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Restoring resident tissue macrophages to combat aging and cancer - Nature Aging Park and colleagues propose a conceptual framework in which dysregulation of resident tissue macrophages is both a central contributor to how an aging immune system causes diseases, including cancer, ...

Thrilled our Perspective in @nataging.nature.com is out! With Matthew D Park et al., we spotlight how aging reshapes RTMs and skews myelopoiesis–with consequences for healthy aging and cancer @miriammerad.bsky.social www.nature.com/articles/s43...

New preprint out! 🚀Spearheaded by @chiarafalcomata.bsky.social we could show how pancreatic cancer cells evade the immune system by modulating their TME with the extracellular factors Serpine1 (PAI-1) and Serpinb2 (PAI-2)! #PertrubMap #PDAC

Hi Jon! Could you add me too?

Ovarian cancer-derived IL-4 promotes immunotherapy resistance Cancer-derived paracrine factors create distinct “neighborhoods” in the tumor microenvironment, promoting clonal selection and tumor heterogeneity. In ovarian cancer, IL-4 originating from a minority ...

First lab Bluesky post! Happy to share new papers:

PRINT: Using Perturb-map, we show in @cellpress.bsky.social how ovarian tumors resist immunotherapy > www.cell.com/cell/abstrac...

PREPRINT We developed a new technology to easily generate cell-targeted LNP-RNA > www.biorxiv.org/content/10.1...

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Very honored to be inducted at the Belgian Royal Academy of Medicine this weekend alongside incredible colleagues. Thank you again to the Academy for honoring my laboratory. It was also refreshing to spend time with like-minded peers amidst all the chaos,

Nutrient-driven histone code determines exhausted CD8+ T cell fates ACLY-deficient CAR T cells targeting the tumor-associated antigen disialoganglioside GD2 (GD2 CAR T cells) also resisted acquiring TEX-like properties, exhibiting reduced CD39 expression when co-cultu...

Here is link to Shixin's new paper: www.science.org/doi/epdf/10....

That’s great! Could you add me please🧬

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1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...

Congrats! Exciting story