preLights

@prelights.bsky.social

5 days ago

Classical enhancers couple cis-regulatory logic with transcriptional condensates and 3D genome architecture - preLights Inside super-enhancers, a few classical enhancers do the real work

Inside super-enhancers, a few classical enhancers do the real work 💪

Siddharth Singh covers a recent #preprint proposing a hierarchy inside super-enhancers; from the group of Biswajyoti Sahu #UofHelsinki #UofOslo

#preLight ⬇️👀
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preLights

@prelights.bsky.social

3 weeks ago

Cell-intrinsic compliance mechanism enables release of tensile stress to prevent tissue rupture - preLights The soft and flowing will prevail: fly extraembryonic tissue actively softens to keep the embryo from tearing itself apart.

The soft and flowing will prevail: fly extraembryonic tissue actively softens to keep the embryo from tearing itself apart. 🪰

Another insightful post by Ruoheng Li on work from Yu-Chiun Wang (yuchiunwang.bsky.social) & team #preprint #DevBio

#preLight ⬇️

prelights.biologists.com/highlights/c...

preLights

@prelights.bsky.social

1 month ago

Cooperation between cortical and cytoplasmic forces shapes planar 4-cell stage embryos - preLights How to make a 4-cell square ascidian embryo? Cytoplasmic pulling rotates centrosomes, cortical forces lock the plane.

How to make a 4-cell square ascidian embryo? Cytoplasmic pulling rotates centrosomes, cortical forces lock the plane.

Corentin Mollier & Shivani Dharmadhikari highlight a #preprint from Silvia Caballero-Mancebo & team @rdumollard.bsky.social

#preLight ⬇️
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preLights

@prelights.bsky.social

1 month ago

A drought stress-induced MYB transcription factor regulates pavement cell shape in leaves of European aspen (Populus tremula) - preLights Leaf pavement cells look deceptively simple, yet their shapes encode developmental history and environmental response. A MYB transcription factor contributes to fine-tuning this process in aspen.

Leaf pavement cells may look simple, yet their shapes encode developmental history & environmental response.

@srobertgroup.bsky.social show that a MYB transcription factor contributes to fine-tuning this process in aspen. #preprint

#preLight by Jeny Jose ⬇️
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preLights

@prelights.bsky.social

1 month ago

Cross Sectional and Longitudinal Imaging Reveals Spatiotemporal Divergence in Morphogenesis and Cell Lineage Specification between in-vivo and in-vitro Mouse Embryo during Pre- and Peri-implantation -... Environment is vital: development of in vitro mouse embryos lag behind their in vivo counterparts

Environment is vital: #development of in vitro mouse embryos lag behind their in vivo counterparts 🐁

New post from Heather Pollington on a recent #preprint from Huanhuan Yang. Includes an insightful discussion with the author.

#preLight ⬇️
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preLights

@prelights.bsky.social

1 month ago

Resilience to cardiac aging in Greenland shark Somniosus microcephalus - preLights Greenland sharks and the Quest for cardiac immortality! The authors of this study characterize the aging profile of the Greenland shark (Somniosus microcephalus), to evaluate their resilience to cardi...

Greenland sharks & the Quest for cardiac immortality ❤️ 🦈

Theodora Stougiannou highlights fascinating new work from Elena Chiavacci & colleagues studying a shark living in the abyss where temperatures are around 2°C! #preprint

#preLight ⬇️
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preLights

@prelights.bsky.social

1 month ago

PPARδ activation in microglia drives a transcriptional response that primes phagocytic function while countering inflammatory activation - preLights PPAR excellence: microglial transcription factor shows potential as a therapeutic target for Alzheimer’s disease

PPAR excellence: microglial transcription factor shows potential as a therapeutic target for Alzheimer’s disease. #neuroscience 🧠

Isabel Paine highlights work from Jacob S. Deyell & colleagues #preprint

#preLight ⬇️
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preLights

@prelights.bsky.social

1 month ago

Cannibalism as a mechanism to offset reproductive costs in three-spined sticklebacks - preLights Trying to understand why stickleback males cannibalize their offspring

Trying to understand why stickleback males cannibalize their offspring 🫣🐟

Tina Nguyen highlights a study delving “deep into understanding the complexity of this phenomenon and why it might be advantageous”. #preprint #ecology

#preLight ⬇️👀
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preLights

@prelights.bsky.social

1 month ago

The lipidomic architecture of the mouse brain - preLights Lipids get the space they deserve: Fusar Bassini et al. pioneer a MALDI-MS imaging and computational analysis, bring membrane lipids and their spatial organization to the spotlight and provide evidenc...

At the Centre for Regenerative Medicine #UoE, ECRs discuss preprints + now publish their discussions on #preLights!

First #preprint they highlight brings membrane lipids & their spatial organization to the spotlight. @epfl-brainmind.bsky.social

#preLight ⬇️
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preLights

@prelights.bsky.social

1 month ago

Neurons contain “hotspots” for mitochondrial biogenesis at distal branch points. #preprint

First #preLight posted by Lorena Olifiers - take a look! ⬇️👀

preLights

@prelights.bsky.social

2 months ago

Tissue mechanics and systemic signaling safeguard epithelial tissue against spindle misorientation - preLights The threefold way an epithelium copes with cell misplacement: pulling them up, killing them less, and removing the unwanted.

The threefold way an epithelium copes with cell misplacement: pulling them up, killing them less, and removing the unwanted.

Ruoheng Li discusses a #preprint from @florisbosveld.bsky.social & colleagues @ybellaichelab.bsky.social

Check out the #preLight ⬇️👀
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preLights

@prelights.bsky.social

2 months ago

Active flows drive clustering and sorting of membrane components with differential affinity to dynamic actin cytoskeleton - preLights The cell cortex behaves like a sorting hat: it groups membrane proteins by how tightly they bind to dynamic actin.

The cell cortex behaves like a sorting hat: it groups membrane proteins by how tightly they bind to dynamic actin. 🪄🎩

Insightful post from Teodora Piskova covering recent work of the #MayorLab & team @ncbsbangalore.bsky.social #CellBio #preprint

#preLight ⬇️
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DMM Journal

@dmmjournal.bsky.social

2 months ago

Check out this new #preLight post on the influence of macrophages on human #kidney organoids! With a bonus response from the authors of the #preprint

preLights

@prelights.bsky.social

2 months ago

Kanishka Parashar #UNIL has uploaded a #postLight. 👀

Here, Kanishka revisits work from @matteoall.bsky.social & team originally posted as a #preprint, highlighted as a #preLight and now published in @jcellsci.bsky.social

#postLight ⬇️👀
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preLights

@prelights.bsky.social

2 months ago

Human pluripotent stem cell-derived macrophages modify development of human kidney organoids - preLights Immune cells for nephron development; tweaking the organoid recipe! In the preprint highlighted here, the authors use human PSC-derived organoids to evaluate the contribution of macrophages to kidney ...

Immune cells for nephron development; tweaking the organoid recipe!

Theodora mixes science writing & visuals to highlight recent work from Filipa Lopes, Susan Kimber & team #FBMH_UoM #preprint #DevBio

Check out the #preLight + author response ⬇️👀
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preLights

@prelights.bsky.social

2 months ago

Trade-offs between surviving and thriving: A careful balance of physiological limitations and reproductive effort under thermal stress - preLights "I would risk over-heating just to be with you" - Male red-sided garter snake

"I would risk over-heating just to be with you" - Male red-sided garter snake🔥🐍

Tshepiso Majelantle highlights recent work on thermoregulatory behaviour. #preprint #zoology

Includes an insightful response from @drhubert.bsky.social #OregonState

#preLight ⬇️
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preLights

@prelights.bsky.social

2 months ago

KANK2 at focal adhesion regulates their maintenance and dynamics, while at fibrillar adhesions it influences cell migration via microtubule-dependent mechanism - preLights KANK2 plays a dual role – dictating cells when to move and when to stick!

KANK2 plays a dual role – dictating cells when to move and when to stick!

@vibhasingh.bsky.social covers recent work from Nikolina Stojanović & colleagues – includes a lovely discussion with the author team.

#preLight ⬇️
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preLights

@prelights.bsky.social

2 months ago

Cryo-EM reveals multiple mechanisms of ribosome inhibition by doxycycline - preLights Unconventional mechanisms of antibiotic action: Stacking and disorganizing

Unconventional mechanisms of antibiotic action: Stacking and disorganizing. #biochemistry

Leonie Brüne talks to William Stuart & Nicholas J. Harmer #UoEBiosciences about their recent #preprint

Check out the #preLight + insightful discussion ⬇️
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preLights

@prelights.bsky.social

2 months ago

Junctional Heterogeneity Shapes Epithelial Morphospace - preLights From uniform beginnings, junctional heterogeneity and cell-specific mechanics choreograph the stunning diversity of sensory epithelia.

From uniform beginnings, junctional heterogeneity and cell-specific mechanics choreograph the stunning diversity of sensory epithelia.

Bhaval Parmar discusses recent work from Anubhav Prakash @prakash-patterns.bsky.social & colleagues. #DevBio

#preLight ⬇️
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preLights

@prelights.bsky.social

2 months ago

PIP5K-Ras bistability triggers plasma membrane symmetry breaking to define cellular polarity and regulate migration - preLights One circuit to break them all: mutual inhibition of Ras–PIP5K circuit sparks polarity and migration.

And one that covers a #preprint from the group of Peter Devreotes on plasma membrane symmetry breaking.

#preLight ⬇️
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preLights

@prelights.bsky.social

2 months ago

Taxane-Induced Conformational Changes in the Microtubule Lattice Activate GEF-H1-Dependent RhoA Signaling - preLights More than just a stabilizer: Taxanes (cancer drugs) trigger the GEF-H1 – RhoA axis.

Two more recent preLights were written by Vibha Singh @vibhasingh.bsky.social 🙌

One that discusses Taxane-induced conformational changes in the microtubule lattice. #preprint from Joyce Meiring @joycemeiri.bsky.social and colleagues #UniUtrecht.

#preLight ⬇️
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preLights

@prelights.bsky.social

2 months ago

Enzymatic bromination of native peptides for late-stage structural diversification via Suzuki-Miyaura coupling - preLights Ready, set, brominate: RebH and engineered variant for bromination of peptidyl-Trp residues

Some excellent preLights to end 2025 🎆

The latest was written by Zhang-He Goh @goh-zhanghe.bsky.social, discussing an enzymatic method for tryptophan-specific bromination described in a recent #preprint from the lab of @amyweeks.bsky.social.

#preLight ⬇️
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preLights

@prelights.bsky.social

3 months ago

Mitochondrial Fatty Acid Oxidation is Stimulated by Red Light Irradiation - preLights Different wavelengths of sunlight can modulate the viability of keratinocytes (Skin cells), and the metabolism. Red light, particularly, affects oxygen consumption during three days post-irradiation a...

Check out the latest #preLight from the #preprint review initiative led by Marcus Oliveira #UFRJ #Brazil

⚡Characterising wavelength-selective regulation of keratinocyte metabolism from @aliciakowaltowski.bsky.social & team.

#preLight by Rickson Ribeiro ⬇️👀

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preLights

@prelights.bsky.social

3 months ago

Loss of MGST1 during fibroblast differentiation enhances vulnerability to oxidative stress in human heart failure - preLights The failing heart hides a biochemical vulnerability. MGST1, an antioxidant, down in fibroblasts means a ferroptosis-prone, oxidation-sensitive state. A new therapeutic angle surfaces.

The failing heart hides a biochemical vulnerability ❤️‍🩹

Jeny Jose: By linking MGST1 loss to fibroblast activation, ROS accumulation, & ferroptosis susceptibility, this #preprint provides a new perspective on heart failure progression.

#preLight ⬇️
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preLights

@prelights.bsky.social

3 months ago

Imaging cellular activity simultaneously across all organs of a vertebrate reveals body-wide circuits - preLights WHOLISTIC: A whole-body functional atlas of cellular dynamics

WHOLISTIC: A whole-body functional atlas of cellular dynamics

@sinanmalik.bsky.social covers work from the @mishaahrens.bsky.social Lab.

“This #preprint represents the kind of transformative science that redefines what is possible in a field.”

#preLight ⬇️
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preLights

@prelights.bsky.social

3 months ago

Microbial Feast or Famine: dietary carbohydrate composition and gut microbiota metabolic function - preLights Fibre for the win: Dietary influences on the gut microbiota

Fibre for the win: Dietary influences on the gut microbiota 🦠

Jasmine Talevi covers recent work from Blake Dirks & colleagues describing the microbial functional response to two very different diets. #preprint #microbiome

#preLight ⬇️ 👀
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preLights

@prelights.bsky.social

3 months ago

Vitamin B12 supports skeletal muscle oxidative phosphorylation capacity in male mice - preLights Vitamin B12 preserves skeletal muscle mitochondrial DNA integrity and respiration, linking B12 deficiency to mtDNA uracil accumulation and impaired muscle energy metabolism.

Vitamin B12 preserves skeletal muscle mitochondrial DNA integrity and respiration, linking B12 deficiency to mtDNA uracil accumulation and impaired muscle energy metabolism. #preprint from @marthafield.bsky.social & team

#preLight by Yan Aveiro dos Reis ⬇️👀
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preLights

@prelights.bsky.social

3 months ago

Scalable transcription factor mapping uncovers the regulatory dynamics of natural and synthetic transcription factors in human T cell states - preLights Meet TFlex— a new tool to uncover how natural and synthetic transcription factors shape human CD8+ T cell states.

Meet TFlex— a new tool to uncover how natural & synthetic transcription factors shape human CD8+ T cell states. #Immunology

Inês Caiado highlights recent work from Riley Mullins & colleagues. #preprint

#preLight ⬇️ 👀
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preLights

@prelights.bsky.social

3 months ago

Dosage-sensitive RBFOX2 autoregulation promotes cardiomyocyte differentiation by maturing the transcriptome - preLights A cardiomyocyte's journey to maturity: In the preprint highlighted here, the authors generate a model of RBFOX2 haploinsufficiency to identify the gene’s effects on cardiomyocyte maturation.

A cardiomyocyte's journey to maturity ❤️

The #preprint authors, Mengmeng Huang & team #BurnsLab, generate a model of RBFOX2 haploinsufficiency to identify the gene’s effects on cardiomyocyte maturation.

A more visual #preLight by Theodora Stougiannou ⬇️ 👀
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preLights

@prelights.bsky.social

3 months ago

A high-coverage genome from a 200,000-year-old Denisovan; A global map for introgressed structural variation and selection in humans - preLights Ancient Denisovan DNA from a 200,000-year-old genome and a new global map of archaic structural variants show that inherited Denisovan segments, including whole centromeres, still shape human diversit...

Ancient Denisovan DNA from a 200,000-year-old genome + a new global map of archaic structural variants show that inherited Denisovan segments, including whole centromeres, still shape human diversity and local adaptation today.

#preLight by Siddharth Singh ⬇️ prelights.biologists.com/highlights/a...