London interdisciplinary #PhD position now open with myself, @sergemostowylab.bsky.social, & @gmknght.bsky.social on #phage -bacteria-host immune dynamics for WHO priority bacterial pathogens #Klebsiella, #Shigella, and #Staph. Combines cellular microbiology, genomics, & mathematical modelling.

Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
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Staggering analysis here linking ciprofloxacin resistance to specific mutations in #Klebsiella.

In short, using ONLY genotype, one can reasonably predict phenotypic CIP MICs! See Fig 3 (below).

Loving the splitting of MIC and disk diffusion data as well.

#AMR #MicroSky #IDSky

Thank you very much Mike!

Thanks Eva- especially for your insightful comments that made the paper much better!! :)

Ciprofloxacin resistance in Klebsiella pneumoniae: phenotype prediction from genotype and global distribution of resistance determinants BACKGROUND Ciprofloxacin resistant Klebsiella pneumoniae is common or emerging in many geographies, and knowledge of local resistance rates is important for empirical therapy. Whilst there are known K...

Come for the Klebs resistance data, stay for the DataViz! Massive congratulations to @karatsang.bsky.social on juggling such a huge meta-analysis; Ciprofloxacin resistance in Klebsiella pneumoniae: phenotype, genotype, global resistance patterns #MicroSky 💻🧬 www.biorxiv.org/content/10.1...

Excited to share the first beta release of AMRrules at #ABPHM! (Poster 42 tonight)
interpretamr.github.io/AMRrules

Complete genomes of 568 diverse Klebsiella pneumoniae species complex isolates from humans, animals, and marine sources in Norway from 2001 to 2020 | Microbiology Resource Announcements Klebsiella pneumoniae species complex are opportunistic pathogens that can transmit between humans, animals, and the environment (1). Here, we report hybrid genome assemblies of 578 (568 complete) gen...

Happy to share this resource of 568 closed Klebsiella pneumoniae species complex hybrid assemblies, including 1416 plasmids! ⭕️🦠

We hope this will be useful
- short reads, long reads, hybrid assembly or all combined - for your own tools/validations 🥳 #Microsky

journals.asm.org/doi/10.1128/...

We are pleased to launch the KlebNET Genomic Epidemiology Consortium!

We aim to build a public metadata repository; systematic risk framework for global genomic surveillance; and genomic epi reviews for high-impact #Klebsiella clones.

Join us here:
klebnet.org/klebnet-gsp-...

#ABPHM25