Frontiers | Walking on the tightrope: the shared roles of the bridging pericytes in the brain The vasculature of the central nervous system (CNS) is a highly specialized structure that delivers oxygen and nutrients to energy-demanding neural cells whi...

🚨 Review Alert

*Walking on the tightrope: the shared roles of the bridging pericytes in the brain*

Congratulations Audrey Chagnot!! 🥳

Bias aside, this feels like a really meaningful piece for the cerebrovascular field! 😊

www.frontiersin.org/journals/cel...

Microglial cyclooxygenase-1 modulates cerebral capillary basal tone in vivo in mice - Nature Communications The role of myeloid cells in vascular regulation remains incompletely understood. Here, the authors show that microglia are the only myeloid cells that localize to capillaries and that they maintain b...

Microglial control of cerebral capillary basal tone. Congrats to @eyolab.bsky.social & team ! #cerebrovascular

Showing how a precapillary sphincter dilates during high blood pressure

🐭🧠 #PrecapillarySphincters (PS) at the #arteriole–#capillary junction rapidly dilate ~30% in seconds during #SensoryStimulation—regulating #capillary #BloodFlow dynamically. Here we investigated whether they protect downstream microvessels during abrupt #BloodPressure surges 🧪🧵

Microglia modulate the cerebrovascular reactivity through ectonucleotidase CD39 - Nature Communications Microglia and border-associated macrophages play a role in regulating cerebral blood flow (CBF), but the underlying mechanisms are unclear. Here, the authors show a role for microglial CD39 in the reg...

New study about the role of microglia in regulating #cerebrovascular function, with an interesting twist on purineric signaling doi.org/10.1038/s414...

Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus - Nature Neuroscience Microglia are proposed to have a role in brain development through synaptic engulfment and paracrine signaling. O’Keeffe et al. show that certain neurodevelopmental processes attributed to microglia c...

Mice lacking microglia (Csf1r∆FIRE/∆FIRE) have normal
-synapse number and maturation
-seizure susceptibility and hippocampal-prefrontal cortex coherence
-segregation of inputs into the lateral geniculate nucleus
-neuronal and astrocytic gene expression

www.nature.com/articles/s41...

Done :)

Had a fantastic week at #ANS2024 with Australasian Neuroscience colleagues talking #microglia, #pericytes and #TasmanianDevils. Look forward to seeing you all again in #Hobart for #ANS2025!

Done! :)

You're in :)

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We're not entirely sure but it may be related to marsupials living within a low oxygen environment in the pouch, or it might help for rapid post-natal development. Thanks for the interest!

A huge thank you to @wildimmunity.bsky.social nity.bsky.social, @gracerussell.bsky.social cerussell.bsky.social, @jakecashion.bsky.social and Brad Sutherland for this very unique collaboration! (2/2) Isolectin 🟢, PDGFRβ 💗, DAPI 🔵

Here's a fun one for #FluorescenceFriday. Did you know #marsupials have an entirely different CNS vascular anatomy to most animals? Arterioles and venules enter the brain and branch in unison, terminating at capillary loops. Check out this example from a #TasmanianDevil brain! (1/2)

Done! :)

Done :)

Here we show how #microglia contact #pericytes and #endothelialcells in the #venule end of the #capillary bed. Note also how a #primarycilium of an #interneuron invaginates the microglia. But why? 🤔 journals.sagepub.com/doi/full/10.... @gazz4science.bsky.social

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Added!

Added :)

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Lovely new review to help identify features of microglia in EM images!

Added!

Done :)

Calling all #pericyte researchers!

Here's a list of us to start a community on Bluesky. Please feel free to reply to get added and share with your colleagues as more join!

go.bsky.app/GhVdxzC

some great starter packs for the #glia, #astrocyte, #oligodendrocyte, #microglia, #neuro researcher: gliasky, astrocytesky, microglia
But if you also like interactions between celltypes, please help this starter pack get started. Maybe someone can connect all of us in a feed?

go.bsky.app/MHtJzeC

Yes please 🙋‍♂️☺️

Microglia community, let’s start the discussion 🧠 follow the Microglia Starter Pack and ask @mancusorenzo.bsky.social to add your colleagues as they join Bluesky 🦋

go.bsky.app/DT3Cp4A

Yes please 🙋‍♂️😀

Someone had to do it! I created a starter pack for #Alzheimer’s #dementia #ADRD researchers on Bluesky. Please let me know who I left out! Hoping more and more of us will join Bluesky

go.bsky.app/22DpUEy

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