Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi Chen et al. identify the natural product butyrolactol A as an inhibitor of the phospholipid flippase Apt1-Cdc50, which it locks in a nonfunctional state. By disrupting membrane homeostasis and enhanci...

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Enhancing anti-fungals! 💊🍄

A natural‑product butyrolactol A restores caspofungin activity against intrinsically resistant Cryptococcus neoformans and multidrug‑resistant Candida auris

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