So very pretty! Iba1, Cmec7a, Amylo-glo. Courtesy of @clairashley.bsky.social

Congratulations to our Markesbery Symposium Scientific Session winners!
@ukresearch.bsky.social

new preprint from @iostephens.bsky.social describes the potential benefits of increasing lipid turnover in microglia by eliminating PLIN2 from their surface

Are you an ATP!?!

We are hosting our 2nd annual CNS MET Symposium 12/3/25 and are searching for early-career researchers to highlight as All-star Trainee Presentations (ATPs).

Up to 4 individuals will be invited for an all-expense paid trip to beautiful Lexington KY.

Apply here! rb.gy/3zk4cm

Senator Murray Slams Trump Admin for Choking Off Lifesaving NIH Medical Research - Senator Patty Murray Washington, D.C. – Today, U.S. Senator Patty Murray (D-WA), Vice Chair of the Senate Appropriations Committee, issued the following statement on reports today that President Trump’s Office of Manageme...

BREAKING: Trump wants to illegally cut off $15 billion in lifesaving NIH research.

Research to cure cancer, Alzheimer's, and so much more is on the line.

These people are LYING about waste, fraud, and abuse at NIH to justify attacking medical research—we all need to say so.

My full statement. ⬇️

Trump administration blocks NIH from awarding any research grants and contracts The order applies to the entirety of new and, possibly, ongoing research grant dollars that go to universities and academic medical centers.

#Breaking: Trump administration blocks NIH from awarding any research grants and contracts
www.statnews.com/2025/07/29/t...

This is figure 1, which shows DDHD2 lipase localizes to synaptic terminals in the hippocampus.

A study in Nature Metabolism shows that under glucose-depleted conditions, neurons can use fatty acids as an alternative source of energy to support synaptic function. go.nature.com/44T8kct 🧪

Or at least that's how I'm interpreting their decision and the law.

No, the NIH indirects are included in the APA and the SCOTUS specifically said it does not apply to those. And they only limited nationwide injunctions and didn't eliminate them entirely. A federal judge could rule that the indirect cost cap violates the APA and vacate the policy across the country.

High-Resolution Spatial Profiling of Microglia Reveals Proximity Associated Immunometabolic Reprogramming in Alzheimers Disease Single-cell RNA sequencing has demonstrated that the presence of parenchymal amyloid plaques and intracellular hyperphosphorylated tau pathology is associated with distinctive (and possibly disease-dr...

New pre-print out:

www.biorxiv.org/content/10.1...

Surprise surprise 🤗, microglia proximity to AD pathology alters their immunometabolic signatures

Excellent work by Kai Saito and our team, along with our awesome collaborators Pete Nelson, @macauleylab.bsky.social, @johnsonlab.bsky.social

A polygenetic rat model of divergent aerobic capacity reveals a liver–brain interaction impacting Alzheimer's disease‐like phenotypes Abstract figure legend This study examined the effects of aerobic capacity diet, and sex on brain and liver health in the context of the Alzheimer's disease (AD) biomarker amyloid beta (Aβ42). The da....

My first, first author publication is out now in @jphysiol.bsky.social physoc.onlinelibrary.wiley.com/doi/10.1113/...

Trachsel-Moncho, @annesimonsen.bsky.social et al. identify the endosomal protein SNX10 as a modulator of piecemeal #mitophagy of OXPHOS machinery components and mitochondrial homeostasis. rupress.org/jcb/article/...

@cancelluio.bsky.social @arcticautophagy.bsky.social

How Insects Changed The World—And Human Cultures In “The Insect Epiphany,” an entomologist explores the history of insects in art, food, engineering, and more.

“We can look to venom, surprisingly, to aid us biomedically," says Dr. Barrett Klein. "For example, bee venom therapy has been used for arthritis, arthralgia, Parkinson’s, ALS, multiple sclerosis, and other conditions.”