämer and Christmann labs!
The article focuses on how the deacetylases HDAC1/HDAC2 control JAK2V617F-STAT signaling through the ubiquitin ligase SIAH2.
Find out more here:
🔎 www.nature.com/articles/s41...

7 months ago 0 0 0 0