Phase 1 Study of Rezatapopt, a p53 Reactivator, in TP53 Y220C–Mutated Tumors | NEJM Rezatapopt is an investigational, first-in-class, oral, selective p53 reactivator that specifically binds to Y220C-mutated p53, which stabilizes p53 in its wild-type conformation and restores its f...

This latest phase I study in #NEJM of a first-in-class, ORAL! selective #p53 reactivator looks promising

Biomarkers that we were forced to study in med school are now potentially druggable!

www.nejm.org/doi/full/10....

Is #EV going to become a thing?

And by EV I mean enteral ventilation… not the car

www.cell.com/med/abstract...

@cellpress.bsky.social

Had the pleasure to join the Hong Kong Anti-Cancer Society charity dinner

#HKACS

🚨Alert! For all healthcare professionals interested in gastrointestinal cancers, the newly established Hong Kong Society of Digestive Oncology will be holding its Inaugural Scientific Symposium on the 13th September 2025.

forms.gle/FYacRHQFvckn...

#oncology #GI #digestive #cancer

Glad to have the opportunity to be a panelist and learn from Chinese and international experts on the management of #BRAF #V600E mutant colorectal cancers

#CRC #HKSDO #CUHKmedicine

Very nice presentations at the #HKASLD bimonthly scientific meeting by Dr Gloria Chan #TKOH and Dr Rex Hui #QMH HKU Medicine

#hepatology

Please join us virtually for our immunotherapy toxicity #IOTOX multidisciplinary #MDT team roundtable on #GI and #liver toxicities on 30 July 2025

Welcoming any healthcare professionals who are interested in the management of these adverse events!

Register now!

#oncology #oncogastroenterology

Great to meet Dr Min-Han Tan #Lucence at the oncology academic meeting #CUHKMedicine and to hear his insights on liquid biopsy in cancer care

Structured Exercise after Adjuvant Chemotherapy for Colon Cancer | NEJM Preclinical and observational studies suggest that exercise may improve cancer outcomes. However, definitive level 1 evidence is lacking. In this phase 3, randomized trial conducted at 55 centers, ...

A 3-year structured exercise programme after adjuvant chemo for colon cancer lead to:
- significantly longer disease-free survival (DFS) (HR 0.72; 95% CI, 0.55 to 0.94; P=0.02)
- better 5-year DFS (80.3% vs 73.9%)
- better OS at 8 years (90.3% vs 83.2%)

www.nejm.org/doi/full/10....

#gastrosky #oncsky #medsky

Redefining cancer care: the case for an onco-gastroenterology subspecialty - Nature Reviews Gastroenterology & Hepatology Onco-gastroenterology is defined as a collaborative subspecialty of Gastroenterology that is dedicated to the unique needs of individuals with or at risk of cancer, with a focus on maintaining and man...

Delighted to share our thoughts on the emerging discipline of #oncogastroenterology in @natrevgastrohep.nature.com

#CUHKMedicine
#GIoncology #oncology

www.nature.com/articles/s41...

Busy night! Sharing some insights on liver considerations in HCC care at #HKASLD

Followed by our local experience of BRAF #HKSDO

#CUHKMedicine

Alcohol‐Attributable Cancer: Update From the Global Burden of Disease 2021 Study The global burden of alcohol-attributable cancer in 2021 is increasing in the past two decades.

Happy to share our latest study on alcohol-attributable cancer. From 2000 to 2021, although the ASDR from alcohol-attributable cancer declined, the total number of deaths continued to rise. Efforts needed to address!

#APT #CUHKmedicine #GIoncology

onlinelibrary.wiley.com/doi/10.1111/...

Asia-Pacific Consensus on the Use of Artificial Intelligence in Colorectal Cancer Screening and Surveillance Artificial intelligence (AI) assisted colonoscopy has been widely investigated for colorectal adenoma and cancer detection and characterization. Howev…

Very happy to share our latest Asia-Pacific consensus on artificial intelligence and colorectal cancer screening and surveillance

www.sciencedirect.com/science/arti...

#AI #GI #CRC #CUHKMedicine

Hereditary Gastrointestinal Cancer Syndromes and Early‐Onset Gastrointestinal Cancers Click on the article title to read more.

Our editorial on hereditary GI cancer syndromes and early onset GI cancers is now out in the Journal of Gastroenterology and Hepatology #JGH

#CUHKMedicine #cancer #genetics #gastroenterology

onlinelibrary.wiley.com/doi/full/10....

Last in person CGS family meeting this observership #NCCS

#genetics #cancer

Enlightening talk on “Personalised Medicine in Future Healthcare” by Prof Snyder who gave the 5th James Best Distinguished lecture at NTU #LKCmedicine

Had a wonderful time and learnt a lot at the cancer genetics service #NCCS

Thanks so much #JoanneNgeow for letting me take a glimpse into the world of cancer genetics

#oncology #genetics #genomics

Having a drink with Prof Pierce Chow and Sunny Wong

Delighted to share my thoughts on Onco-Gastroenterology with the GI team #NUS

Happy to meet my mentor and coach of the @ascocancer.bsky.social
LDP Asia Pacific today at National Cancer Centre Singapore !

Great to run into the boss, Prof Ravindran Kanesvaran this morning at National Cancer Centre Singapore !

Today, the 28th February is Rare Disease Day

*facts*:
🧬 Around 80% of rare diseases are of genetic origin
👶🏻 70% of rare diseases start in childhood
🔎 More than 7,000 rare diseases identified
🎗️ 1 out of 5 cancers are rare

🔗 WHO: bit.ly/41aTCKY 

#WHOFides

WHO strengthens support for grassroots crowdsourcing campaign: a global movement of unity and solidarity What started as a grassroots initiative by a WHO staff member has grown into a global movement for health.

What started as a grassroots initiative by a WHO staff member has grown into a global movement for health.

Learn more about the #1Dollar1World campaign and get involved.

People have the power 👏
🔗 bit.ly/3QyEuC3

Thanks so much Sunny Wong for the opportunity to share about onco-gastroenterology with the GI team at TTSH!

#oncosky #gisky

Interesting to learn more about integrative medicine from the Transforming Cancer Care with Integrative Oncology Symposium (TCCIOS) at National Cancer Centre Singapore #NCCS #OncSky

Adipose tissue retains an epigenetic memory of obesity after weight loss - Nature Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...

I have a good memory

I mean my fat cells

@nature.com

www.nature.com/articles/s41...

A poster with graphic elements explaining how our differences benefit us all.

Ever heard of #genomics? It’s the study of all our DNA. By understanding the story of genomics we can unlock a world of possibilities for global health care.

Images and descriptions of what's available on NEJM.org this week

New in the February 13, 2025, issue of NEJM:

Colchicine in Acute Myocardial Infarction (CLEAR trial) nej.md/4i2U6dV

Routine Spironolactone in Acute Myocardial Infarction (CLEAR trial) nej.md/4ftkpIc

Cabozantinib in Advanced Neuroendocrine Tumors (CABINET trial) nej.md/3AYuEoI

#MedSky

Early-Onset Gastrointestinal Cancers and Metabolic Risk Factors: Global Trends From the Global Burden of Disease Study 2021 To explore the increasing incidence of gastrointestinal (GI) cancers and related risk factors in younger patients.We used data from the Global Burden …

Happy to share our latest publication in @mayoclinic.org Proceedings:

1. Huge burden of early-onset gastrointestinal (GI) cancers globally

2. Age-standardized death rates of early-onset GI cancers from metabolic risk factors ↑ in all subtypes

#OncSky

www.sciencedirect.com/science/arti...