Cell-type-targeted mitochondrial transplantation rescues cell degeneration - Nature MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.

Last 2 weeks of research on #Mitochondria in #Health and #Disease! 📚
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...

Among highlights 👇
www.nature.com/articles/s41...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Therapeutic mitochondria transplants made more efficient with targeting tool A system of protein binders directs energy-generating organelles to targeted cells, potentially improving ways to treat mitochondrial dysfunction.

A system of protein binders directs energy-generating organelles to targeted cells, potentially improving ways to treat mitochondrial dysfunction

go.nature.com/42bk2wX

Cell-type-targeted mitochondrial transplantation rescues cell degeneration - Nature MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.

Nature research paper: Cell-type-targeted mitochondrial transplantation rescues cell degeneration

go.nature.com/4thFlZM

Cell-type-targeted mitochondrial transplantation rescues cell degeneration - Nature MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.

The mitochondrion-targeting tool MitoCatch brings mitochondria into specific cell types through cell-surface-targeted binders #NBThighlight www.nature.com/articles/s41...

I would like to thank all collaborators and the amazing team involved in this work. Deeply grateful to @vmorenojuan.bsky.social for this very exciting collaboration and Botond Roska @iobswiss.bsky.social for great support. (7/7)

After delivery, donor mitochondria are efficiently internalized and can escape endocytic vesicles. Using MitoCatch, we delivered healthy mitochondria to injured retinal ganglion cells and achieved increased cell survival and functional rescue of these neurons in vivo. (6/7)

In collaboration with Prof. Müller’s lab at ETH, we also developed an atomic force microscopy–based method to measure mitochondrion–cell interactions at single-molecule resolution, revealing how these binders enhance mitochondrial adhesion to the cell surface. (5/7)

We illustrated the possibility to use any protein binder types including nanobodies, full antibodies and synthetic binders. By modifying binder affinity and avidity we can efficiently tune the targeting efficiency. (4/7)

We engineered a system that uses protein binders to guide mitochondria to defined targets and promote their internalization. We introduced several concepts how protein binders can be used for efficient mitochondrial delivery. (3/7)

Many central nervous system diseases are driven by mitochondrial dysfunction and show cell-type-specific vulnerability. While mitochondrial transfer is an exciting therapeutic concept, efficiently delivering mitochondria to specific cells has remained a major challenge. (2/7)

Excited to share that our technology for cell-type-targeted mitochondrial delivery is published in
@Nature
www.nature.com/articles/s41...
In this work, we introduce MitoCatch, a platform that enables programmable, targeted delivery of donor mitochondria to specific cell types. (1/7)

In vivo single-cell gene editing using RNA electroporation reveals sequential adaptation of cortical neurons to excitatory-inhibitory imbalance The balance between excitatory and inhibitory neurotransmission is fundamental for normal brain function, yet the adaptation of individual neurons to disrupted excitatory-inhibitory balance is not wel...

Gene editing of single, targeted neurons in vivo is now feasible. We are proud to present our preprint for highly efficient single-cell electroporation using RNA. With @alex-fratzl.bsky.social, @munzlab.bsky.social, Botond Roska @iobswiss.bsky.social
#neuroskyence
www.biorxiv.org/content/10.1...

Single-cell electroporation is performed via patch pipette and under 2-photon visual guidance in vivo. A short voltage pulse train is applied through the pipette to deliver RNA molecules into a targeted cell. The video below shows this process in cortical neurons expressing GCaMP6s.

🧬👁️Discover how research and patient care come together in the latest Novartis Live magazine — with stories from the labs and clinics shaping the future of vision.

🔗 bit.ly/4km6XZ0

#IOB #VisionScience #TranslationalResearch #Basel #Ophthalmology #AcademicSky #Novartis

Joint visual-vestibular computation of head direction and reflexive eye movement Several cognitive maps have been identified, but what sensory signals drive them and how these are combined are not well understood. One such map, the head-direction representation, is believed to be ...

How do different sensory signals combine in the computation of cognitive maps? I’m thrilled to share our new preprint, in which we investigate this question in the context of the head-direction system:
www.biorxiv.org/content/10.1...

✨Thrilled about our new publication in Nature Medicine! We are excited to offer a potential new avenue for treating Stargardt disease!
Read the paper here: nature.com/articles/s41...
Watch the video: iob.ch/fileadmin/ge...
Press release here: iob.ch/news-view-al...

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We are pleased to share that RhyGaze, IOB's first spin-off, has secured Series A funding with an USD 86 million investment to advance vision restoration therapy.

Read more: iob.ch/news-view-al...

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