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Posts by Hanh Vu

"The selfish ribosome" paper is now published in @plosbiology.org . Have a look! Many thanks to the editors and reviewers!
doi.org/10.1371/jour...

12 hours ago 55 30 1 2
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#erc | Johanna Joyce What should Europe do when demand for its most successful frontier research programme keeps rising? Restrict access, or invest in the excellence it has created? A new open letter, spearheaded by Sara...

What should Europe do when demand for #ERC funding keeps rising?
Restrict access or invest in excellence?

Please read our open letter calling for reconsideration of the ERC 2027 resubmission restrictions & for constructive alternatives that preserve openness

Consider to share & sign - see below 🧪

11 hours ago 32 30 2 3
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New Pre-Print Alert!

Evolving initial conditions: an alternative developmental route to morphological diversity

with Shannon Taylor and @jamesehammond.bsky.social

www.biorxiv.org/content/10.6...

1 day ago 123 48 6 2
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These images show live embryos of animals (jellyfish, crustacean, worm, sea urchin, sea squirt, beetle) and one of animals closest single-celled relatives. They were captured taking advantage of fluorescent proteins localised on the outer membrane of cells, allowing us to observe cell outlines. 1/9

3 days ago 185 53 4 5

Now published. Congrats to Soham and all co-authors! www.science.org/doi/10.1126/....
@embl.org

4 days ago 52 20 2 1

My first PhD student‘s, Kavan Gor, paper on 5-color single-molecule imaging of co-transcriptional RNA folding is out in @science.org Advances!

He finds how RNA modification enzymes, antisense oligonucleotides and ribosomal proteins re-route nascent RNA folding.

See more details in EMBL post below!

4 weeks ago 81 20 0 1

Woahhh!!! Congratulations James! Heidelberg University is so lucky to have you!

4 weeks ago 1 0 1 0

I'm thrilled to be starting as Professor for Molecular Biology at Heidelberg University in April. Looking forward to this adventure!

4 weeks ago 89 10 14 1
Evo-Devo-Tempo Lab

Very happy to announce that I will be joining the Faculty of Biology & @cibss.bsky.social at @uni-freiburg.de as an Emmy-Noether funded group leader.

We will tackle the molecular and genetic basis of developmental timing and size control using diverse Oryzias species. We are hiring at all levels !

4 weeks ago 69 15 16 3

Spectral multiplexing is typically limited to 4-5 channels. Our new preprint introduces a framework that utilizes DNA barcoding and signal tuning to enable robust spectral unmixing and ground-truth benchmarking to achieve 15-plex subcellular profiling without cycling
www.biorxiv.org/content/10.6...

1 month ago 79 27 2 0
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Quantitative biology community: QBMM is back! Line up is just stellar and many abstract selected talks. Apply! 👇

1 month ago 11 3 1 0

The time has come for another round of QBMM - we have a fantastic lineup of speakers in genomics, systems biology, and modeling cell dynamics. Check it out!

Co-orgs @elowitzlab.bsky.social @tinekelenstra.bsky.social @trayon.bsky.social @savitski-lab.bsky.social and I look forward to seeing you

1 month ago 15 6 0 2

🔥Exciting new paper from the Ikmi group @embl.org! The authors identified a set of mesoscale mechanical modules that can be used to predict species-specific shapes by combining a comparative analysis of cnidarian larval morphogenesis with active surface theory #morphogenesis #cnidaria

1 month ago 7 3 0 0

Our study on shape diversity in cnidarians is now published. The final version includes extensive new data that substantially extend the original bioRxiv preprint. Congrats to everyone who contributed to this work! www.cell.com/cell/fulltex...
@embl.org

1 month ago 140 64 5 3
Interallelic cis-regulatory dominance promotes robustness and evolutionary innovation Dominance is a central principle of genetics, yet the mechanistic basis and the evolutionary consequences of dominance arising from cis-regulatory variation remain poorly understood. We examined the evolutionary trajectories of a pleiotropic developmental enhancer in Drosophila . A genotype–phenotype map between D. melanogaster and D. simulans enhancer sequences reveals extensive epistasis, and many homozygous evolutionary paths reduce transcriptional output. In heterozygotes, however, regulatory dominance masks variants that reduce gene expression, potentially relaxing evolutionary constraints. Using allele-specific reporters and imaging, we show that this dominance arises from interallelic interactions (also known as transvection) reinforced by transcriptional hubs. Importantly, this enhancer dominance is cell-type specific, raising the possibility that it conceals deleterious effects in essential tissues while revealing novel, ectopic activity in others. Interallelic regulatory hubs may therefore expand the range of mutational paths available to diploid genomes while preserving essential transcriptional output. ### Competing Interest Statement The authors have declared no competing interest.

New Preprint! When one enhancer allele changes another's regulatory output, is that bad? We found it could be a feature — interallelic cis-regulatory dominance buffers outputs AND enables evolutionary innovation. Two for one!

Led by @ottilie.bsky.social from @embl.org

doi: doi.org/10.64898/202...

1 month ago 40 13 2 0

Excited to share my first preprint from my PhD w/ @justinmcrocker.bsky.social. We show that cell type-specific regulatory dominance promotes robustness and evolutionary innovation through interallelic transcriptional hubs, potentially expanding the mutational paths available to diploids. (1/18)

1 month ago 42 22 1 3
Home | Demirer Lab

We're hiring a postdoctoral researcher in plant genome engineering with expertise in synthetic biology, gene editing, and omics, with an interest in developing next-generation technologies for plants.🪴🧬

Available immediately. If interested, send your CV!

Feel free to share with your networks.

1 month ago 7 12 1 0
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It's out! Happy to present ITEC, a semi supervised algorithm with an extremely low error rate that can track cells in files of any size (think Terabytes!). We used it in many organisms, including zebrafish, to study how organs form and linked it to gene expression www.biorxiv.org/content/10.6... +🧪

1 month ago 198 59 20 3

I am very happy to share that I've started my new position @upcite.bsky.social and opened my lab @institutimagine.bsky.social 🎉

In the lab we will study how differences in X-linked gene dosage between the sexes affect fetal growth and survival and contribute to sex differences later in life 👩‍🔬🧪🧬🧫

1 month ago 49 11 13 0

1st McKinley Lab grad student’s 1st preprint!
@claireang.bsky.social studied how the uterus safely excises massive amounts of tissue during menstruation and pregnancy.

Come for her GORGEOUS images, stay for her incredible discoveries.
www.biorxiv.org/content/10.6...
w/ @akelleher1017.bsky.social

1 month ago 128 33 8 1
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That's it: #GfE2026 #GfESEBDDSDB2026 is over. Thanks for the science, talks, posters, chairing, discussions, helpers in back & front. See you latest at #GfE2028 for more #DevBio & oidsks for all the fish, plants, mice, worm, flies, frogs, squids, brown algae, human, -oids, whatnots and you.

1 month ago 31 15 1 5
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Lab Manager - Stuart Group The European Molecular Biology Laboratory (EMBL) is one of the world’s leading life science research organisations. With sites across Europe, EMBL fosters an international, collaborative, and inclusiv...

Are you fascinated by self-organised patterning processes?

The brand-new Stuart lab at EMBL Barcelona is looking for a lab manager!

Hannah @htstuart.bsky.social is a fantastic scientist and mentor. Building the lab with her will be a lot of fun!

embl.wd103.myworkdayjobs.com/EMBL/job/Bar...

1 month ago 20 13 0 0
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Gene regulatory networks: from correlative models to causal explanations Nature Reviews Genetics - In this Perspective, Maizels and Briscoe discuss the limitations of current models of gene regulatory networks and outline solutions to harness data abundance without...

New Perspective form Rory Maizels & me: "Gene regulatory networks: from correlative models to causal explanations"

Gene regulatory networks are supposed to give us mechanistic explanations of development, so why are we drowning in 'hairballs' of statistical correlations?

rdcu.be/e7zx7

1 month ago 121 46 2 2
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#WomanInScience

1 month ago 13 5 1 1
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Biological Laboratory | LEGO® Ideas This is a two-floor realistic Biological Laboratory building. In this design, I try to tell stories about biologists, introduce biology concepts to general publ…

I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗
beta.ideas.lego.com/product-idea...

6 months ago 222 131 8 12

Final version @nature.com of our paper describing unconventional multicellular development in a choanoflagellate inhabiting an extreme environment. A ton of new data since the first @biorxivpreprint.bsky.social preprint (which we've kept updating).

A brief 🧵 (carried over from the old place)

1 month ago 380 152 16 15
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@embl.org at its best: collaborative, open, transformative, and just the right amount of crazy. Dreaming of mechanistic cell biology *in the natural environment*? Dream no more, rent the AML.

www.biorxiv.org/content/10.6...

www.youtube.com/watch?v=jepb...

#WeFreezeOnTheBeach #ProtistsOnSky 🦠🌍🧪

1 month ago 87 31 3 2

Less than a week left for abstract submission for #EESMechanobiology - join us in this long-standing meeting on the mechanics of life.

1 month ago 9 12 0 0
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🤩to see this behemoth of a story out !
Pushed by @nikobiota.bsky.social & the Amazing @embl.org AML Team (Tina, Michael, Paulina) and in Co. with the Best #science #family you can dream of!

This truck was #home, for weeks in a row & in my heart for a lifetime.

www.biorxiv.org/content/10.6...

1 month ago 47 11 4 0
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Tissue phase transitions in development: more than just mechanics Summary: Tissue material phase transitions are classically thought to regulate tissue deformability. This Review emphasises their unexpected roles in directly influencing growth and patterning signall...

Excited to share our new review in @dev-journal.bsky.social on tissue phase transitions during development!

@karengrace12.bsky.social @nicolettapetridou.bsky.social

🔗 doi.org/10.1242/dev....

2 months ago 72 26 2 2