Our latest work studying the reproducibility and sensitivity tradeoffs in spatial transcriptomics. All done with clinically sourced tissues as a foundation for future diagnostics - collab with @kelsmithpath.bsky.social : doi.org/10.1016/j.la...

Genetic and Iatrogenic Defects in Peripheral Tolerance Associated with Anti-Nephrin Antibody-Associated Minimal Change Disease Abstract. Introduction: Minimal change disease (MCD) is a common cause of nephrotic syndrome in children and adults. Immune dysregulation is a contributor, but the relative roles of individual compone...

We learn a lot from our patient's kidney biopsies. In collaboration with Astrid Weins (Brigham), we identified 2 patients with defects in peripheral immune tolerance (no Tregs, ICI tx for cancer). Both developed anti-nephrin antibody-associated minimal change disease: karger.com/gdz/article/...

A little mosaic project of my favorite cell 🐙

Oooh pretty!! Many thanks to @susanallison.bsky.social and the entire staff of @natrevneph.bsky.social for helping @oligopain.bsky.social and me with this review. LOVE ❤️ the cover!!

These starter packs are amazing. Thank you! 🫘🔬

Delighted to share our latest paper:

"The glomerular circadian clock temporally regulates basement membrane dynamics and the podocyte glucocorticoid response"

Expertly led by Rebecca Preston & in collaboration with clock superstar Qing Jun Meng

pubmed.ncbi.nlm.nih.gov/39515644/

Key findings 👇👇

Somewhere over the kidney rainbow... 🫘🌈 #NephSky #renalpath

Efficient and highly amplified imaging of nucleic acid targets in cellular and histopathological samples with pSABER - Nature Methods pSABER combines the power of signal amplification by exchange reaction (SABER) with the deposition of fluorescent or colorimetric substrates by horseradish peroxidase to enable enhanced signals for in...

The pSABER paper is now online!

pSABER is a new method for amplifying in situ hybridization signals

This work was driven by Sahar Attar and co-led by Ram Akliesh ([at] podocytes on the other app) with help from @shechnerlab.bsky.social @dschweppe.bsky.social

doi.org/10.1038/s415...

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