- Checkpoint signaling slows down replication in response to Top1 poisoning by camptothecin. - Checkpoint signaling is actively dampened by Slx4 and Fun30 to permit Exo1-dependent resection of replication forks. - Checkpoint dampening is critical to promote replication fork protection and preserve genome stability.

Today we are very pleased to share our latest article available now online @narjournal.bsky.social about the role of Slx4 scaffold and Fun30 (SMARCAD1 homolog) in DNA damage response regulation and replication fork protection against Top1-DNA crosslinks. academic.oup.com/nar/article/...

Indeed, congrats to Mathilde on the fantastic work she did with you, @benjaminpardo.bsky.social! We’re excited to have her and looking forward to all the great science ahead!!

Thank you to @doksanilab.bsky.social, @nitikataneja.bsky.social, and everyone who joined us for such a great discussion today!
We’re excited to invite you to our next webinar on March 3rd with @centromellone.bsky.social and Michele Pagano.

Please note that the zoom link for tomorrow's webinar with @nitikataneja.bsky.social and @doksanilab.bsky.social has been updated:
uzh.zoom.us/j/6466274666...

Congratulations, Karolin!!

Another great science appointment is coming up with
@nitikataneja.bsky.social and @doksanilab.bsky.social!
Join us live on Tuesday, February 3rd at 5pm (Rome) / 11am (NYC).
Zoom link: uniroma1.zoom.us/j/95149984403
Register here to stay in the loop: docs.google.com/forms/d/e/1F...

Thanks, Stefan!

Thanks, Karolin!

#ercpoc #erc #oncodeinstitute #cancerresearch #ovariancancer | Oncode Institute 🚨Great news: Oncode Investigators Nitika Taneja (Erasmus MC) and Sebastian Pomplun (LUMC) have been awarded European Research Council (ERC) Proof of Concept (PoC) funding. As European Commissioner E...

www.linkedin.com/posts/oncode...

https://amazingerasmusmc.com/biomedical/dna-test-who-benefits-from-chemotherapy-for-ovarian-cancer/

Delighted & grateful to receive @erc.europa.eu support once again! This ERC-PoC will translate fundamental insights into therapy-induced chromatin reorganization toward proof-of-concept in ovarian cancer patient samples. Special thanks to @oncodeinstitute.bsky.social for continued support! 🙌

Delighted to be part of this work from the Lopes lab identifying nucleoplasmic Lamin A/C as a key regulator of replication fork plasticity, acting via de novo heterochromatin and ADP-ribosylation to control RECQ1-mediated fork restart. Now in Nature Comm. 🎉Special efforts: @joannapaulson.bsky.social

Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with @raychaudhurilab.bsky.social

www.science.org/doi/10.1126/...

Halloween borrel at the department 🎃 : our PhDs & Postdocs showed next-level creativity by revealing the hidden monstrous sides of their PIs! 👻😂
Absolutely hilarious & scary indeed😜… though I’m starting to wonder if that’s really how they see me 👀😅

Ubiquitination of the histone variant mH2A1.2 prevents toxic RAD18 accumulation at a subset of genomic loci upon replication stress Using biochemical assays and a mutant disrupting RNF168-dependent ubiquitination of the histone variant macroH2A1.2, Galloy et al. identified an unexpected role for histone mH2A1.2 ubiquitination in p...

I am very excited to share the newest paper of the lab, a huge amount of work led by our talented PhD student Maxime Galloy, in close collaboration with Andréanne Blondeau, our dedicated research assistant for 10 years! 🙌

www.cell.com/molecular-ce...

Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels - preLights Lamin A/C maintains replication fork integrity during mild replication stress by modulating chromatin structure and restraining RECQ1 activity.

First preLights post from Jenny Singh (@jennysingh.bsky.social‬)

She covers work showing that Lamin A/C maintains replication fork integrity during mild replication stress by modulating chromatin structure & restraining RECQ1 activity. #preprint

#preLight ⬇️
prelights.biologists.com/highlights/n...

⏰🚨FINAL DEADLINE APPROACHING

#BGFP25 's extended reg deadline is closing on 02 June 2025. This is your last chance to register and confirm your place at this fantastic conference 🧬!

Join us in sunny Portugal this July and register now: bit.ly/3AnsVZF

Chilling after a wonderful Keystone meeting on ssDNA gaps…. Now filling the gaps with a peaceful mind!

#SouthKorea

A must for all DNA repair aficionados!

Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱
✔️ Confirmed top speakers
✔️ Ample opportunities for talks & posters

Don’t miss it: dnarepairmeeting-egmond2026.com

Abortion bans kill women

Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇

It’s beautiful, I think!! 😜

Join us in Lisbon this July to learn how cells "Balance Genome Fidelity & Plasticity". deadline for talks extended and a # of fellowships are available to offset trainee registration. www.fusion-conferences.com/conference/1...

Happy to have contributed(along with PhD students @joannapaulson.bsky.social & Collin Bakker) to such great work from @lopeslab.bsky.social and team!
www.biorxiv.org/content/10.1...

Online today @science.org 👀Molecular basis of FIGNL1 in dissociating RAD51 from #DNA and #chromatin by @alexcarver.bsky.social @layates.bsky.social et al. in @imperialcollegeldn.bsky.social @mskcancercenter.bsky.social
www.science.org/doi/10.1126/...

What are your plans for October 2025? It would be a fantastic time to visit Norway for the Endogenous DNA Damage and Repair conference with a stellar set of speaker covering a wide range of topics. www.endodnadamage.com

Congratulations, Ralph!!🥂

Dear all, my first post! I have postdoc positions available if you would like to join my lab in beautiful Sussex by the Sea! Please contact me on k.w.caldecott@sussex.ac.uk

behold our paper on Medusavirus nucleosomes. Fantastic work by Chelsea Toner, @nhoitsma.bsky.social, and Sashi Weerawarana This giant virus also encodes a linker histone, more about that in the paper 🧪👩‍🔬 🧵.
www.nature.com/articles/s41...

Congratulations!!👏

Happy to share our new paper with Goran Kokic and the Svejstrup lab in Cell!

We show that STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair.

Great teamwork by Diana, Marta and Paula!

www.cell.com/cell/fulltex...