#LKB1 loss in alveolar epithelial cells reduces #autophagy, induces #EMT, and drives #PulmonaryFibrosis via epithelial–fibroblast crosstalk, highlighting CAB39L‑LKB1 signaling as a potential therapeutic target in IPF. @unisouthampton.bsky.social
#OpenAccess: doi.org/10.1016/j.ge...
LKB1 acts as a nexus between metabolism and gene expression, acting via the SMARCA4-SWI/SNF complex to regulate gene expression in lung cancer. New in @frontiersmedia.bsky.social
doi.org/10.3389/fcel...
🔥 Hot paper from new investigators reveals that LKB1 mono- and bi-allelic loss increasingly reprograms the intestinal epithelium into a regenerative state characterized by autocrine EGF signaling and a predisposition towards serrated #ColorectalCancer development.
🔗 https://ow.ly/aXBj50Yfhem
This week's cover @thelancet.com
CIHR funding rate: 13.6%.
Early 2000s: 30%+.
Canada’s new $1.7B Impact+ program recruits talent — but without increased Tri-Council base funding, we risk further strain on an already stretched system.
We’re calling for $1B over 5 years.
Support here: tinyurl.com/33c5av46
15% of LUAD lacked TTF-1 expression
-> lower PD-L1 & more frequent KRAS and high-risk mutations, such as STK11, KEAP1, & SMARCA4
-> TTF-1 negativity stratified outcomes even among pts with high-risk mutations
Proanthocyanidins enhance antitumor immunity by promoting ubiquitin-proteasomal PD-L1 degradation via stabilization of LKB1 and SYVN1 @jci.org
www.jci.org/articles/vie...
This preprint maps synthetic lethal (SL) targets across 15 common cancer drivers using genome-wide CRISPR KO screens in isogenic cell line pairs plus a large-scale comparison to DepMap.
www.biorxiv.org/content/10.6...
What if “undruggable” cancer drivers are druggable indirectly?
New bioRxiv preprint: 15 CRISPR synthetic lethality screens + DepMap, then validation with clonogenic assays counted on GelCount.
ARID1A→GFPT1, STK11→MARK2, FBXW7→PKMYT1.
Read here: www.biorxiv.org/content/10.6...
Well, I don’t know what to say here. Discuss…
@cashwood.proteaglyco.com
pubs.acs.org/doi/10.1021/...
After a long review process, I'm excited that our paper is finally in print: www.cell.com/cell/fulltex...
TL;DR: We use CRISPR screens in iPSC-derived neurons to find a new tau E3 ligase and a relationship between oxidative stress, the proteasome, and tau proteolytic fragments.
More below 👇
As generalized before, most cancer promoting genes are enriched in embryonic neural/neural stemness cells, incl. KRAS/HER2/EGFR/STAT3.
They confer cancer cell with neural stemness, which determines tumorigenicity&pluripotency in cells. @pnas.org
www.pnas.org/doi/10.1073/...
STK11 mutations and deletions define a distinct subtype of cervical adenocarcinoma www.medrxiv.org/content/10.64898/2026.01...
Tumour suppressors LKB1 and SMARCA4 functionally interact to regulate gene expression of diverse biological processes in lung cancer www.biorxiv.org/content/10.64898/2026.01...
theconversation.com/ai-disruptio...
The knowledge factory model is outdated and ill-suited to meaningful learning. In this form of education, generative AI technologies will increasingly outperform students.
This review examines the roles of #LKB1/STK11 in #cancer, detailing its #TumorSuppressive functions, regulation via #AMPK signaling and #AdaptorProteins, and discusses the challenges of developing LKB1-targeted inhibitors. @westernu.bsky.social
#OpenAccess: doi.org/10.1016/j.ge...
Critical role for a high-plasticity cell state in lung cancer @nature.com @mskcancercenter.bsky.social
www.nature.com/articles/s41...
Academic publishing is now one of the most lucrative industries per unit of input
theconversation.com/when-science...
Single-cell RNA-seq is younger than the iPhone. 🤯 The first bona fide scRNA-seq transcriptomes were published in 2009 by Tang et al., who sequenced individual mouse cells and showed you could capture a whole transcriptome from a single cell. From “sci-fi” to standard tool in just over a decade...
From "The Tumor Suppressor Kinase LKB1: Metabolic Nexus" by Mohammed Bourouh, Paola A. Marignani. HIF1α promotes expression of glycolytic enzymes. Schematic representation of glycolysis and the pentose phosphate pathway (PPP). LKB1 phosphorylates and activates AMPK which then phosphorylates and inhibits RAPTOR, thereby inhibiting mTORC1. mTORC1 promotes HIF1α upregulation. Active HIF1α promotes expression of glycolytic enzymes (red) increasing glycolysis rate. HIF1α also promotes expression of 6PGD to shunt glucose-6-phosphate to the PPP to generate NADPH for REDOX balance and for synthesis of ribose-5-phosphate for nucleotide synthesis.
www.frontiersin.org/journals/cel...
Review: "The Tumor Suppressor Kinase LKB1: Metabolic Nexus"
LKB1 loss is associated with multiple malignancies and causes metabolic reprograming to increase glycolysis and lactate production, elevate hexosamine biosynthesis and glutamine metabolism.
www.nature.com/articles/s41...
Holloway et al. reveal that adaptor protein p11 is rapidly turned over by the proteasome and that its stability is tightly controlled through both ubiquitin-dependent and ubiquitin-independent mechanisms.
🔬New Preprint Alert 🔬 How is AMPK regulated by oxidative stress? We use functional imaging to uncover spatial regulation of AMPK activity during oxidative stress by LKB1 & CaMKK2. Combining imaging with proteomics & metabolomics, we find AMPK works to promote the cellular redox response.
www.sciencedirect.com/science/arti...
Authors combined targeted NGS with STAS and LVI scoring and organ-specific metastasis profiling within a single well-defined NSCLC cohort. This design allows them to directly link #STK11 mutation subtypes with distinct clinical and metastatic phenotypes. #LKB1
The authors also show in vivo protection against IgE-mediated anaphylaxis, hinting that AMPK agonists could be a real therapeutic avenue.
What’s striking is how zingerone works. By boosting LKB1/AMPK signaling, it reins in mast cell activation at the source, lowering Ca²⁺ influx, reducing granule release, and dampening the whole allergic cascade. It’s a metabolic lever with immunological consequences.
www.mdpi.com/1467-3045/47...
Zingerone, a ginger-derived compound, activates the LKB1/AMPK pathway to block IgE/FcεRI-dependent mast cell degranulation and anaphylaxis in models. Highlights AMPK agonists as potential anti-allergic therapeutics.
This review highlights the role of #LKB1 in #Tumorigenesis and its therapeutic relevance in #Oncology, offering new insights into targeted #CancerTherapy. @westernu.bsky.social #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
