Are you the less lucky of the co-first or co-last authors? @shougroup.bsky.social makes the case for changes to the way that equal contribution information is sent to indexing sites such as #PubMed.
🧪 #AcademicSky #publishing
Rewiring an E3 #ligase enhances #cold resilience and #phosphate use in #maize
www.nature.com/articles/s41...
#PlantScience #PlantSci #SciComm @nature.com @natprot.nature.com @natplants.nature.com @planttreaty.bsky.social @plantoscope.bsky.social @plantevoeco.bsky.social @healthycrops.bsky.social
Fucking hell, that person needs an attitude change. The Nature paper part is very telling, impact but only the way they view it (overly traditional and terrible).
I wish I had more society impact on science. I am trying with how I run my lab.
Those amazing #phages 🦠 figured out 5mC chemistry before we did:
📄 Out today in @MolecularCell we describe a 5mC-selective #deaminase family in environmental phage genomes with broad applications for #5base #sequencing
#epigenetics #DNAmethylation #genomics #NGS 🧬🧪
www.cell.com/molecular-ce...
H3K27me3 and H2A.Z prime cold regulated genes, and their remodelling governs plant cold response www.biorxiv.org/content/10.64898/2026.04...
Another really good article published by @asimovpress.bsky.social (in 2024):
@matthewcobb.bsky.social's
"Francis Crick Was Misunderstood"
'The Central Dogma is not a "dogma," and it has never been broken.'
It's really a shame that Asimov Press is going on hiatus. I really liked their longform. 🧪
I suspect we only get so invested in whether the Central Dogma is broken or not because Crick called it that. If it had been "the principle of protein synthesis" or the "rules of transcription & translation" or something, it would seem less of a big deal. Remember, it's not a "dogma" at all.
Just a reminder that in computational biology and bioinformatics, we should NOT just translate the longest ORF in genomes but the most likely to be translated.
Our paper here details some of the pitfalls of you don’t. Be aware. Be warned.
doi.org/10.3390/gene...
Make sure to add this week's CCDM talk to your calendar 📆 If you're on #CurtinUni campus Friday 12pm, come hear from CCDM’s Johannes Debler as he explores Strange New Elements: Silenced genes and rogue DNA in fungal plant pathogens 🧬
"We find that while TAD boundaries pair more frequently than non-boundary regions, these interactions are infrequent and are uncorrelated with transcriptional activity of genes within the TAD"
elifesciences.org/articles/110...
Feels like this paper on protein-templated DNA synthesis by a natural enzyme warrants some comment.
So here's a 🧵. /1
www.science.org/doi/10.1126/...
I think it would be a bit of a stretch to put it that way. Drt3b is a kind of "machine for printing poly(AC)". It can only do that. It's hard to see how something like this could manage to write an arbitrary sequence, or even a more complex one, into DNA. /19
...disproof of the Central Dogma. But he said that it was very hard to see how sequence information, once it got to proteins, could "get back out again" and flow back to the nucleic acids. This work on Drt3b shows how that can happen. So is the Dogma actually wrong? /18
Something is evidently ensuring that after every A comes a C and vice versa. What is it? Well, it turns out that the peptide residues - the amino acids in the protein's chain - in the active site of the enzyme (where the polymerization happens) are doing that. /12
Fantastic new review article by @e-frangedakis.bsky.social on synbio of bryophytes.
Bryophytes are fascinating plants and their potential to advance synbio is huge. Please check it out:
pubs.acs.org/doi/10.1021/...
I am so excited to share our new findings with you! We provide the structural evidence for a direct protein-to-DNA information pathway, showing how a bacterial enzyme 'reads' its own structure to 'write' DNA. www.science.org/doi/10.1126/...
Excited to share our new findings in @science.org on how the DRT3 bacterial defense system uses a reverse transcriptase that builds DNA repeats without a nucleic acid template. Microbes never cease to amaze!
www.science.org/doi/10.1126/...
🌱 When a root cell undergoes symmetric division, are the daughter cells actually identical? By combining live-cell imaging and scRNAseq we discovered a new cell state with uneven BR activity. Read our full paper in Cell: doi.org/10.1016/j.ce... @nvukas.bsky.social @trevormnolan.bsky.social
I think too many papers have falsely claimed the death of the central dogma before, when it clearly did not contradict Crick’s outline but did the oversimplified version.
Plus, it only works for a very specific use-case. Not widely. Just to make biology even messier for teaching ❤️🤣
Modification of figure from Crick https://journals.plos.org/plosbiology/article/figure?id=10.1371/journal.pbio.2003243.g001
I think that the natural version of this will take a life time to scale. But there are nanopore technologies to reverse translate that I think will happen much sooner and really aid in proteomics.
I’m still upset I cannot get one in Australia or get some for my family in UK. As far as I can tell, this is the only freedom I miss from the USA. That and access to amazing burritos.
There are Science papers and then there are *I just dropped and shattered my mug of coffee Usual Suspects style* Science papers www.science.org/doi/10.1126/...
I might argue that this is more like a croissant suddenly leaking butter back out as a raw ingredient to make more. Very bizarre.
Certainly nothing like CRISPR, but counter acts years of expectations that a finished product could turn into the recipe again (or in this case, a part)
Today we mourn the passing of our beloved central dogma. It served Crick well. But it is time to let go. www.science.org/doi/10.1126/...
Well introns are my special interest and why we find TranSuite so useful. Once alternative splicing starts to happen, using the approve approach becomes very helpful. Potentially essential.
Haha I bet. We don’t get deep into those for plant genomes but I think they might be common in uORFs…which we current stay away from, but will be great to look at. But Ribo-seq data will likely be essential for that!
