In February 1777, General George Washington ordered the first mass immunization campaign in American history by mandating that his troops be inoculated against smallpox. He protected the Continental Army from an epidemic that was deadlier than British forces.
249 years later, we have this idiot.
I think most people would prefer this. #Science
It's really something to be living through the worst President, the worst Supreme Court, and the worst Congress all at once
www.golocalprov.com/business/nab... #nabsys
Throughout my entire Canadian Military Career I served alongside USAF personnel daily. We were a team, brothers and sisters in support of one goal, maintaining North American air sovereignty. More than colleagues, we were best friends, I bet many feel the same to this day.
This all day Long 👇
A graph titled “the public health success of the measles vaccine” that shows the number of measles cases in the United States plummeting after the vaccine was introduced in 1963
I showed this graph in class yesterday on how measles cases in the United States plummeted dramatically after the vaccine was licensed in 1963. It’s not subtle and I could not resist observing: “This stunning design in measles cases was not thanks to vitamin A. It was not due to beef tallow.”
This is an excellent summary of current circumstances
Kyle Kulinski: “A sundowning president with Alzheimer’s who’s a malignant narcissist is dragging us into WWIII, committing war crimes on a daily basis and crashing the global economy, and nobody is actually grabbing the steering wheel.”
Tens of thousands marching in Providence today. No kings.
Spread this dear ones:
"Bernie Sanders is suggesting the Epstein files be read during the filibuster on the SAVE Act this week.
Let's get this to TREND!
Answered that for you
Nabsys: Snow or rain in the forecast? We’ve got you covered - literally. Stop by our booth #2007 and grab an umbrella before heading out!
👉 Visit us on the trade show floor or book a meeting with us: hubs.ly/Q046BKDj0
#ACMG #ACMG26 #ACMGMtg26 #GenomicResearch #EGM
This would be a crime against humanity, but otherwise I agree.
.
> @covie93.bsky.social
will be back at same site in Orlando next year, March 1-4, 2027
#AGBTGM26
Beth Shapiro and Len Pennacchio to make closing remarks.
That's it! Thanks for coming. Any feedback?
#AGBTGM26
JO: DIstinct genomic compartmentalization of hypo- and hyper-methylation in cancer. Tumors share methylation states across distinct lineages. May be able to subtype cancers, use for liquid biopsy for tumor origin, identify cancer specific regulatory alterations
#AGBTGM26
JO: Are there conserved methylation across cancers or cancer-type profiles? Contaminating cell types can obscure patterns. Can deconvolve cell types.
#AGBTGM26
JO: see focal hypermethylation and global hypomethylation.
Cancer atlas has data on 450K sites, only 1-2% fo methylome. Can now do whole methyome. Looked at 106 tumors from 21 cancer types
#AGBTGM26
James Occean from Stanford will discuss whole genome profiling DNA methylation in primary tumors. Epigenetic alterations extensive in cancer
#AGBTGM26
YM: longer reads can be better assigned to maternal/paternal allele to see imprinting
#AGBTGM26
YM: use 5' kit and do long read 1. See extra cap G not genomically encoded in reads if goes all the way to 5' end. Do not see with premature termination to remove noise. See major start site but can also now see minor start sites previously hidden in noise
#AGBTGM26
Yasuhiro Murakawa from Kyoto talking about spatial transcriptomics technology for transcription start site profiling
#AGBTGM26
JB: another patient has main outlier at AS3MT, implicated in broad set of neuropsychiatric disorders. Depletion leads to increase in nerve, brain and muscle transcripts
#AGBTGM26
JB: Use CRISPR guides to remove highly expressed RNA. 400,000 guides made. See highly expressed genes go down, poorly expressed go up. Uncover novel splice sites as in KCNJ6 only identified in depletion
#AGBTGM26
JB: Of those with rare disease tested, 25-50% get a causal variant. RNAseq used to help interpret DNA mutations
#AGBTGM26
Jon Bezney from Stanford will talk about rare disease diagnostics especially using RNAseq
#AGBTGM26
EK: you can sign up your pet for pets on the ark. Free to sign up, $150 if want to have sequenced
#AGBTGM26
EK: Are cats domestic? Yes, 4000 yrs ago: Evolution in response to an anthropogenic niche. A domestic population requires acces to that niche.
#AGBTGM26
EK: Panagram counts kmers to compare genomes. very fast way to compare similarity. Highly correlated with Minimap
#AGBTGM26
