🧪 A team of organic chemists led by Paulo Paioti at @iocbprague.bsky.social developed a platform to produce drug-like #atropisomers with C–N restricted bonds. 1/7🧵

#chemistry #chemie #iocb #iocbprague #atropisomer #research #czechscience

#research #organicchemistry #atropisomer

Nucleophilic aromatic substitutions enable diversity-oriented synthesis of heterocyclic atropisomers via non-atropisomeric intermediates (Šimek et al.) – @natcomms.nature.com: doi.org/10.1038/s414...

@iocbprague.bsky.social @sciencecharles.bsky.social

Understanding of how structural elements impact #atropisomer stability enables the more efficient optimization of this important feature. A new manuscript just accepted in #ChemMedChem (@chemistryeurope.bsky.social)

chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...