We usually think of #AlphaSynuclein in the brain, but this protein is found in blood, muscles, and even the gut. Studying it outside the brain may reveal how #ParkinsonsDisease and #LewyBody disorders spread, offering new clues to these diseases.
#Neuroscience #BrainHealth #Neurodegeneration
Protein Aggregation: Cause or Effect?
Are protein clumps the root cause of #NeurodegenerativeDiseases, or just a side effect?
Watch the full episode here:
linktr.ee/neuroscience...
#Neuroscience #BrainHealth #ProteinAggregation #ParkinsonsDisease #Neurodegeneration
Is Academia Truly Diverse? | Challenges in Academia with Dr. Sven Truckenbrodt
Dr. Sven Truckenbrodt explains why true diversity in science goes beyond cultural background to include different ways of thinking and collaborating.
🔗 Link to the video: youtu.be/V3t2lVIgm2E
Today on World Parkinson’s Day, we highlight a powerful truth: while genetics account for only about 15% of Parkinson’s Disease cases, the remaining 85% still have largely unknown causes.
Let’s raise awareness, support ongoing science, and stand with those affected.💙
#ParkinsonsDisease #Neuroscience
Complex diseases like #ParkinsonsDisease are often studied in fragments, with scientists focusing on small pieces of a much bigger problem. Stepping back to integrate these insights may be key to truly understanding the disease.
Watch the full episode here:
youtu.be/dFmhmOv75q0
Sleep Warning Sign
REM Sleep Behavior Disorder is one of the strongest early risk indicators for #Parkinson's disease, with up to 90% of patients developing Parkinson’s within a decade. Acting out vivid dreams may be an early sign long before diagnosis.
Full episode: youtu.be/dFmhmOv75q0
Exercise is the most effective disease-modifying strategy we currently have for Parkinson's disease, shown to reduce risk and slow progression.
Watch the full episode to learn how #Exercise can modify #ParkinsonsDisease risk and progression.
linktr.ee/neuroscience...
Innovation happens at the intersections. Dr. Sven Truckenbrodt discusses the interdisciplinary model at ISTA (Institute of Science and Technology Austria), where physicists, astronomers, and neuroscientists collaborate.
Check out the full episode here: youtu.be/a4qpFpjnOX4
Some scientific problems are too big for small labs, but too early for industry. 🧠 Dr. Sven Truckenbrodt explains Focused Research Organizations like E11 Bio, designed to scale #connectomics and reduce costs through team science.
youtube.com/shorts/o4yRb...
All imaging methods introduce artifacts. 🔬 In expansion microscopy, extracellular space may appear exaggerated. Dr. Sven Truckenbrodt discusses validation and limits in #brainimaging.
Check out our latest episode for more on #connectomics and #brainresearch.
linktr.ee/neuroscience...
Expansion microscopy physically enlarges tissue to bypass the diffraction limit. Dr. Sven Truckenbrodt explains how chemistry solves a physics problem in #neuroscience and #lightmicroscopy.
Check out the full episode here: youtu.be/a4qpFpjnOX4
Mapping the brain requires slicing tissue into thousands of sections and reconstructing it piece by piece. 🧠 Dr. Sven Truckenbrodt explains why data reconstruction is a major bottleneck in #connectomics.
Check out the full episode here: youtu.be/a4qpFpjnOX4
What does #connectomics actually give us? 🧠 It doesn’t explain behavior by itself but it provides the structural blueprint of neural circuits. Check out our latest episode for more on #connectomics and #brainresearch.
Check out the full episode here: youtu.be/a4qpFpjnOX4
How small is a synapse? At just nanometers scale, these tiny structures define brain connectivity. 🧠 Dr. Sven Truckenbrodt explains why synapse size matters for #neuroscience and #connectomics. Subscribe for more cutting-edge science!
Registration is open for #Neurizons2026 (19–22 May, Göttingen)!
Check the details & register: www.neurizons.uni-goettingen.de/neurizons-20...
Please share this conference information to help us reach more people.
🚨NEW EPISODE🚨
How do we map the #brain at molecular resolution?
@sventruckenbrodt.bsky.social Dr. Sven Truckenbrodt explains #connectomics, #expansion microscopy, neuronal barcoding, and why scaling brain mapping is still a major challenge.
🔗Link to the video: youtu.be/a4qpFpjnOX4
In our latest episode, Prof. Sauer explains how metabolic labelling introduces modified sugar precursors into cellular pathways, enabling fluorescent tagging of glycans and cell-surface structures for fluorescence imaging and quantitative analysis.
Watch the full episode here: youtu.be/8cXV9J5NJQQ
Prof. Markus Sauer discusses funding pressure, short-term contracts, and structural problems in academia, and how they shape scientific careers. #Academia #ResearchFunding
🔗 Link to the video: youtu.be/8EHLKFByvvw
In super-resolution microscopy, labelling is key: unnatural amino acids enable precise, site-specific fluorophore attachment. Watch the full episode to learn how advances in #microscopy are reshaping our understanding of cellular structure.
youtu.be/8cXV9J5NJQQ
#Antibodies are often too bulky to reach every target in dense clusters, leading to incomplete labeling. #expansionmicroscopy solves this by physically separating proteins, which facilitates efficient labeling and reveals protein complexes.
Watch the full episode here: youtu.be/8cXV9J5NJQQ
Seeing the presynapse at the nanometer scale with super-resolution microscopes.
Watch our latest episode to learn about how modern #microscopy reveals the inner architecture of cells here: youtu.be/8cXV9J5NJQQ
Prof. Markus Sauer @sauerlab.bsky.social explains the physical and chemical origins of #photobleaching; Repeated excitation drives #fluorescent dyes into reactive states where interactions with oxygen destroy their ability to emit light.
Watch the full episode here: youtu.be/8cXV9J5NJQQ
How can individual #molecules be imaged with nanometer precision? Prof. Sauer from @uni-wuerzburg.de explains the idea behind single-molecule localization microscopy, and how #superresolution changed #microscopy.
youtu.be/8cXV9J5NJQQ
#SuperResolution #SciencePodcast
🚨NEW EPISODE🚨
How do you see inside the cellular world with a nanometer precision? Watch our new episode with Prof. Markus Sauer @sauer-lab.bsky.social on super-resolution microscopy, dSTORM, and expansion microscopy.
🔗Link to the video: youtu.be/8cXV9J5NJQQ
Can exercise help prevent #ParkinsonsDisease? 🏃♂️ Prof. Randy Schekman explains how physical activity may support #brainhealth and resilience.
Watch the full episode here: youtu.be/G1FNf2LBPBo?...
Prof. Randy Schekman explains that Sergey Brin funds research without dictating how the money is spent, choosing instead to trust #scientists to manage #research decisions.
Watch the full episode here: youtu.be/G1FNf2LBPBo?...
How do billionaires support #science? Prof. Randy Schekman explains how private #funding has shaped large-scale #ParkinsonsDisease research efforts.
Watch the full episode here: youtu.be/G1FNf2LBPBo?...
What do we really know about #ParkinsonsDisease? Prof. Randy Schekman explains what science understands so far, and what remains unresolved.
Watch the full episode here: youtu.be/G1FNf2LBPBo?...
Why are extracellular vesicles so important? Prof. Randy Schekman explains that they carry key information about the cell’s internal state, with major implications for #diagnostics and #cellbiology.
Watch the full episode here: youtu.be/G1FNf2LBPBo?...
🚨NEW EPISODE🚨
Nobel Laureate Randy Schekman joins Neuroscience and Beyond to explore how cells transport information, why extracellular vesicles matter, and what science can -and cannot yet- do about Parkinson's.
Full episode is out now: youtu.be/G1FNf2LBPBo
