Might antibiotics increase risks of aspergillosis?
Antibiotic-induced microbiota disruption impairs neutrophil-mediated immunity to respiratory Aspergillus fumigatus infection in mice
Mariano A. Aufiero & @fungalspore.bsky.social
mBio journals.asm.org/doi/10.1128/... #IDSky #MedMycoSky
Truffle hunting, line dancing, yodelling…
It’s early…
Go Hawks! - @josephsunlab.bsky.social
Yes I am!
Check out this terrific paper by George Chamilos and colleagues on the role of albumin in defense against mucormycosis. It was a treat to write the preview with Katrina Mar.
Brilliant statement
I’ve been very impressed with how @ameracadpeds.bsky.social has been fighting the horrific misinformation and science denialism peddled by RFK Jr & his minions
🎓 Huge congratulations to Kathleen Mills from the @fungalspore.bsky.social Hohl Lab on successfully defending her thesis: "Epithelial-Immune Cell Crosstalk Orchestrates Pulmonary Immunity to Aspergillus fumigatus" Her strong, dedicated presence in the program will truly be missed! 💫🧬
And a real doozy from the article:
"Most botanists from the mid-19th century viewed their study as a research backwater."
We're working hard here to change this long-held stereotype!
"You are my only friend in the debatable land of fungi”
Wonderful quote from by Mary Elizabeth Banning, a self-taught mycologist who described 23 new species of fungi in Maryland in the 19th century.
www.nytimes.com/2025/03/25/s...
#MicroSky #IDSky #ImmunoSky
So happy to see this story come together. Check it out! Kathleen Mills and many collaborators - GM-CSF–mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to Aspergillus fumigatus | Science Immunology www.science.org/doi/10.1126/...
Basel, Switzerland
Love the generations!!
A fantastic GRC on the Immunology of Fungal Infections. Gordon Brown, @slg1717.bsky.social, Bernie Hube, Mihai Netea, Ilse Jacobsen, Jay Vyas, Rob Wheeler, @lableibundgut.bsky.social - missing former/future 🪑 Luigina Romani, Rebecca Drummond, Bruce Klein, Neil Gow& George Deepe #MicroSky #ImmunoSky
@fungalspore.bsky.social and @lableibundgut.bsky.social look forward seeing you in Ventura Beach!
It's reasonable to give 5 mg/kg ambisone + posa up front since posa load takes time. I generally don't use prolonged (>2 weeks) dual therapy for mucormycosis. I don't use 10 mg/kg for mucormycosis due to toxicities. The key here is to get isolate and perform AST to optimize therapy quickly.
If Mucorales are in the picture, I do not think that posa and isavu are equivalent. Posa IMHO is a better drug than isavu. For aspergillosis, posa and vori are my top choices, isavu OK too. I only use isavu when patient cannot tolerate posa or vori.
Acute-angle branching is mot consistent with aspergillosis. Were septations present? I would treat with posaconazole which is enriched in CNS-penetrating neutrophils. For a very, very long time. Would try to culture tissue for isolate for ID.
My family knows me all too well. This well-chosen gift hits close to home. May your science (funding) prayers be answered in 2025! #IDSky #ImmunoSky #MedSky #MicroSky
Merry Christmas! Happy Hanukah! Blending 🇨🇭tradition with 🕯️+ 🎄(Catskills grown and cut on Dec. 24).
Terrific opportunity with wonderful colleagues!
A photo of Fred Hutch Cancer Center in Seattle, with the Arnold buildling and "the Vessel" sculpture in front.
Mount Rainer surrounded by a field of wildflowers
📢 Brand new ID faculty position just posted @fredhutch.bsky.social in Seattle. Join our ID group that studies infections in immunocompromised hosts. The Emerald city has great academics, phenomenal facilities, outstanding collaborators - all in amazing surroundings.
apply.interfolio.com/159913
No need to duplicate. You're much further along. Just grab from mine...
Starting an MSKCC starter pack to build community on @bsky.app #MedSky #ImmunoSky
Welcome aboard!
Would add @lableibundgut.bsky.social to the Mycology community.
