My super department @warwicklifesci.bsky.social is hiring 6 assistant profs in the wake of recent retirements. We're looking for people in microbiology/infection, cellular disease / immunity; environmental biology; and plant/crop science. #MicroSky warwick-careers.tal.net/vx/lang-en-G...

Diversity-generating retroelements for programmable targeted hypermutagenesis - Nature Biotechnology Diversity-generating retroelements are engineered for directed evolution in E.coli.

🔈Paper out! We turned the most fascinating phage host-switch mechanism, diversity-generating retroelements, into a programmable mutagenesis tool, DGRec. You can perform targeted hypermutation of any 50-200bp sequence directly in vivo in E. coli www.nature.com/articles/s41...

I’m a Nobel Prize-winning immigrant. I can no longer recognize this country. Attacks on science and immigrants are destroying America.

Nobel Laureate Jack Szostak “This country has given me endless opportunities…: The America we inhabit today bears almost no resemblance to the country I chose all those years ago” newsletter.ofthebrave.org/p/im-a-nobel...

🚨 Please share this fully-funded #PhD #opportunity within your network!👇 👇

Only two weeks are left to apply!

@imperiallifesci.bsky.social @imperialsci.bsky.social @imperial-edu.bsky.social @imperialcollegeldn.bsky.social

Great work from Jo Sadler's group!!

Yes, of course!

Hi Barbara, in vivo (continuous) or in vitro? How long is the target region? Happy to chat

As scientists, asking ourselves if our direction of travel is the right one is the responsible thing to do. This is why I'm really pleased to share this article summarising our reflections on the current state of biobased approaches to manage #plastic waste.

www.nature.com/articles/s41...

Pls re-post: My department @oxfordbiochemistry.bsky.social are recruiting for several new faculty positions (links below). Broad search in molecular biology/biochemistry, across prokaryotes and eukaryotes. Interested in understanding life at the molecular level, this job might be for you!
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Fully endorse this view at least in prokaryotes. Someone once told me that "cells are bags of ribosomes making more ribosomes". It may be worth considering that at some point in multicellular evolution (of eukaryotes?) this was abandoned by a more organism-centric strategy

🚨🚨🚨LAST CHANCE!! - Closing tomorrow!!! 🚨🚨🚨

🚨JOB alert🚨

We have three (yes, THREE) 🌟lectureships🌟 advertised in the School of Biological Sciences, University of Bristol.

Broad remit, including #AnimalBehaviour & #GlobalChangeBiology

⏱️Deadline: 8th March 2026
🙏Please circulate widely

😊Come join us!

Full #job details: tinyurl.com/y3us95rc

One week left to apply to this PhD studentship!! Do not miss this opportunity!

💷 Fully paid tuition and stipend for 3.5 years
📅 Deadline 27th February
🇬🇧 Home fees (UK national / settled status)
🧫 ⚗️ ⚛️ Interdisciplinary team

London SynBio Network 14 London SynBio afterwork talks and networking event on Thursday 26th of January

Join us Feb. 26 at Imperial!
🧬 PromoterAtlas: decoding regulatory sequences across Gammaproteobacteria using a transformer model
Lucas Coppens (Biofoundry)

🌾 Resurrecting plant defence mechanisms to avoid crop pathogens
Imogen Binnian (Resurrect Bio)

tinyurl.com/2d52z38h

A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?

Excited to share our latest work in @science.org on a new small polymerase.
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Every EU project that I have been part of involving P. putida inevitably starts by asking: 'What strain of KT2440 are you using? Should we all be using the same?' And also inevitably we all turn to @vdlorenzo.bsky.social to obtain a sample of the holy original vial.

Join us in our crusade to make materials sustainable!

We are recruiting a PhD student (home fees) to work on an exciting project to decarbonise the nylon industry and create new biodegradable materials.

Info on how to apply here: www.imperial.ac.uk/school-of-co... (deadline 27th of February!)

Reposting this paper now with a working link! 😅 www.sciencedirect.com/science/arti...

Thanks for letting me know!

Juan Luis Ramos @eezcsic.bsky.social developed a KEIO-like Tn5 mutant collection in the early 2000s but not sure if it's preserved and accessible

Feel like doing a SynBio PhD in Spain? Check this offer, many fellowships available 👉🏻 lifehub.csic.es/synbio-cofund/

You are on the Epstein files! The impact factor must be stratospheric!!

"Are you not worried that engineered microbes can be released into the environment and eat all the plastic?" The answer is not really. Pleased to share our latest piece addressing this question by evaluating the current status of whole-cell plastic degradation: www.sciencedirect.com/science/arti...

Hierarchical buffering of cellular RNA polymerase II pools maintains transcriptional homeostasis RNA polymerase II (Pol II) abundance and transcriptional output are coordinated across diverse conditions to maintain mRNA homeostasis. To determine whether Pol II acts as a limiting factor for transc...

What happens when you suddenly remove half of an essential enzyme from cells? 🤔

We watched in real-time as cells deploy multiple backup strategies to buffer against changes in RNA Pol II abundance.

Our lab's new preprint 👇

bit.ly/4pyPgax

#CIBpapers

Researchers at the @cib-csic.bsky.social present a new bacterium capable of transforming plastic waste into high-value bioproducts

More info 🔗cib.csic.es/news/research/researcher...

New year resolution: develop the strength and technique to do ONE bloody muscle-up. Not a lot to ask. That at the back is the Bay of Cadiz. Not a bad place to start 2026. Happy New Year!!

Really happy to see this paper out. It looks like Santa had us on the nice list!! Congrats to all authors, it's been such a joy to be involved!

Manchester Institute of Biotechnology is looking for a new Professor. There are a few priority areas including microbial engineering (broadly defined, from pathways to cells to microbiomes). Closing 12 Jan.
Join us in the best city in the UK 😜
www.jobs.manchester.ac.uk/Job/JobDetai...

Quantitative profiling of millions of nucleotides reveals sequence-encoded interactions that govern plasmid propagation Plasmids are central to modern biotechnology, especially therapeutic development, yet their propagation in Escherichia coli remains difficult to predict. Although expression-induced burden is well und...

So you think your mammalian plasmids have nothing to fear from cloning and propagation in E.coli?
Quantitative profiling of millions of nucleotides by Tom Copeman will prove you wrong! Supervised with the amazing @proftomellis.bsky.social and AZ, now on BioRxiv:
doi.org/10.64898/202...

Using novel genomic tools to understand the evolution of Acinetobacter baumannii pathogenicity in clinical environments at University of Birmingham on FindAPhD.com PhD Project - Using novel genomic tools to understand the evolution of Acinetobacter baumannii pathogenicity in clinical environments at University of Birmingham, listed on FindAPhD.com

- Using novel genomic tools to understand the evolution of Acinetobacter baumannii pathogenicity in clinical environments

Supervisors: David Grainger, Katie Hopkins, Jessica Blair, Willem van Schaik

www.findaphd.com/phds/project...

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