Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social
doi.org/10.1016/j.ce...
Read the thread👇 for the highlights of our findings.

Double ERC success for DKFZ researchers With its Proof of Concept (PoC) grants, the European Research Council (ERC) supports scientists in further developing the economic potential of their research results. Two scientists from the German C...

Double ERC success for DKFZ researchers: Hellmut Augustin @hellmutaugustin.bsky.social and Michael Platten @michael-platten.bsky.social have been selected by the European Research Council @erc.europa.eu for the prestigious Proof of Concept (PoC) grants. #ERCPoC 👏
t1p.de/zau31

A double-edged sword: Chronic cellular stress promotes liver cancer - but at the same time renders tumors vulnerable to immunotherapy A key molecular mechanism drives the growth of liver cell cancer while simultaneously suppressing the body's immune response to the tumor. This has now been published in the journal Nature by a team l...

Researchers from DKFZ, University Hospital of Tübingen and @sbpdiscovery.bsky.social discovered that chronic cellular stress promotes liver cancer - but at the same time renders tumors vulnerable to immunotherapy. @nature.com
t1p.de/1vosw

The @dkfz.bsky.social PhD Program is open, and the Mall Lab is recruiting PhD students.
1: in vivo and organoid models to study and treat autism associated disorders.
2: cancer cell plasticity in brain tumors using single cell genomics and perturbation screens.
Apply now: www.dkfz.de/en/career/in...

Werden Sie Teil unseres Teams!
Become part of our team!

💡Die Health + Life Science Alliance Heidelberg Mannheim sucht ab sofort in Vollzeit:

👩🏻‍🔬Referent∗in👨‍🔬 (w/m/d)
Bewerbungen als PDF-Datei bis 30.11.2025 an: andrea.leibfried@bioquant.uni-heidelberg.de
adb.zuv.uni-heidelberg.de/info/INFO_FD...
#job

Thanks!

Presenting recipients of our 2025 Stimulator Grant:
👉TACTICS: Thalamocortical Assembloids and Computational Tools for Investigating Cellular Signatures in #Autism.
🧠How do autism-linked mutations disrupt early brain development? @moritzmall.bsky.social @steglelab.bsky.social
@dkfz.bsky.social

Looking forward to this collab with @moritzmall.bsky.social and Barbara Treutlein!

We’ll generate high-throughput multi-modal CRISPR data on ASD risk genes in 🧠 organoids & assembloids, and build an ML model of gene regulation dynamics to analyze the data and enable future in silico experiments.

No GPS in the head: How the brain flexibly switches between internal maps Since their discovery in 2004, the grid cells in the brain, which are important for our orientation, have been regarded as a kind of “GPS in the head.” However, scientists at the German Cancer Researc...

Since their discovery in 2004, the grid cells in the brain have been regarded as a kind of "GPS in the head." However, scientists at DKFZ and Heidelberg University Hospital have now shown that grid cells work much more flexibly than previously assumed. @nature.com Neuroscience
t1p.de/hpj1m

🚨 Registration deadline for the EACR conference on #cancerneuroscience is September 15 ‼️

Please join us in beautiful Bilbao for exciting discussions on the dialogue between the nervous system and cancer 🔬🧠

See you soon!

Thanks Leo!

Thanks, Sandra!

Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis - Nature Genetics This study identifies candidate safeguard repressor transcription factors that repress alternate lineages in mature cell types and provides functional evidence that Prox1 performs such a function in h...

Thank you @gscnoffice.bsky.social and the selection committee for the GSCN 2025 Best Publication Award recognizing our joint work: www.nature.com/articles/s41... Proud of the team & all co-authors. Grateful to @dkfz.bsky.social and @embl.org for the support. See you in Munich!

‪GSCN 2025 Best Publication Award goes to B. Lim, @moritzmall.bsky.social, J. Zaugg, A. Kamal @biomedizin.unibas.ch for joint publication in @naturegenz.bsky.social All infos on www.gscn.org @dkfz.bsky.social @www.helmholtz-munich.de @embl.org @mdc-berlin.bsky.social @bihatcharite.bsky.social

Bild: Jung/DKFZ

Den GSCN 2025 Publication of the Year Award erhält @moritzmall.bsky.social zusammen mit Bryce Lim und weiteren Co-Autoren für ihre Veröffentlichung "Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis". 👏
@gscnoffice.bsky.social

🎉 Herzlichen Dank für den @gscnoffice.bsky.social-Preis „Publication of the Year 2025“ zu unserer @natgenet.nature.com Publikation: www.nature.com/articles/s41...
Diese Auszeichnung ist echte Teamleistung—danke an alle Mitwirkenden. Auf zu den nächsten Schritten im Kampf gegen Krebs!

Thanks, Frank!

🚨 @dkfz.bsky.social Postdoctoral Fellowships 2025 — Postdoc opening (Mall Lab)
Work at the interface of neurodevelopment, epigenetic repression & cancer neuroscience.
Apply: jobs.dkfz.de/en/jobs/1679...
#Postdoc #Plasticity #Neurodegeneration #CancerNeuroscience

Application - Helmholtz Information & Data Science Academy

We're seeking a PhD student passionate about ML, biology, and driving impact in healthcare!

You'll be working on multi-omics factorization models for personalized medicine, co-supervised by @junyanlu.bsky.social.

👉 Project: www.helmholtz.de/assets/hidss...
✍️ Apply: hidss4health.de/application

Hands down the best meeting this year so far! Thanks for the fantastic organization @matlupien.bsky.social @shenhui1986.bsky.social Bonus was a musical finale - who said science cannot be fun :)

An insightful thread for the second study by the one and only @manusaraswat.bsky.social that spearheaded this superstar team effort together with @lauraruedag.bsky.social and Elisa Heinzelmann in the labs of @oliverstegle.bsky.social and me:
bsky.app/profile/manu...

Detailed thread for the first study from the overall leader of this truly collaborative effort, the amazing @bayraktarlab.bsky.social: bsky.app/profile/bayr...

What keeps cancer cells in check—and can we tame them? In 2 collaborative preprints, we trace glioblastoma cell transitions in space and decode what regulates their plasticity 🧠👇
📍 Spatial & multi-omic atlas: www.biorxiv.org/content/10.1...
📍 Regulatory logic: www.biorxiv.org/content/10.1...

Decoding Plasticity Regulators and Transition Trajectories in Glioblastoma with Single-cell Multiomics Glioblastoma (GB) is one of the most lethal human cancers, marked by profound intratumoral heterogeneity and near-universal treatment resistance. Cellular plasticity, the capacity of cancer cells to t...

13/ Want to learn more? Read our regulatory paper www.biorxiv.org/content/10.1... and companion spatial multi-omics study www.biorxiv.org/content/10.1...
Watch out for thread from @bayraktarlab.bsky.social on mapping conserved spatiotemporal trajectories of GB

🧠 Excited to share my main PhD project! We mapped the regulatory rules governing Glioblastoma plasticity using single-cell multi-omics and deep learning. This work is part of a two-paper series with @bayraktarlab.bsky.social @oliverstegle.bsky.social and @moritzmall.bsky.social, Preprint at end🧵👇

How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵

Thank you, @hlsalliance.bsky.social! Your backing lets junior teams like ours pursue fundamental, high-risk research to better understand cancer. Excited to keep advancing the frontiers together with many collaborations within the Alliance.

I am very grateful to @uniheidelberg.bsky.social and the Hella Bühler Foundation for this honour. Sharing the prize with the brilliant @venkataramanilab.bsky.social and our amazing teams makes me extremely proud. I am excited to channel this prize into the next wave of cancer-fighting ideas!

Bild: Jung/DKFZ

Ausgezeichnet für herausragende #Krebsforschung: Den mit 100.000 Euro dotierten diesjährigen Hella Bühler-Preis teilen sich Moritz Mall, DKFZ und Hector Institut für Translationale Hirnforschung, und Varun Venkataramani vom Universitätsklinikum Heidelberg. 👏 @moritzmall.bsky.social
👉 t1p.de/1dnqw

Vielen Dank für die große Ehrung und die starke Unterstützung durch das @dkfz.bsky.social
, das Hector Institut & alle Partner! Gemeinsam treiben wir in Heidelberg die Krebsforschung voran – die spannendsten Entdeckungen kommen erst noch. 🙏🔬 #HellaBühlerPreis #TeamScience