#Immunology
Intelectin-2 is a broad-spectrum antimicrobial lectin
It binds glycans on mammalian cells (inducing mucin cross-linking) and on bacterial cells (leading to antibacterial activity)
@laurakiessling.bsky.social @kiesslinglab.bsky.social
⏰ Submit short talk abstracts and/or scholarship apps by Feb 4 at 11:59 PM for the Symposium on Tumor Microenvironment.
🎤 Speaker preview: youtu.be/lyK8XkYC8cI
🔗 Apply: keysym.us/KSTumorMicro26
@coussenslab.bsky.social @sandramcallister.bsky.social @laurakiessling.bsky.social
#KSTumorMicro26
Fun collaboration with @thexavierlab.bsky.social and Ribbeck groups to figure out how this human lectin plays multiple roles in controlling the #microbiome: stabilizing the mucus barrier and reducing bacteria that breach it. news.mit.edu/2026/protein... #glycotime
This meeting should be very fun as the program is quite diverse. (Even chemical biologists).
Join us for the 2025 Welch Conference on Chemical Research, “New Horizons in Drug Discovery,” Oct. 27-28 in-person or virtually. The event is completely free! Find more information here: welch1.org/conference/c...
Don’t miss Pamela Bjorkman’s keynote address at the 2025 Welch Conference about the need to combat future SARS-CoV-2 variants and new spillovers of SARS-like betacoronaviruses. Join in-person or virtually here: welch1.org/conference/r...
Looking forward to a great #chembio program hosted by @thewelchfoundation.bsky.social and organized by Kevan Shokat welch1.org/conference/c.... Great coincidence that Welch honorees are Stuart Schreiber and Pete Schultz.
Amazing news that the 5th Virtual @chembiotalks.bsky.social attracted 450 participants from 50 countries.
If you are as excited as we are, already mark next year's date (29th of September, 2026) in your calendars and make sure to suggest your favorite speakers!
#ChemSky #ChemBio #DrugDiscovery
Come join us at @stanford-chemh.bsky.social! I feel incredibly lucky to have launched my career here -- it is a fantastic place to do bold interdisciplinary science surrounded by creative & supportive colleagues. Applications are due 10/15/2025 -- DM me if you have questions about the search!
We are hiring!
If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland!
More information on www.epfl.ch/labs/gr-schu...
If you are at #FallACS2025 and like carbs, come by: My new title is Probing glycan recognition in health and disease.
Looking forward to talking today about some new ways of looking at what human lectins do. #FallACS2025
We are so grateful for resources to help us test key ideas about glycans and #Alzheimers disease. #glycotime🧪
To overcome challenges that #neurodegenerative diseases pose, MIT’s Aging Brain Initiative has awarded seed grants for 5 innovative research projects.
Congrats to Drs. Joseph Coughlin, Giovanni Traverso, Pattie Maes, Bin Zhang, @laurakiessling.bsky.social & @eboyden3.bsky.social ! bit.ly/4mVasaV
Opportunity in fragment-based design at Lilly (job available in 4 locations | UK: Bracknell | USA: Boston MA, Louisville CO, San Francisco CA) ref: R-86733 #FBD #FBDD #FBLD #CADD #CompChem #cheminformatics #ChemJobs #UKChemJobs #chemsky 🧪
careers.lilly.com/us/en/job/R-...
Brief victory celebration and NEW ASSIGNMENT
More than 27,000 comments posted regarding Schedule F implementation!
1/n
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)
The images show the ManLAM stays associated with cells in the macrophage even after a few days. Wish the macrophages were better at killing M. tuberculosis… We @kiesslinglab.bsky.social hope to use this labeling for better #TB diagnostics. #chemtwitter🧪
Stephanie along with Chi-Wang Ma, @lsoyoung.bsky.social @vicmarando.bsky.social, Greg Babunovic, @thebrysonlab.bsky.social used bioorthogonal labeling with oxaziridines to follow the glycan in infected macrophages. This is the first example of labeling a single type of glycan in cells (we think).
Lead author @ssmelyansky.bsky.social spearheaded a strategy to label a single sulfur-containing glycan called ManLAM on the cell envelope of the bacteria that cause #TB. news.mit.edu/2025/new-mol... or here: www.pnas.org/doi/10.1073/... 🧪 #glycotime @mitchemistry.bsky.social
We are so excited to see the cool science that will come out of your group #chemsky
ACTION ITEM-----ACTION ITEM
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
🙏 We need your help 🙏
The government continues to cancel grants at both NIH and NSF to censor science it doesn't like.
We're tracking terminations to organize and advocate. Please report your terminated grants:
NIH:
forms.gle/J2znQ7y7YpeP...
NSF: airtable.com/appGKlSVeXni...
w/ @noamross.net
We’re thrilled to feature an incredible lineup of plenary speakers at #Glyco27!
These experts will share cutting-edge insights and the latest advancements in glycomics across areas of health, including immunology, neuroscience and more!
Register today: glyco27.org/en/begin
@glycotime.bsky.social
These kinds of cuts are taking place when #TB rates are rising, including in the US. They dovetail with USAID cuts to #TB programs.
Job opportunity in SF to work at a small startup with the first PhD graduate of the Lieberman Lab!
A new means of selectively imaging the inner mycolate of mycobacteria using a compound that covalently modifies an enzyme intercepts to create a new intermediate with the Kim lab, @thebrysonlab.bsky.social and the Bernhardt lab. #TB
Thanks to Ratmir Derda we have an articulate reply to:
www.science.org/doi/10.1126/...
putting glycans back into the picture! @laurakiessling.bsky.social @anneimb.bsky.social @carolynbertozzi.bskyverified.social @molinarotony.bsky.social @dbojar.bsky.social @siglecdude.bsky.social
This is really beautiful research showing how the glycocalyx changes with aging and its impact on the blood-brain barrier.
Melanie Samuel
For the Idaho Statesman 🥔, Professor Melanie Samuel explains how science funding drives cures for diseases like Alzheimer’s and cancer— and the devastating impact of mass firings in Health & Human Services.
Happy Homecoming 🧪🧬🔬🏠
www.idahostatesman.com/opinion/read...