Bowie

GIP receptor agonism suppresses inflammation-induced aversion and food intake via distinct circuits Province et al. show that parabrachial CGRP neurons mediate aversion due to interleukin-1β (IL-1β) administration. Glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism blocks aversion and CGRP activation caused by IL-1β while potentiating its anorectic effect. Dorsal vagal complex GIPR mediates anorexia due to GIPR agonism but may be dispensable for anti-aversion.

GIP receptor agonism suppresses inflammation-induced aversion and food intake via distinct circuits

GIP receptor agonism suppresses inflammation-induced aversion and food intake via distinct circuits Province et al. show that parabrachial CGRP neurons mediate aversion due to interleukin-1β (IL-1β) administration. Glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism blocks aversion ...

Localization of the inflammation associated anti-aversive actions of GIPR agonism via sites distinct from those that suppress appetite in the DVC www.cell.com/cell-reports...

A gorgeous brindle hound stares lovingly at his mom hoping for a bite of whatever she’s eating

So sorry you’re going through this. Our path to getting our old dog Lewis’s lymphoma diagnosis was so incredibly stressful - fingers and toes crossed that you wind up at a manageable diagnosis and that Luigi feels better soon ❤️

A much needed argument against fatalism that is also clear eyed about our grim situation (and how much grimmer it could get!)

There are many problems with this statement from Director Bhattacharya.

(1) As @michaeldgreen.phd notes, applicants have no option to requests multi-year funding.

An applicant may request a front-loaded budget with more funding in early years with justification (may or may not be approved).

1/6

The world is a vampire...get yourself good colleagues.
Thanks to @jonesparker.bsky.social for the invite to Northwestern and to Jones and @lbeutler.bsky.social for having me and @jamiedroitman.bsky.social over for post-visit dinner!

The data also reinforce a message that should be clear: American leadership in science and medical research requires far more than getting across the line on top-line budget negotiations and will require continued vigilance to track how HHS treats applications and existing awards.

How many 50s of millions do you reckon you’re owed?

Thank you! I initially got interested in this in part because I’ve had IBD since I was a kid. Appetite loss is an early indicator of flares and it has fascinated and frustrated me for as long as I can remember :)

New work from the lab on how sickness reduces appetite. Turns out, it’s complicated :)

We focused on a single inflammatory cytokine, IL-1b, and even that reduces appetite via multiple mechanism.

Thanks to Nik Hayes for leading and sticking with this project and to everyone else who contributed!

Not gonna lie: I cried a little.

YES!!!!

To summarize:

Most important

Max Perutz was NOT an example of someone with a great idea who went against the establishment wisdom to solve an important problem that he had uniquely identified.

He was part of an organized team working on this problem. He got lots of help.

11/14

Previously shared: GLP-1 physiology and pharmacology along the gut-brain axis

This Review by @lbeutler.bsky.social summarizes proposed gut-brain and central mechanisms through which GLP-1 and its synthetic analogs regulate food intake and bodyweight: doi.org/10.1172/JCI194744

I learned and synthesized a lot writing this review for @jci.org and hope it helps others do the same.

GLP-1 physiology and pharmacology along the gut-brain axis

This Review by @lbeutler.bsky.social summarizes proposed gut-brain and central mechanisms through which GLP-1 and its synthetic analogs regulate food intake and bodyweight: doi.org/10.1172/JCI1...

This Little-Known Appeal Could Force Your Insurer to Pay for Lifesaving Care. Here’s How to File It. When a health insurer refuses to pay for your treatment, you may have the right to have the denial reviewed — and potentially overturned — by an independent provider. Here are six steps experts sugges...

Few patients appeal a health insurance denial, but a little-known process that requires insurers and plans to seek an independent opinion can force insurers to pay for what can be lifesaving treatment.

Here’s what experts say you need to know.

Thrilled to be accepted to @acnporg.bsky.social @npp-journal.bsky.social and look forward to future meetings!

Congrats to all new members!

Also, an annual reminder to keep applying if you didn't make the cut at #ACNP2026.

You’re doing better than me! I haven’t gotten past the error screen at login 😂. Guess I wasn’t meant to do this today.

Happy birthday/anniversary/new year!! Our party animals didn’t even make it to 9pm

Fighting for Breath: The FDA’s Lax Generic Drug Rules Put Her Life at Risk Lung transplant patient Hannah Goetz’s life depended on the generic version of the critical drug tacrolimus. It was supposed to be equivalent to the brand-name medication — but the FDA doesn’t always ...

When Hannah’s pharmacy began filling her tacrolimus prescription with a generic version, the lung transplant patient didn't know something very important:

Months earlier, an FDA-commissioned study concluded that this generic was not equivalent to the brand drug -- and that her life was at risk.

Only worse when you could’ve walked to your destination in like 30 min

Good luck! ❤️

Beautiful work! Congrats to all!

The one tidbit of unambiguously good news I heard about study section today is that it is moving back to zoom from teams.

Opinion | Cancer Patients Like Me Are Casualties of MAHA’s Hypocrisy

So proud of my dear friend Sam for writing this. So furious he has to go through it.

www.nytimes.com/2025/11/11/o...

Schumer and the Dems are about to teach Trump the lesson that they’ll cave whenever he abuses power to sufficiently hurt people.

ICE Abduction Inside Daycare: Press Conference YouTube video by U.S. Representative Mike Quigley

This morning, ICE unlawfully kidnapped a day care worker in front of parents and children.

We’re demanding accountability for every way that DHS is violating our rights, breaking the law, and acting with impunity. We must resist.

WATCH.

ICE isn’t going after the worst of the worst. This morning, they took a preschool teacher without a warrant IN FRONT OF CHILDREN in my district.

#ice #chicago