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RNF25 confers mRNA damage tolerance by curbing activation of the integrated stress response Excessive RNA damage activates cellular stress responses, triggering cell death. However, pathways that negatively regulate RNA damage responses are l…

New publication!📃

Happy to share the new joint publication by our #SFB1361 PI's Julian Stingele (@jstingele.bsky.social) and Petra Beli,

covering how RNF25 confers mRNA damage tolerance by curbing activation of the integrated stress response.

Read more here: www.sciencedirect.com/science/arti...

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Publication alert!!📑

Congrats to the @dikiclab.bsky.social and Beli labs on their joint #SFB1361 publication, covering how DNA-protein cross-links promote cGAS-STING-driven premature aging and embryonic lethality.

🔎Read the paper here: www.science.org/doi/10.1126/...

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SFB 1361 member - Dr Andriana Kotini - will present a poster at "The Evil Within: Regulation and Repair of Endogenous DNA Damage" (IMB Mainz, 10-13 March 2026)👩‍🏫

Join us to connect, discuss and collaborate!
Details & registration: www.sfb1361.de/dnarepairconf2026

#SFB1361 #IMBMainz #ISC26DNArepair

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That seems like quite a stretch: replication forks running into nicked DNA template parental strands forming seDSBs and then using telomeres to study the underlying repair mechanism...yes, a big story. My task: condense it into a 10 min talk to get the best feedback! #sfb1361

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SFB 1361 member - Dr Natalie Schindler (@scientistwithheart.bsky.social) - shares a preview of her short talk at our upcoming conference 👩‍🏫

Dive into details at @imbmainz.bsky.social in Mainz this 10-13 March 2026!

Register now: www.sfb1361.de/dnarepairconf2026

#SFB1361 #IMBMainz #ISC26DNArepair

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SFB 1361 member - Dr Carolin Wagner - will present a short talk at our upcoming conference 👩‍🏫

Don't miss out and come join her at @imbmainz.bsky.social!

Registration closes 02 Feb → www.sfb1361.de/dnarepairconf2026

#SFB1361 #IMBMainz #ISC26DNArepair

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Meet the speakers!🎤

Session 6 "Replication Stress"

Chunlong Chen (Institut Curie) and Nynke Dekker (@nynkedekkerlab.bsky.social, Univ. of Oxford).

Registration via www.sfb1361.de/dnarepairconf2026 is ongoing!
See you in March at @imbmainz.bsky.social!

#ISC26DNArepair #SFB1361 #IMBMainz

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Meet the speakers!🎤

Session 5 "Features Driving Vulnerability"

Tony Cesare (@thecesarelab.bsky.social, CMRI), Julien Duxin (Univ. of Copenhagen), Fumiko Esashi (Univ. of Oxford), Lorenza Penengo (Univ. of Zurich) & Francesca Storici (Georgia Tech)

#ISC26DNArepair #SFB1361 @imbmainz.bsky.social

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Meet the speakers!🎤

Session 4 "Telomeres"

Fabrizio d'Adda di Fagagna (IFOM), Stephane Marcand (iRCM), Patricia Opresko (Univ. of Pittsburgh) & Teresa Teixeira (IBPC).

Register now via www.sfb1361.de/dnarepairconf2026 and come listen to them in Mainz!
#ISC26DNArepair #SFB1361 #IMBMainz

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Meet the speakers!🎤

Session 3 "Ageing, Disease & Therapy"

Robert Hänsel-Hertsch (@epistrucstab.bsky.social, CMMC), Peter McKinnon (St. Jude's), Sven Rottenberg (@svenrottenberg.bsky.social, Univ. of Bern) & Björn Schwer (Univ. of California).

See you in Mainz!
#ISC26DNArepair #SFB1361 #IMBMainz

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Meet the speakers!🎤

Session 2 "Gene Regulation & Chromatin Dynamics"

Sophie Polo (@polosophie.bsky.social, Univ. Paris Cité), Viviana I. Risca (@vivrisca.bsky.social, Rockefeller), Kikue Tachibana (MPI of Biochemistry) & Zhiguo Zhang (CUIMC).

Join us in March!
#ISC26DNArepair #SFB1361 #IMBMainz

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📢Abstract deadline extended to Mon, 15 Dec, 23:59 CET!

Good news! You now have a few more days to submit your abstract to present a short talk or poster at the IMB & SFB 1361 conference.

📑Find more info here: sfb1361.de/dnarepaircon...

#ISC26DNArepair #SFB1361 #IMBMainz

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Meet the speakers! 🎤

Introducing Session 1 "Double Strand Breaks", featuring

Petr Cejka (@cejkalab.bsky.social) from the Institute for Research in Biomedicine Bellinzona, CH and Boris Pfander from TU Dortmund, DE.

Register now and come hear them at @imbmainz.bsky.social!
#ISC26DNArepair #SFB1361

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Don't forget - Early Bird Registration and Abstract Submission closes on 1 December.

Register now via www.sfb1361.de/dnarepairconf2026

We can’t wait to see you in March!
#ISC26DNArepair #SFB1361

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Rad53 regulates RNase H1, which promotes DNA replication through sites of transcription-replication conflict RNA-DNA hybrids and R-loops can lead to extensive DNA damage and loss of genomic integrity if not regulated in a timely manner. Although RNase H1 over…

📃Just published: new joint #SFB1361 publication by the Luke and Ulrich labs!

The article focuses on how Rad53 regulates RNase H1, which promotes DNA replication through sites of transcription-replication conflict.

🔎Find out more here:
www.sciencedirect.com/science/arti...

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We are excited to share that our #SFB1361 alumni, Dr Gabriel M. C. Longo, received a Walter Benjamin Fellowship to support his postdoctoral research in the Kleinstiver lab at Harvard Medical School/Massachusetts General Hospital, Boston.

Congratulations! 🎉🎉

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Last week, our amazing PhD student Dominik Stroh represented the lab at the 8th EU–US Conference on Endogenous DNA Damage & Repair in Trondheim, Norway 🧬🇳🇴
He nailed his poster and short pitch. Great job sharing your research with the international DNA repair community! 🙌
#DNArepair #SFB1361

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The deacetylases HDAC1/HDAC2 control JAK2V617F-STAT signaling through the ubiquitin ligase SIAH2 - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - The deacetylases HDAC1/HDAC2 control JAK2V617F-STAT signaling through the ubiquitin ligase SIAH2

📃Just published: new #SFB1361 publication by the Krämer and Christmann labs!
The article focuses on how the deacetylases HDAC1/HDAC2 control JAK2V617F-STAT signaling through the ubiquitin ligase SIAH2.
Find out more here:
🔎 www.nature.com/articles/s41...

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We’re excited to welcome Susanne Gerber from the University Medical Center Mainz as an associated member of the #SFB1361! 🎉
Her expertise in bioinformatics and cutting-edge nanopore sequencing protocols will advance genomic and epigenomic research within our network.

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We‘re proud to share that our #SFB1361 PhD student, Yilan Fan from the @hopfnerlab.bsky.social, has been awarded a poster prize at the CNIO-CaixaResearch Frontiers Meeting “Machines on DNA and RNA: A Molecular Mechanistic Perspective“ held on 28-30 May 2025 in Madrid, Spain.
Congrats! 🎉

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Last week our #SFB1361 members gathered in Würzburg to discuss and plan for the 3rd funding period.

This 3-day retreat led to many fruitful discussions and fresh ideas! Now its time to put these ideas to work! 🔬⚗️🧬

#scientificretreat #planning #DNArepair

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Our members came from Mainz, Frankfurt, Darmstadt, and Munich to Würzburg for this retreat to discuss, network, and plan for the next years.
We also took the opportunity to visit the Würzburg Residence and immerse ourselves in the art, culture, and history!

#würzburg #SFB1361 #retreat

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Poster presentations, discussions, and networking.
Of course, our PhDs and Postdocs are also very much involved in this retreat.

#SFB1361 #DNArepair #scientificretreat

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Our #SFB1361 is away on #retreat from today until Wednesday!

Starting off the day with most of us travelling by train to Würzburg and plenty of project updates in the afternoon!

Excited to plan for the next years and the next funding period!

#ecofriendly #worktravel
#dnarepair

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Our RMU Master Module on DNA Repair & Genome Stability starts today with the first lecture from Prof Brian Luke!
#SFB1361 #DNArepair #RMU

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Pre-print alert from @hopfnerlab.bsky.social!

Great job! Read more about it here: www.biorxiv.org/content/10.1...

#DNArepair #SFB1361

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It is the "International Day of Women and Girls in Science"!

We celebrate the recent achievements and successes of our SFB 1361 female PIs!
Speaker - Helle Ulrich
Member - Sandra Schick
Assoc. member - Siyao Wang

Find out more: www.sfb1361.de/about/news
#WomenInScience #STEM #SFB1361

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We are very happy to jointly host with @imbmainz.bsky.social our new collaborators coming from UNIST, Ulsan, Korea. Today and tomorrow we will have a symposium at IMB to kick off this collaboration!
#science #dnarepair #SFB1361

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