#NatMicroPicks
A new way to defeat Mycobacterium! 🦠💉
Metabolic overactivation of the L‑histidine biosynthesis pathway in M. tuberculosis impairs its growth and infectivity, revealing a novel bactericidal mechanism for antimycobacterial drug discovery.
#MicroSky
www.nature.com/articles/s41...
#NatMicroPicks
Opportunistic Pseudomonas 🦠🌱
Root‑secreted coumarins can be exploited by Pseudomonas NyZ480, whose coumarin‑degrading genes enable opportunistic colonization that worsens plant iron deficiency and impairs overall plant fitness.
#MicroSky
www.nature.com/articles/s41...
#NatMicroPicks
Transmission dynamics of Oropouche virus 🌐
A comprehensive assessment of OROV transmission in 2023-24 epidemic in Manaus City & estimated OROV infections across Latin America and the Caribbean provides better understanding of the OROV burden
#MicroSky
www.nature.com/articles/s41...
#NatMicroPicks
Diet-microbiome analysis at population scale 💻🦠
Diet shaped gut microbiome composition and function analysed at species-level resolution might enabling long‑term predictions and personalized dietary intervention strategies.
#MicroSky #MicrobiomeSky
www.nature.com/articles/s41...
#NatMicroPicks
Microbial factor in cancer immunotherapy resistance 🦀🦠💉
Ligilactobacillus salivarius–derived indole-3-lactic acid suppresses anti-tumor T‑cell populations, driving resistance to anti‑PD‑1 therapy in ESCC
#MicroSky #CancerSky #MicrobiomeSky
www.cell.com/cell-host-mi...
#NatMicroPicks
Influenza in the sneeze 🤧🦠
A modular sampling tunnel captures, cultures, and sequences virus in human respiratory expulsions, revealing wide individual variation and preserved viral diversity in aerosols.
#MicroSky
www.cell.com/cell/fulltex...
#NatMicroPicks
Same destination, different routes 🍄🧫🧪
Following 10,000 generations, parallel evolution occurred in separate yeast species, but took different genetic routes driven largely by transcriptomic and trans‑regulatory differences.
#MicroSky
www.nature.com/articles/s41...
#NatMicroPicks
Vaccination boost! 🦠💉
A delayed booster given 18 months after the initial dose generates a stronger, more diverse, and long‑lasting high‑affinity antibody response to Ebola glycoprotein than a single vaccination.
#MicroSky
www.nature.com/articles/s41...
#NatMicroPicks
Host-microbe cycle in chronic kidney disease 🦠⚕️
Inefficient removal of indole derivatives due to kidney dysfunction in mice raises the levels of nitrate that in turn promote indole producing E. coli
#MicroSky
www.science.org/doi/10.1126/...
#NatMicroPicks
Live biotherapeutics for bacterial vaginosis 🚺🦠
A short course of vaginal Lactobacillus crispatus biotherapeutics after antibiotics safely achieved sustained colonization in many women recovering from bacterial vaginosis.
#MicroSky
www.cell.com/cell-host-mi...
#NatMicroPicks
From trash to treasure 🦠🔧♻️
Engineered E. coli convert the plastic PET to levodopa - a frontline medication for Parkinson’s disease.
#MicroSky
www.nature.com/articles/s41...
#NatMicroPicks
Engineered E. coli boosts tumour immunotherapy 🦠🔧💉
A synthetic arginine–nitric oxide (NO) circuit enables sustained intratumoral NO production that promotes vascular normalization and immune reprogramming in mouse models
#MicroSky
www.nature.com/articles/s41...
#NatMicroPicks
Sending evolution into overdrive 🔧🦠
A Φ29‑based DNA replication system in E. coli enables stable and targeted hypermutation achieving evolution of enzyme activities within days
#MicroSky
www.nature.com/articles/s41...
#NatMicroPicks
No-GMO enhanced Bt toxin 🦠🌱🪲
Naturally occurring 'sporesilk' matrix coating the Bacillus thuringiensis toxin crystals boosts insecticidal activity providing a non-GMO pest biocontrol.
#MicroSky
www.nature.com/articles/s41...
#NatMicroPicks
The versatile Acinetobacter baumannii! 🦠
The dreaded pathogen naturally occupies soil and airborne niches that underpin its recalcitrance and human contact may have shaped its evolution.
#MicroSky
www.nature.com/articles/s41...
#NatMicroPicks
Multi-kingdom microbial interplay in cancer 🦠🍄🦀⚕️
Candida albicans synergizes with Fusobacterium nucleatum in colorectal cancer offering a potential therapeutic target via L‑arginine disruption.
#MicroSky #CancerSky
www.cell.com/cancer-cell/...
#NatMicroPicks
Antibiotics in the long run ⌛💊🦠
Antibiotic use shows lasting associations with reduced gut microbial diversity for up to 8 years, indicating long-term impacts on the adult gut microbiome.
#MicroSky #MicrobiomeSky
www.nature.com/articles/s41...
#NatMicroPicks
A Microbial Atlas 🦠🗺️
MicrobeAtlas unifies >2 million microbiome samples into a resource that enables consistent cross‑study comparisons and ecological contextualization of both known and newly discovered species.
#MicroSky #MicrobiomeSky
www.cell.com/cell/fulltex...
#NatMicroPicks
Simulating a bacterium 💻🦠
A 4D whole-cell model of the minimal bacterium JCVI‑syn3A simulates its ~100‑minute cell cycle to reproduce experimental measurements and predict behaviours
#MicroSky
www.cell.com/cell/fulltex...
#NatMicroPicks
Therapeutic eye bacteria 🦠👁️🔧
Engineered eye‑colonizing bacteria deliver IL‑10 long‑term to reduce inflammation, and accelerate corneal wound healing.
#MicroSky
www.cell.com/cell-reports...
#NatMicroPicks
A microbial signature of health! 🦠⚕️
A large meta-analysis highlights the importance of previously unknown and uncultured gut bacteria in maintaining human health
#MicroSky
www.cell.com/cell-host-mi...
#NatMicroPicks
Fungi host invasion! 🍄🌱
Mechanism of fungal turgor generation, that aids mechanical host penetration by fungus could present new targets for disease control in plants
#MicroSky
www.science.org/doi/10.1126/...
#NatMicroPicks
Mpox transmission caught in action! 🐿️🦠🐒
A wild squirrel-to-mangabey interspecies transmission highlights the risk to the population that hunts these animals for food
#MicroSky
www.nature.com/articles/s41...
#NatMicroPicks
A broad respiratory vaccine! 🦠🫁💉
An intranasal liposomal vaccine combining TLR4 and TLR7/8 ligands with ovalbumin produced broad and durable respiratory protection in mice
#MicroSky
www.science.org/doi/10.1126/...
#NatMicroPicks
Aerobic archaeal-eukaryotic ancestor? 🦠🫁
The ancestor of eukaryotes may have combined hydrogen metabolism with aerobic respiration, shaping early cellular complexity.
#MicroSky
www.nature.com/articles/s41...
#NatMicroPicks
C. diff vaccine! 🦠💉
A protective mucosal vaccine formulation that provides sterilizing immunity to clear C. difficile from the host.
#MicroSky
www.nature.com/articles/s41...
#NatMicroPicks
FMT for cancers in clinic! 💩🦠🦀⚕️
Three different clinical trials report activity of faecal microbiota transplant against cancer
#MicroSky #CancerSky
www.nature.com/articles/s41...
www.nature.com/articles/s41...
#NatMicroPicks
It matters where cancer-associated bacteria are! 🦀💊
The spatial localization of bacteria associated with tumors dictates opposite immune outcomes - driving metastasis or triggering antitumour neutrophil activity
#MicroSky
www.cell.com/cell/fulltex...
#NatMicroPicks
Enhancing anti-fungals! 💊🍄
A natural‑product butyrolactol A restores caspofungin activity against intrinsically resistant Cryptococcus neoformans and multidrug‑resistant Candida auris
#MicroSy
www.cell.com/cell/fulltex...
