Breast cancer brain metastases don’t just invade the brain, they rewire it!
Our new review covers how metastatic breast cancer cells hijack neurotransmitters, synapses, astrocytes, and calcium signaling, to thrive in the brain. Possibly through #Cytonemes and #TNTs !
www.mdpi.com/3849806
Cells use proteins like morphogens to talk to each other in order to build and maintain 3D tissue structures. But how do these morphogens reach distant cells when they are all packed together? We think long #cytonemes play a big role in shaping how cells talk to one another for growth.
Umm, what about insurance.
As spooky season is upon us 🎃, we have cells that look like spider webs for #FluorescenceFriday 🧪🔬
🚀 Exciting MSc opp @ UManitoba! Join 2 interdisciplinary labs (bioinformatics + cancer bio) on a CIHR-funded ovarian cancer project. Gain hands-on training in single-cell genomics & molecular biology. See advertisement to apply #GradResearch #Cancer
Great talk from @hc327.bsky.social at the 7th annual CCP Phenogenomics Conference! Dr Chen shows how rare disease foundations can really facilitate fantastic scientific progress directly helping patient families!
I still can't get over how cool cells can be reaching out and interacting with one another! This depth shaded membrane marker gives us an idea of how dynamic these extensions can be! #FluorescenceFriday 🔬🧪
Excited to share my latest paper from @stjuderesearch.bsky.social , where we leverage patient derived cortical organoids to study UBA5 associated neurodevelopmental disorders.
Its FINALLY here! The first #FluorescenceFriday 🧪🔬out of the Hall lab! We're still in the process of optimizing different fixatives to look for cytonemes and cellular extensions, but a fantastic first time imaging them from Morgan Hiebert!
NIH3T3 cells with a long cytoneme contacting one of the cells to deliver a signal. The SHH ligand is in magenta, the SHH transport protein DISP is in red. Nuclei are blue. Green is the adhesion protein BOC.
Despite all that is going on, I will not miss a #FluorescenceFriday! ✊ This is a confocal micrograph of a long cytoneme making contact with a recipient NIH3T3 cell (right) to deliver SHH ligand. The 🟣 dots are packages of SHH. Very cool! 🔬 by former postdoc @erichall.bsky.social. 🧪 #SciArt #DevBio
Here is an early #FluorescenceFriday post - a 3D render of a developing mouse neural tube showing a signaling filopodium (cytoneme) reaching toward a primary cilium (green) to deliver a cellular signal (SHH, magenta). See alt text for details. Research supported by #NIH #NIGMS 🔬 by Eric Hall. 🧪
🧪🧑🔬 We are actively recruiting graduate students in the lab right now at UM!
If you are, or know a student looking to do cool research involving cell signaling, development, and 🔬, please share with your networks. For more information, checkout the link below.
rfhs.myjboard.io/jobs/1054626...
Great lab! Great opportunity! Highly recommend!
The Mefford Lab is #hiring, come join us! @hcmefford.bsky.social
We have TWO positions open:
(1) *Lead Researcher/Scientist* who will have the opportunity to lead 2D and 3D #epilepsy #genetics modeling to inform better targeted treatments for kids. 🧠🧬💜
talent.stjude.org/careers/jobs...
