Toward Personalized Medicine in Type 1 Diabetes: Understanding How Patient Heterogeneity Influences Therapeutic Efficacy Pharmacologic interventions for type 1 diabetes (T1D) have advanced significantly in recent years with the advent of the first FDA approved therapy teplizumab for delaying symptomatic disease onset i...

How are we learning from #T1D trials and moving towards precision medicine? Congrats 🎉to Jasmine in the lab on writing a fantastic review article on this topic at Diabetes, Obesity and Metabolism!
dom-pubs.onlinelibrary.wiley.com/doi/10.1111/...

Live human pancreas slice with islet cells stained red.

With the potential to limit T cell activity locally, a new drug called ImmTAAI may enable targeted immunoregulation treatment for type 1 diabetes.

Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/3NQusPc

Beyond bystanders: How β cell stress shapes the autoimmune response in T1D β cell stress not only drives loss of functional β cell mass but also may fuel autoimmunity in type 1 diabetes.

I’m excited to share that our review article, co-authored with my colleague Dr. Decio Eizirik, is out today in Science Translational Medicine.

www.science.org/doi/10.1126/...

We are very excited for the next Zoom seminar of Metabolism in Development & Physiology!

12th of March, 3pm CET/ 2pm GMT/ 9am EST

Our speakers are:
Kathryn Wellen (University of Pennsylvania)
Saraswathi Pillai (Columbia University)

Sign up to get the Zoom link: docs.google.com/forms/d/e/1F...

Single-cell and isoform-specific translational profiling of the mouse brain - Nature Post-transcriptional regulation of mRNA translation was explored using Ribo-STAMP and single-cell RNA sequencing to reveal cell-type-specific and isoform-specific translation patterns across hipp...

Chuffed to see our paper with @geneyeo.bsky.social finally published in @nature.com.
www.nature.com/articles/s41...
Very grateful to Fede, Susie, and Dave from my lab, and Sammi, Eric, and Pratibha from Gene's lab. What did we find? ⬇️ ⬇️ ⬇️

I’m so excited to share that I’ve accepted an assistant professor position at the University of Colorado Anschutz, BMG department and Barbara Davis Diabetes center! I’m so grateful to many who have helped me get here, especially mentors at Joslin, @hmsbpa.bsky.social @leadingedgeprogram.bsky.social

DEC1 regulates human β cell functional maturation and circadian rhythm Preza et al. show that DEC1, a circadian clock regulator, promotes mature insulin responses to glucose stimulation in human stem cell-derived islet organoids. DEC1 is restricted to maturing β cells, w...

The transcription factor DEC1 links #circadian rhythms to human β cell maturation, highlighting the essential role of circadian control in generating fully functional SC- #islet organoids #stemcells www.cell.com/cell-reports...

Apply to give a talk on Metabolism in Development and Physiology

💥Call for Speakers💥
Hey metabolism enthusiasts!
Do you, or someone you know, dive into the fascinating world of metabolism?
🔬 We are seeking speakers for the Metabolism in Development & Physiology seminars! Showcase your work & connect with our community!
👉 Apply at:
docs.google.com/forms/d/e/1F...

Islet Biology and Diabetes: Beta Cell Compensation, Failure and Recovery | Keystone Symposia Join us at the Keystone Symposia on Islet Biology and Diabetes: Beta Cell Compensation, Failure and Recovery, March 2026, in Breckenridge, with field leaders!

Deadlines are approaching (some next week!) for @keystoneSymposia.bsky.social #IsletBiology & #Diabetes : #BetaCell Compensation, Failure & Recovery, this March in Breckenridge! See scholarship, abstract and discount reg dates: keysym.us/KSDiabetes26 #KSDiabetes26

Schematic of the competitive catabolism model

Excited to share my latest postdoc work on systemic metabolic homeostasis! We show that nutrient consumption fluxes compete, and this competitive catabolism helps explain why obesity drives diabetes. Explore the model with our interactive web app: compcat.princeton.edu

doi.org/10.1101/2025...

🚨Excited to kick off our online seminar series on Metabolism in Development and Physiology!

Please help us grow a collaborative and supportive community by joining (<1min): forms.gle/Y8QzucogKKrZ...
#Metabolism #Development #StemCells

Please RT! 🙏

Love these beautiful pictures! Congrats to Laith et al!!

Excited to share our Commentary in JCI. Exploring how SIRT2 regulates human beta cell proliferation
www.jci.org/articles/vie...
@jci.org

It's great to see the final version of our SIRT2 paper in JCI along with an astute commentary from trailblazers in beta cell regeneration—thanks for highlighting our work! @likatz.bsky.social @donaldscottmssm.bsky.social @jci.org @sanderlaberlin.bsky.social tinyurl.com/y6rx69x7 tinyurl.com/ydvv9u2s

Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis Huber et al. used live pancreas slices from donors with recently diagnosed type 1 diabetes to reveal beta cell dysfunction independent of local immune cells. Real-time imaging and molecular analyses u...

I am excited to announce our paper “Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis” is out in Cell Reports! @eaphelps.bsky.social
www.cell.com/cell-reports...

Join us for the 2025 Rachmiel Levine-Arthur Riggs Diabetes Research Symposium. We have an amazing program this year focusing on type 1 #diabetes. We have also extended the abstract submission deadline to Sept 19. Register and submit your abstract a www.levinesymposium.com

It was great fun to write this review with friends and colleagues Melkam Kebede, Belinda Yau, @jinghughes.bsky.social and Julien Ghislain

Glycemia Shift Pancreatic Islets Rhythmicity via δ-α Cell in vivo, Impairment in Diabetes Blood glucose homeostasis relies on the well-coordinated rhythmic activity of millions of islets throughout the pancreas. Islet rhythmicity is triggered by glucose elevation and mediated by paracrine ...

Simultaneous in vivo calcium imaging of up to 100 islets coupled with CGM measurements in lean and ob/ob mice—this is impressive! www.biorxiv.org/content/10.1...

Thanks for the kind words Scott!

Based on these preclinical studies, we consider SIRT2 a promising target for stimulating beta cell regeneration in diabetes. Thank you NIH & Breakthrough T1D for funding, @iidp.bsky.social for islets, and collaborators Orian Shirihai, Kristen Wells, @goniaguy4.bsky.social, & @auwerx-lab.bsky.social!

Mechanistically, SIRT2 deacetylates glycolytic and TCA enzymes, dampening islet oxygen consumption during hyperglycemia. In addition to its direct effect on metabolism, SIRT2 impacts how beta cells transcriptionally interpret hyperglycemia as a stress.

We show that inactivation of SIRT2 increases beta cell proliferation in mice when glucose is elevated above the physiological set point, indicating SIRT2 dampens adaptive beta cell proliferation. SIRT2 also restrains human beta cell proliferation but over a broader range of glucose concentrations.

First off, huge shoutout to co-first authors Bastian Ramms, Chun Zeng, and Jackie Benthuysen from Maike Sander’s lab, and to those who helped with revision experiments including my new colleagues at @cuanschutz.bsky.social @cudevbio.bsky.social

Out today in @jclinical-invest.bsky.social! We discovered a novel regulator of adaptive beta cell proliferation, the protein deacetylase SIRT2, that acts through a metabolic mechanism. Bluetorial below (1/5).
tinyurl.com/ydvv9u2s

With credit to @huisinglab.bsky.social for inspiring the tradition, today we bid farewell to our very first lab member Sean Lee who is joining the Cell Biology, Stem Cells, and Development PhD program here at @cuanschutz.bsky.social‬. Best of luck Sean, we expect great things from you!

VDAC1 is a target for pharmacologically induced insulin hypersecretion in β cells β cells are dysfunctional in type 2 diabetes (T2D) and congenital hyperinsulinism (HI), but the mechanisms linking hypersecretion to β cell failure ar…

These are two important papers that profile beta cell excitotoxicity in response to a sulfonylurea or the VDAC1-stabilizing molecule SW016789. Comparing these studies should make for an excellent journal club. Congrats to all authors! @kalwat.bsky.social tinyurl.com/fwrzrtk9 tinyurl.com/3nzfsp79

Glucose metabolism and regulation in establishing human stem cell-derived β cell maturation Efforts to generate mature stem cell-derived β (SC-β) cells have been ongoing for decades, yet their functional performance still falls short of prima…

Review on metabolism in stem cell derived beta cells from former PhD student with us, Frank Lin. Cell Reports @cp-cellreports.bsky.social

www.sciencedirect.com/science/arti...

How do non-coding variants in enhancers lead to disease? Happy to share our recent work, led by @ewholling.bsky.social, in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease. www.biorxiv.org/content/10.1... 1/

Autoreactive T Cells and Cytokine Stress Drive β-Cell Senescence Entry and Accumulation in Type 1 Diabetes Type 1 diabetes (T1D) results from a complex dialogue between the immune system and islets characterized by T cell–mediated autoimmune destruction of pancr

Very excited to share new work on the origins of beta cell senescence in #T1D led by talented PhD student Jasmine Pipella! 🥂🎉 online today!

diabetesjournals.org/diabetes/art...

The U.S. Lit a Beacon for Science. Under Trump, Scientists Fear It’s Dimming

Talked to @KateZernike at @nytimes about my journey and the current moment for scientists in the U.S.

“Ardem Patapoutian’s story is not just the American dream, it is the dream of American science.”

Read the article here. No subscription required:

www.nytimes.com/2025/06/03/u...