That's just one way lenacapavir can stop the virus. It's so effective as a therapeutic & prophylactic because it targets multiple stages of the HIV life cycle. Others have shown that it also stops the capsid from entering the nucleus, & disrupts assembly of new capsids.
Super cool to see @science.org named anti-HIV drug lenacapavir as Breakthrough of the Year. 🧪This breakthrough is underpinned by a wealth of basic research. Our contribution is to show how the drug cracks the protective HIV capsid 👇https://doi.org/10.7554/elife.83605
Thanks for pointing this out. New link: www.nature.com/articles/s41...
Hi Johannes, could you please add us?
Artistic depiction of the HIV capsid disguised as a host chaperone protein
The #HIV capsid mimics host chaperones to gain access into the nucleus, solving a long-standing mystery – David Jacques' team published in Nature.
@singmolsci.bsky.social #UNSWSBMS
🔗 nature.com/articles/s41...
🎨: Jon Berengut
We've still taking applications to join our team @singmolsci.bsky.social. Now closing 10Dec2023
🔗 external-careers.jobs.unsw.edu.au/cw/en/job/52...
🚨preprint @biorxivpreprint.bsky.social
We use #SingleMolecule🔬to see how a capsid-targeting antiviral (lenacapavir) hacks assembly of the HIV capsid, which normally protects the #HIV genome. Now also with real-time visualization of the drug breaking open the capsid. www.biorxiv.org/content/10.1...
Ariel photo of UNSW's main campus located near close to beaches
🚨Join us at UNSW Sydney!
We're searching for a postdoc to join our team to investigate dynamics of host-pathogen interactions🦠.
#SingleMolecule #microscopy🔬
Apply by 26Nov2023. Please share 🔗external-careers.jobs.unsw.edu.au/cw/en/job/520570/post-do...