A brain-penetrant P2X7R antagonist mitigates Alzheimer’s disease pathology www.biorxiv.org/content/10.64898/2026.04.06.716621v1 #cryoem

Excited to share our latest preprint on bioRxiv!

www.biorxiv.org/content/10.6...

An international, multidisciplinary collaboration spanning structural biology, chemical biology, neuroscience, and translational medicine.

Grateful to everyone involved in making this work possible!

Molecular Structures of the Hearing Loss Associated Human P2X2 Receptor ATP is best known as the “fuel of the cell,” providing energy for nearly every biological process. But when ATP is released from cells, it takes on a very different role — acting as a danger signal th...

link.growkudos.com/1eub610y1hc

A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor pubmed.ncbi.nlm.nih.gov/40954149/ #cryoEM

Thank you, Steve!

Another manuscript from our group this week with the first structures of the human P2X7 receptor facilitating development of a novel scaffold for P2X7R antagonists:

urldefense.com/v3/__https:/...

@pacificnwcryoem.bsky.social
@ohsunews.bsky.social
@ohsubrain.bsky.social

Subtype-specific structural features of the hearing loss-associated human P2X2 receptor pubmed.ncbi.nlm.nih.gov/40938707/ #cryoEM

Our latest work on the human P2X2 receptor. We identified an alternate desensitized state conformation that provides insight into how ATP enters and/or leaves the pocket.

www.pnas.org/doi/10.1073/...

@pacificnwcryoem.bsky.social
@ohsunews.bsky.social
@ohsubrain.bsky.social

A true Physician-Scientist and @OHSUSOM #MDPhD alum, Dr. Steve Mansoor, sharing details about how his lab uses #DrugDesign principles to fit the ligand into the target receptor like a jigsaw piece. 🧩Thank you for your presentation Dr. Mansoor! @OHSUNews @OHSUCardio @OHSUSOM

The KCVI research retreat was a great success this year.

Very happy to participate. Looking forward to making this an annual event!

March 27, 2025: Adam Oken, Oregon Health and Sciences University YouTube video by CryoEM Service Centers

Adam Oken from our lab gave a great presentation summarizing some of the work we have been doing.

If you are interested, please watch a recording of his seminar, linked here:

youtu.be/IdcoLJc7X8M

The Changemakers: Steven E. Mansoor, M.D., Ph.D. | OHSU Foundation Cardiologist and physician-scientist Steven Mansoor, M.D., Ph.D., is researching new drugs to fight a variety of medical conditions.

Navigating the worlds of research and patient care requires both precision and passion, and @ohsunews.bsky.social's Dr. Steven E. Mansoor finds fulfillment in this work as a physician-scientist. ohsufoundation.org/stories/the-...

A paper from our group published a couple of months ago.

I am fortunate to have such a fantastic collaboration with amazing scientists from around the world.