📣 Exciting news: my lab is moving to the Krembil Institute at the University of Toronto’s University Health Network in Fall 2026.
We’ll be recruiting for all roles, so reach out if you’re interesting in joining us to study spinal circuits for sensorimotor control
www.levine-lab.org
Congratulations Takashi!
I’m tenured! Thank you so much to everyone here, mentors, lab mates, colleagues, and the meiosis/centromere community for your support. This achievement was made possible by all the hard work by my amazing lab members over the past 6 years!🥳
New paper in Genes & Dev: we dissected how Sox2 — a key pluripotency TF — is regulated by a distal enhancer cluster (SCR) 100 kb away. The results challenge simple models of cohesin-mediated loop extrusion of gene regulation. genesdev.cshlp.org/content/earl... 🧵
Thrilled to present our comparative study on the evolution of zygotic genome activation (ZGA)!! 🥚🧬
Amazing PhD work of @campobes.bsky.social together with @fedemantica.bsky.social and many collaborators! @melisupf.bsky.social @crg.eu. Thread below 1/15
www.biorxiv.org/content/10.6...
We got the cover of @natneuro.nature.com April issue for Mukund's article!
Our study with @melnicklab on the discovery of a transient and tightly-regulated, plastic state of mature B cells during physiological immune response and potential links to aggressive lymphomas now out at NCB.👇Detailed threat by the amazing lead author @lscourzic.bsky.social!.
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🚨🚨 New preprint 🚨🚨
We found that the ovary directly controls protein appetite in Drosophila.
Yes — the ovary doesn’t just make eggs… it tells the fly what to eat!
www.biorxiv.org/content/10.6...
If you want all the details, click above ☝️
If you just want the fun, GIF-guided overview, keep reading 👇
🧵 CTCF is essential for embryonic development, but why has remained unclear. By combining gastruloids with a temporal degron system, we uncovered a surprising dual function — and it changes how we think about CTCF's role in development. 1/8 www.biorxiv.org/content/10.6...
🚨 Job Alert - Please share! 🙏
Interested in 3D gene regulation in development & evolution? 🤓🧬
💥 Our lab at @cabd-upo-csic.bsky.social is expanding!
We’re recruiting:
✅ PhD students
✅ Postdocs
💻🧪 Experimental or computational backgrounds welcome
👇 Details below
Flyer for symposium: https://ctrlepiedit.sciencesconf.org/
Very excited to announce the FIRST symposium on epigenome editing! These tools are becoming widely used in mol bio, ag & therapy. It's time to bring leaders together to discuss this rapidly growing and exciting field. And why not in Paris! Please register & share! (1/2) ctrlepiedit.sciencesconf.org
We are very proud to present our newest paper on the role of Wnt signalling in abscission dynamics in stem cells! A brief thread to entice you to read Snježana’s exciting foray into signalling.
Can we make brains “smarter”? By boosting mitochondrial metabolism in neurons of memory circuits, we improved memory in flies and mice. Thrilled to see this work out - congrats to @amrapalianjali.bsky.social for spectacular work, and to all lab members for invaluable contributions!
Come on join us! We are searching for the next technical associate to join our lab ~Summer 2026.
This could be a great position for someone who is graduating this spring and is looking for 2 more years of research experience before starting their PhD:
careers.peopleclick.com/careerscp/cl...
Delighted to share our new paper on LXR agonism pre-conditioning T cells to more readily adopt effector states, out in @jem.org today. This was a long project started in @sohailtavazoie.bsky.social's lab and completed across the atlantic here in Berlin at Charité.
New preprint from the lab! We dig into the regulatory roles of TEs in the mouse placenta, with some surprising findings. Led by the awesome @smamante.bsky.social. Particular kudos to him for navigating the many twists and turns of the project.
Preprint alert! 🥸
Yajie Zhu (PhD graduate) and Mariano Barbieri (postdoc, @spp2202.bsky.social Accelerator award) produced a package that will classify loops in your #3Dgenomics data based on (whichever) epigenomic data you have available. Keep reading...
1/n
www.biorxiv.org/content/10.6...
Preprint alert: Jiangyuan Liu developed a new workflow for chromatin loop calling across Hi-C datasets, e.g., during differentiation. Most loops are shared between datasets/cell states. Important work for all interested in chromatin loops and how to identify them!
www.biorxiv.org/content/10.6...
Our work on #RegulatoryTrajectories is out today in Nat. Comms: www.nature.com/articles/s41...
Led by @raquelrouco.bsky.social, this study establishes a new framework to study how enhancer landscapes act sequentially at developmental loci and are silenced to shape gene expression patterns. (1/n)
Our work on the evolution of the regulatory genome of echinoderms is now out in @natecoevo.nature.com. Led by my former PhD Marta Magri, Danila Voronov & Saoirse Foley. Great collaboration of Arnone, Hinman & Maeso labs, started long time ago with our missed José Luis Gomez-Skarmeta: rdcu.be/eXX8l
Read in Nature: nature.com/articles/s41586-025-09899-8
Stress controls epigenetic inheritance!
A histone ubiquitylation-based regulatory hub links stress/environmental signaling to heterochromatin self-propagation and epigenetic inheritance-reshaping how we think about development, drug resistance, and cancer
👉 nature.com/articles/s41586-025-09899-8
Glad to share our latest work that came out recently. We dive into the mechanisms of how Transcription Factors (TFs) like the nuclear receptor, ERα navigate the genome to find their targets.
🚨Seeking developmental or cell biologists🔬!🚨
Our department @ucl-cdb.bsky.social is looking to support scientists seeking to establish their lab with a fellowship. Deadline: 30 Jan. Apply here: www.ucl.ac.uk/work-at-ucl/...
Superstar
🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
We recently reported that promoter competition can contribute to the robust insulation of gene regulatory domains (www.nature.com/articles/s41...).
We now offer a 4-years PhD contract to investigate whether the dirsuption of this regulatory mechanism can lead to congenital defects. More details 👇
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
Having a lot of fun at #EMBOMobileGenome 😃
Perfect timing for our paper from the lab of @toddmacfarlan.bsky.social to be out @natcomms.nature.com!!
…and I’m currently on the job market looking for a new scientific home!
www.nature.com/articles/s41...
Really excited to see this out in the open: www.life-science-alliance.org/content/9/1/...! @isabellavoelkl.bsky.social explored and compared different in vitro developmental model systems to study ciliogenesis.
Spread the word! There is a professor position opening at our University @upcite.bsky.social. There are several possible (great) labs to join, but if you are interested in DNA methylation and epigenetics in mammals, don't hesitate to contact me directly!