A Streamlined High Performance Liquid Chromatography with Tandem Mass Spectrometry Based Workflow for Rapid Screening of Cellular Accumulation of Small Molecules This study uses six small-molecule inhibitors to evaluate optimal cellular accumulation assay conditions in a 96-well format with high performance liquid chromatography with tandem mass spectrometry ...

A Streamlined High Performance Liquid Chromatography with Tandem Mass Spectrometry Based Workflow for Rapid Screening of Cellular Accumulation of Small Molecules #ChemMedChem chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Profiling Inhibitor Scaffolds for the Cancer Target Jumonji‐C Domain‐Containing Protein 6 High-throughput mass spectrometry assays identify scaffolds for the development of inhibitors of the anticancer target Jumonji-C domain-containing protein 6 (JMJD6). Molecular docking studies suggest...

Profiling Inhibitor Scaffolds for the Cancer Target Jumonji‐C Domain‐Containing Protein 6 #ChemMedChem #MassSpec chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

#research

C1′-Branched Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum 6-Oxopurine Phosphoribosyltransferase
(Frydrych et al.) – #ChemMedChem: doi.org/10.1002/cmdc...

@iocbprague.bsky.social @czechacademy.bsky.social

The report of the FiMC, co-organized by the Med Chem Division of the @gdch.de, the #DPhG and the @scs-dmccb.bsky.social, has been just published in #ChemMedChem (@chemistryeurope.bsky.social)

chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Modified Nucleotides in Bifunctional Antisense Oligonucleotides: Exploring their Anticancer Potential bifunctional antisense oligonucleotide (BASO) modulates pre-mRNA splicing by using two functional domains: an antisense region that hybridizes with target sequences and a regulatory region that recru...

A new
#ChemMedChem (@chemistryeurope.bsky.social) article explores the effect of modified bifunctional antisense oligonucleotides (BASOs) on the phenotype of cancer cells, evaluated by real-time measurement of cell proliferation and motility. chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out (chemistry-europe.onlinelibrary.wiley.com/toc/18607187...) with a Front Cover illustrating the crystal structure of the N-terminal domain of clathrin with the known binding sites colored and a selection of Pitstop 2 analogues.

An Highlight article just accepted in #ChemMedChem (@chemistryeurope.bsky.social) spotlights #balinatunfib, an orally available small molecule jointly developed by Sanofi and UCB preventing TNFα from effectively binding to its receptors.

chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out (chemistry-europe.onlinelibrary.wiley.com/toc/18607187...)!

The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out!

chemistry-europe.onlinelibrary.wiley.com/toc/18607187...

It's really amazing to hold, for the first time, your own publication printed in a scientific journal in your hands. ✔️🧪 Thanks @chemistryeurope.bsky.social for making this possible! 🥳🧪

chemistry-europe.onlinelibrary.wiley.com/doi/full/10....

#chemmedchem #wiley #peptides #SARS-CoV-2 #ACE2

Polymeric nanoparticles encapsulating nickel, palladium & platinum bis(dithiolene) complexes as theranostic platforms for cancer therapy
Check out F Camerel et al #ISCR & collab. #IBMM #ChemMedChem paper👏
➡️ iscr.univ-rennes.fr/polymeric-na...
@rennesuniv.bsky.social @cnrs-bretagneloire.bsky.social

The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out!

chemistry-europe.onlinelibrary.wiley.com/toc/18607187...

Analogues of Natural Macarangin B Display Potent Antiviral Activity and Better Metabolic Stability Simplified analogues of macarangin B, a natural compound with potent OSBP-targeted antiviral activity against Zika virus were elaborated with the aim of enhancing metabolic stability. The most promis...

Check out our last article published in #ChemMedChem
@chemistryeurope.bsky.social about the synthesis of simplified analogs of antiviral macarangin B. Great work done by G. Jézéquel & J. Fargier @icsnlab.bsky.social @cnrs.fr @univparissaclay.bsky.social with #IPMC & #PIMIT.
👉 doi.org/10.1002/cmdc...

A Career doing STUFF, a Guest Editorial by Mike Hann for the #ChemMedChem (@chemistryeurope.bsky.social) MedChem Musings series, summarises the many things he did during his 45 year-career in drug discovery. Practical advices and inspiration for future generations of researchers.

lnkd.in/dNNy7FaE

The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Hit to Lead Best practices for the Hit-to-Lead phase of drug discovery are exemplified in this article, with links to further materials and references as a learning resource. This consensus output was produced b....

The Hit to Lead process is an integral part of contemporary drug discovery.
A perspective just published in #ChemMedChem (@chemistryeurope.bsky.social), highlight the new set of @euromedchem.bsky.social best practices focused on H2L.
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out!

chemistry-europe.onlinelibrary.wiley.com/toc/18607187...

Understanding of how structural elements impact #atropisomer stability enables the more efficient optimization of this important feature. A new manuscript just accepted in #ChemMedChem (@chemistryeurope.bsky.social)

chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

A β-glucuronidase-responsive albumin-binding prodrug programmed to release a potent Isocombretastatin A-4 analog within the tumor microenvironment.
Just accepted in #ChemMedChem @chemistryeurope.bsky.social

chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

A new methodology to derive biomolecular structure ensembles from distance distribution measurements via a library of tagged proteins bound to an unlabeled and otherwise unmodified target biologic.
Just accepted in #ChemMedChem (@chemistryeurope.bsky.social)

lnkd.in/eAiqfVWa

The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out!
chemistry-europe.onlinelibrary.wiley.com/toc/18607187...

Assessing protonation states for two separate systems (protein and ligand) might result in the incorrect assignment of protonation states and hence incorrect calculation of binding energy. Just accepted in #ChemMedChem (@chemistryeurope.bsky.social).
lnkd.in/ePCrpt8S

A review just accepted in #ChemMedChem (@chemistryeurope.bsky.social) highlights the application of deuteration strategy in drug design and summarize the progress in the field of deuterated drugs.

chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

In a manuscript just accepted in #ChemMedChem (@chemistryeurope.bsky.social), the authors (@novartis.bsky.social) present thiazole-based IL-17 inhibitors discovered through a scaffold-morphing strategy.

chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Happy Holiday Season from #ChemMedChem (@chemistryeurope.bsky.social). We want to thank all the authors and reviewers for all the contributions to CMC in this 2024. We hope you will have a great break, and wish you a fantastic 2025! And we also hope to receive a lot of manuscripts from you in 2025!

The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out (chemistry-europe.onlinelibrary.wiley.com/toc/18607187...), with a cover showing the encapsulation of Aβ peptides within reverse micelles, symbolizing the controlled aggregation of Aβ oligomers within these nano-sized environments.

The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out (chemistry-europe.onlinelibrary.wiley.com/toc/18607187...), with a Front Cover highligting a review on the development of conditional PROTACs to overcome the limitations of conventional PROTACs.

Highlights from the Lowlands: Early Career Researchers Shine at Medicinal Chemistry Frontiers 2024 The annual EFMC-ACS MEDI Medicinal Chemistry Frontiers was held in Utrecht in Spring 2024. Summarized here are some of the major themes from the event, including the enriching research contributions ...

Just published in #ChemMedChem (@chemistryeurope.bsky.social): Highlights from the Lowlands: Early Career Researchers Shine at Medicinal Chemistry Frontiers 2024 #MedChemFrontiers24

chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

How Should we Teach Medicinal Chemistry in Higher Education to Prepare Students for a Future Career as Medicinal Chemists and Drug Designers? – A Teacher's Perspective Paradigm changes in drug discovery and technology driven innovation have changed the field of medicinal chemistry in recent years – It is time to revise the way we teach medicinal chemistry in higher...

It is time to revise the way we teach medicinal chemistry in higher education to prepare students for a future career as medicinal chemists and drug designers! A #ChemMedChem (@chemistryeurope.bsky.social) perspective by @docklahn.bsky.social.
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

In a manuscript just accepted in #ChemMedChem (@chemistryeurope.bsky.social), the authors (from @novartis.bsky.social and @ethzurich.bsky.social) describe the identification of a candidate PET imaging agent for the NLRP3 protein.
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

In a review just accepted in #ChemMedChem (@chemistryeurope.bsky.social), the authors (from @astrazeneca.bsky.social) highlight recent advancements in the enzymatic functionalisation of amino acids to produce a variety of ncAAs.
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...