Glad that you enjoyed it, Manfred! 😉

Hallmarks of cancer—Then and now, and beyond Hanahan revisits the evolving framework of cancer hallmarks, synthesizing 25 years of conceptual refinement into a multidimensional view of tumor biology. This review highlights how aberrant capabilit...

Follow up to Doug Hanahan’s visionary article about the stages of cancer development from back in the 1990s

www.cell.com/cell/fulltex...

As 2025 ends, we sincerely thank you for your trust and support of EFMC.

Wishing you a joyful festive season and a prosperous New Year!

Warm regards,
Luc Van Hijfte (EFMC President)
Gianluca Sbardella (EFMC President Elect)

The #AvogadroColloquia 2025 ended in the best possible way, with an amazing, truly inspiring talk by @francesarnold.bsky.social. A great honor for the Italian chemical community (@socchimita.bsky.social and CNR) and an unforgettable memory for the attendees.

Join @youngscinet.bsky.social for "Under Pressure: A Mental Health Conversation for the Academic Community," a virtual workshop aimed at building resilience, support and creating a healthier future for yourself and academia.
October 10 - 1PM
🔗 us06web.zoom.us/webinar/regi...

👩‍🔬 Have you read our latest #MedChemBioConversation ?

Get to know Maria Letizia Barreca from University of Perugia, Italy.🔍
Dive into our monthly talks with specialists to explore the latest breakthroughs in drug discovery and pick up some valuable advice.

🔗https://buff.ly/63Jy5As

(I had to repost this since the BlueSky account named DPhG is not related to DPhG…)

The report of the FiMC, co-organized by the Med Chem Division of the @gdch.de, the #DPhG and the @scs-dmccb.bsky.social, has been just published in #ChemMedChem (@chemistryeurope.bsky.social)

chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Modified Nucleotides in Bifunctional Antisense Oligonucleotides: Exploring their Anticancer Potential bifunctional antisense oligonucleotide (BASO) modulates pre-mRNA splicing by using two functional domains: an antisense region that hybridizes with target sequences and a regulatory region that recru...

A new
#ChemMedChem (@chemistryeurope.bsky.social) article explores the effect of modified bifunctional antisense oligonucleotides (BASOs) on the phenotype of cancer cells, evaluated by real-time measurement of cell proliferation and motility. chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out (chemistry-europe.onlinelibrary.wiley.com/toc/18607187...) with a Front Cover illustrating the crystal structure of the N-terminal domain of clathrin with the known binding sites colored and a selection of Pitstop 2 analogues.

An Highlight article just accepted in #ChemMedChem (@chemistryeurope.bsky.social) spotlights #balinatunfib, an orally available small molecule jointly developed by Sanofi and UCB preventing TNFα from effectively binding to its receptors.

chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out (chemistry-europe.onlinelibrary.wiley.com/toc/18607187...)!

Social media and connecting with our community

I have poked the @rsc.org on X/Twitter a bit over the years (sorry folks...), but huge kudos to them for leaving what has become even more of a toxic and hateful platform www.rsc.org/news-events/... 👏 #chemsky

Only two weeks left to apply for a Flash Talk at the 5th Virtual @chembiotalks.bsky.social!

If you are a PhD or postdoc and want a chance to present to a global #ChemBio audience, make sure to check out our abstract challenge: chemistry-europe.onlinelibrary.wiley.com/hub/journal/...

Another great edition of @youngscinet.bsky.social #MedChemBioOnline is going to start in 1 hour and a half. Do not miss the opportunity to learn about "Best Practices in Discovering PROTACs" with experts in the field!

The last talk of the day at the 11th Novalix Conference “Biophysics in Drug Discovery” was the terrific keynote lecture by Stefan Knapp on "Comprehensive Characterization of Chemical Tools and New Modalities such as PROTACs".
@thesgc.bsky.social

Amazing keynote lecture by Amanda Garner at the 11th Novalix Conference—Biophysics in Drug Discovery in Strasbourg.

Amanda delivered a brilliant talk on "Enabling Technologies for Revealing Druggable Paths in RNA Biology".
@acsmedi.bsky.social

Great talk by @mariaduca-cnrs.bsky.social at the 11th Novalix Conference about Biophysics in Drug Discovery. Maria presented a few of her group projects, talking on how to target RNA using synthetic small molecules and how to discover an characterize RNA binders. Brilliant!

The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out!

chemistry-europe.onlinelibrary.wiley.com/toc/18607187...

No orders for supplies/reagents/equipment (already a huge bottleneck after earlier cuts). No travel or conference registrations. And certainly no hiring.

So this could be a total freeze, in everything but name. Is that the new workaround the administration is trying? Isn't that illegal? (2/2)

I'm getting word that the latest attempt to strangle what's left of the NIH is that purchasing agents have been mostly/completely cut, with the purchasing to be done by centralized GSA staff. Who either don't exist or aren't assigned.

That means in practice no spending at all! (1/2)

12 drug candidates debut in San Diego Structures unveiled during first-time disclosures symposium

If you love drug candidates but weren't able to attend the #FirstTimeDisclosures symposium at #ACSSpring2025, check out my story about the session for @cenmag.bsky.social - with lots of cool-looking molecules.
cen.acs.org/acs-news/acs...

Absolutely my pleasure! Looking forward to meeting you again in Rome in late November for the Avogadro Colloquia of the @socchimita.bsky.social

An amazing, totally inspirational and emotional journey! The @acs.org Priestley Medal talk by @francesarnold.bsky.social at #ACSSpring2025

The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out!

chemistry-europe.onlinelibrary.wiley.com/toc/18607187...

Come together, right now The chaos, conflicting information, firings, and hurtful rhetoric of the Trump administration’s approach to science over the past month are causing anxiety, grief, and concern for the scientific commu...

The response of the science community to the last month is not about one statement or action. It's about all of us with our different frames. For Science's part, we are doing what we have always done and have no plans to change. My thoughts on what we can do. www.science.org/doi/10.1126/...

Trump Tracker: Firings, lawsuits, and U.S. science in chaos Follow President Donald Trump’s impact on U.S. research and science globally

New on @science.org's daily Trump Tracker: A key influenza vaccine meeting gets abruptly canceled, and more than 90% of all USAID grants are terminated.
www.science.org/content/arti...

Trump credit card freeze sparks alarm at health agencies “Cost efficiency” order could block travel, supplies for labs and patient care

A new White House freeze on using government-issued credit cards is the latest shock for federal scientists, potentially affecting everything from conference travel to needed purchases for clinical care or lab work. scim.ag/4hV9oRb

A Career doing STUFF, a Guest Editorial by Mike Hann for the #ChemMedChem (@chemistryeurope.bsky.social) MedChem Musings series, summarises the many things he did during his 45 year-career in drug discovery. Practical advices and inspiration for future generations of researchers.

lnkd.in/dNNy7FaE

The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Hit to Lead Best practices for the Hit-to-Lead phase of drug discovery are exemplified in this article, with links to further materials and references as a learning resource. This consensus output was produced b....

The Hit to Lead process is an integral part of contemporary drug discovery.
A perspective just published in #ChemMedChem (@chemistryeurope.bsky.social), highlight the new set of @euromedchem.bsky.social best practices focused on H2L.
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...