Cellular and molecular mechanisms of astrocyte plasticity in learning and memory Learning and memory arise from coordinated activity-dependent plasticity across neural circuits and brain regions. Astrocytes are increasingly recogni…

Really excited to share this review article written with @olsenlab-vt.bsky.social! We highlight that astrocytes exhibit the same activity-dependent plasticity mechanisms as neurons across learning and memory www.sciencedirect.com/science/arti...

Thrilled to wrap up the year and my postdoc work in the Nester lab with this publication 🥳! We show that astrocytic CREB regulates astrocyte calcium and D1-MSN activity to drive behavioral response to cocaine. pubmed.ncbi.nlm.nih.gov/41406210/

Lesion-remote astrocytes govern microglia-mediated white matter repair - Nature After spinal cord injury, lesion-remote astrocytes acquire heterogeneous, spatially restricted reactivity states that shape neuroinflammation, neural repair and neurological recovery.

Repair after CNS injury is not strictly local!

We find that lesion-remote #astrocytes (LRAs) exhibit striking spatiotemporal heterogeneity across spared regions of the injured spinal cord and shape neural repair far from the injury epicenter!

www.nature.com/articles/s41...

Really excited to announce that the Holt lab will be starting in January 2026 in the Center for Substance Use Research at Temple University Lewis Katz School of Medicine. Interested in the role of gene regulation, astrocytes, and addiction? I'm hiring at all positions-DM or email me! l-holt-lab.com

We characterized the NAc astrocyte transcriptome following cocaine self-administration and implicate astrocytic CREB as a cocaine-induced transcription factor in astrocytes that regulates astrocytic calcium, D1-MSN neuronal activity, and the behavioral response to cocaine

Excited to share the preprint for one of my postdoctoral projects in the Nestler lab 🥳