Obesity-induced inflammation: connecting the periphery to the brain - Nature Metabolism Le Thuc and García-Cáceres discuss the effect of obesity-induced systemic inflammation on the brain, including hypothalamic circuits for whole-body energy homeostasis as well as cognitive function.

#Throwback 🧪

REVIEW | Obesity-induced inflammation: connecting the periphery to the brain

O Le Thuc & C García-Cáceres

Obesity as a catalyst for neurodegeneration - Nature Metabolism In this Perspective, mechanisms by which overnutrition and obesity contribute to neurodegeneration are discussed.

PERSPECTIVE | B Chen, A Rodríguez-Díaz, M Schneeberger, @erictopol.bsky.social

@ucsdmedschool.bsky.social; Yale Uni, US; @scripps.edu

Discussing mechanisms by which overnutrition and obesity contribute to neurodegeneration 🧪

Gut microbiota-derived indole-3-lactic acid suppresses anti-PD-1 efficacy in esophageal squamous cell carcinoma Zhou et al. reveal that gut L. salivarius and its metabolite indole-3-lactic acid (ILA) drive anti-PD-1 resistance in ESCC. Mechanistically, ILA activates AhR to suppress NF-κB signaling, triggering t...

#NatMicroPicks

Microbial factor in cancer immunotherapy resistance 🦀🦠💉

Ligilactobacillus salivarius–derived indole-3-lactic acid suppresses anti-tumor T‑cell populations, driving resistance to anti‑PD‑1 therapy in ESCC

#MicroSky #CancerSky #MicrobiomeSky

www.cell.com/cell-host-mi...

Harmonizing human plasma metabolite annotation with Plasma Benchmark - Nature Metabolism

#Throwback 🧪

CORRESPONDENCE | Harmonizing human plasma metabolite annotation with Plasma Benchmark
K Hanhineva et al.

Horizon Scanning Working Group genome engineering workshop | National Mouse Genetics Network On the 26th and 27th of November, the Network’s Horizon Scanning Working Group held its second workshop designed to build a UK community around the latest advances in genome engineering technologies. ...

Back in November, our Horizon Scanning Working Group held its second workshop designed to build a UK community around the latest advances in genome engineering technologies:
nmgn.mrc.ukri.org/news/horizon...

Great collaboration that took us to places we definitely were not anticipating! Thank you Zoe and congratulations to you too! 🎉 ♥️

Excited about the 2026 Prague Metabolism & Signaling Symposium in Prague, Czechia, bringing together leading scientists to explore cutting-edge research in metabolism, signaling, aging, cancer, immune responses & more! 🧬🔬
📅 June 24–27, 2026

More details at 👉 praguemetabolismsymposium.com

Saving The Life We Cannot See | NOEMA Conservation has traditionally ignored the planet’s smallest life forms. Microbiologists are trying to change that — before it’s too late.

We have Red Lists for mammals, birds and trees.

But until now, nothing for microbes

Noema Magazine explores our IUCN Microbial Conservation Specialist Group

The life we cannot see may be the most important life of all.

www.noemamag.com/saving-the-l...

Feeding gut microbes to nourish the brain: unravelling the diet–microbiota–gut–brain axis - Nature Metabolism This Review provides an overview of the interplay between host diet and the gut microbiota, and how this affects brain function.

#Throwback 🧪

REVIEW | Feeding gut microbes to nourish the brain: unravelling the diet–microbiota–gut–brain axis

@elizschneider.bsky.social‬, ‪@jfcryan.bsky.social et al

Gut bacteria ammonia production restores acetylcholine neurotransmission and bowel motility Nature Microbiology, Published online: 26 February 2026; doi:10.1038/s41564-026-02292-9Acetylcholine levels are reduced in gut dysmotility conditions. We find that gut acetylcholine levels induce a compensatory increase in gut microbiota urease activity and ammonia production. By upregulating presynaptic Cav2.1 calcium channels in enteric neurons, ammonia enhances calcium influx and restores acetylcholine release neurotransmission, revealing a microbiota-driven mechanism that preserves gut motility.

Out Now! Gut bacteria ammonia production restores acetylcholine neurotransmission and bowel motility #MicroSky

Decoding cancer across scales with metabolomics - Nature Reviews Cancer In this Review, Rowles and Patti present metabolomics workflows to study cancer across scales. They explore the nutrient demands of cancer cells and how those needs can be fulfilled through metabolic ...

Decoding cancer across scales with metabolomics www.nature.com/articles/s41...

The differential impact of three different NAD+ boosters on circulatory NAD and microbial metabolism in humans - Nature Metabolism A comparison of the effects of different NAD+ boosters is lacking. This clinical study compares the efficacy of the NAD+ boosters NR, NMN and Nam in increasing circulating NAD+ levels and analyses their effects on gut microbial metabolism.

RESEARCH | S Christen, B Cuenoud et al. (Nestlé Health Science):

Clinical comparison of the efficacy of three NAD+ boosters in increasing circulating NAD+ levels in humans 🧪

ChemEmbed: a deep learning framework for metabolite identification using enhanced MS/MS data and multidimensional molecular embeddings Abstract. Machine learning offers a promising path to annotating the large number of unidentified MS/MS spectra in metabolomics, addressing the limited cov

ChemEmbed: a deep learning framework for metabolite identification using enhanced MS/MS data and multidimensional molecular embeddings url: academic.oup.com/bib/article/...

Roses are red
Violets are blue
Microbes are awesome
Even when they're in poo

#microValentines

A Montréal, la présence d’un rouge-gorge venu d’Europe étonne et attire les foules Cet oiseau est commun en Europe mais absent outre-Atlantique. Plusieurs hypothèses tentent d’expliquer comment le passereau a pu ainsi s’égarer et traverser l’océan.

A Montréal, la présence d’un rouge-gorge venu d’Europe étonne et attire les foules

Enterococcus faecalis redox metabolism activates the unfolded protein response to impair wound healing E. faecalis EET generates ROS, which induces the UPR in keratinocytes, inhibiting in vitro migration.

We’ve discovered how the superbug E. faecalis prevents chronic wounds from healing.

It’s not a toxin. It’s metabolism.

The bacteria use extracellular electron transport (EET) to electrochemically generate ROS, effectively "freezing" skin cells in place.

doi.org/10.1126/sciadv.aeb5297

Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control - Nature Metabolism The microbial metabolite trimethylamine (TMA), the precursor of TMAO, which is associated with adverse cardiometabolic outcomes, is shown to have beneficial metabolic and anti-inflammatory effects in the host in the context of obesity.

RESEARCH | J Chilloux, @marcedumas.bsky.social et al. (Imperial College London)

The microbial metabolite TMA (precursor of TMAO) has beneficial metabolic and anti-inflammatory effects🧪

Are you interested in #metaproteomics? We have a senior scientist position in my lab focused on metaproteomics, and xenobiotic- #microbiome -host interactions. Check it out.
jobs.quadram.ac.uk/Details.asp?...

The gut microbiome and cancer: from tumorigenesis to therapy - Nature Metabolism This Review discusses the impact of the gut microbiota on cancer and on cancer therapy, highlighting the importance of developing microbiota-targeting strategies to improve cancer therapy outcomes

Reviews/Perspectives Top #Citations 2025: 🥉🧪

M Van Hul, P Cani @microbesity.bsky.social (UC Louvain) et al.

The gut microbiome and cancer: from tumorigenesis to therapy

Untargeted UHPLC-Q-Orbitrap Metabolomics Reveals Hormonal Suppression and Candidate Serum Markers as Evidence of Testosterone Misuse in Cattle #AnalMethods pubs.rsc.org/en/content/a...

Back in the day, I spent a lot of effort pointing out that many claims of lateral gene transfer between taxa were better explained by other phenomena, like gene loss, duplicaiton and deletion, convergence, bad informatics, etc 1/n

Evolution of rhizobial siderophore utilization via accessory xeno-siderophore receptors and flexible intake machinery for self-produced siderophores Abstract. Bradyrhizobium and Sinorhizobium are dominant soybean microsymbionts in acidic/neutral and alkaline soils, respectively. However, the molecular m

Evolution of rhizobial siderophore utilization via accessory xeno-siderophore receptors and flexible intake machinery for self-produced siderophores

academic.oup.com/ismej/advanc...

A commensal bacterium secretes effector proteins to establish population heterogeneity in the gut Zagieboylo and colleagues demonstrate that the human commensal Bacteroides thetaiotaomicron secretes two self-targeting proteins that induce heterogeneity within its own population. Differential expre...

#NatMicroPicks

Population Dynamics in gut Bacteroides 🦠

Gut commensals create population diversity by producing and responding to secreted effector proteins.

www.cell.com/cell-host-mi...

See you in less than 1 hour for the kickoff to the 2025 @isbscience.org Virtual Microbiome Symposium!

This year, we will explore microbial metabolites and their impacts on the host.

@flash-point.bsky.social will start things off at 9AM Pacific Time.

#ISBmicro2025

isbscience.org/events/2025-...

Spatial and morphological organization of mitochondria in neurons across a connectome Neuronal function depends on mitochondria, but little is known about their organization across neurons. Using an electron microscopy Drosophila connectome, we uncovered quantitative rules governing th...

Spatial and morphological organization of mitochondria in neurons across a connectome | Science www.science.org/doi/10.1126/...

Klebsiella ARO112 promotes microbiota recovery, pathobiont clearance and prevents inflammation in IBD mice Nature Communications - Here, the authors provide evidence of the biotherapeutic potential of Klebsiella ARO112 for gut inflammatory conditions by showing it accelerates pathobiont clearance and...

Thrilled to share that our new paper is out now in @natcomms.nature.com 🎉
Huge congrats to @vhrcabral.bsky.social and @karinaxavierlab.bsky.social on this major work.

We found that our Klebsiella ARO112 can break the antibiotic/inflammation cycle in an IBD model

Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control - Nature Metabolism The microbial metabolite trimethylamine (TMA), the precursor of TMAO, which is associated with adverse cardiometabolic outcomes, is shown to have beneficial metabolic and anti-inflammatory effects in ...

Delighted to see this paper out with @mrjulien.bsky.social and @marcedumas.bsky.social.

It's taken a lot of work/time to get this over the line, and adds to what we know about how microbe-derived metabolites - in this case TMA - influence host-associated processes.

www.nature.com/articles/s42...