Cryo-EM reveals an extrahelical allosteric binding site at the M5 mAChR pubmed.ncbi.nlm.nih.gov/40745154/ #cryoEM

Our latest paper, a whirlwind combination of mutagenesis, GaMD and cryo-EM to find new allosteric binding sites at the M5 mAChR.

www.nature.com/articles/s41...

An honour and privilege to share my work in this session!

Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR - Nature Communications The drug Xanomeline is progressing through clinical trials for the treatment of patients with schizophrenia. Here, the authors determine a cryo-EM structure of Xanomeline bound to its primary target r...

Starting to become common!
www.nature.com/articles/s41...