From earlier this week: Do cells of different lineages age differently?
doi.org/10.1172/JCI1...
Sundeep Khosla & team compare the senescence phenotype of mesenchymal versus immune cells from murine bone and bone marrow, revealing important differences between them.
Historic 1994 influenza vaccine cohorts define breadth of antibody and B cell responses toward future influenza A and B viruses | Science Translational Medicine www.science.org/doi/10.1126/... 🧪
Any immunologists looking for a 1yr staff scientist job in NC?
I’m not sure if I’m staying at UNC past 2027 but I’m feeling the weight of accumulating experimental backlog.
Ideally already in the area, experienced in T-cell assays like IFNg ELISpot, ICS, MHC multimer flow, &c
'Using single-telomere & sc analyses combined with mathematical modeling, we identify a threshold length at which telomeres switch into dysfunction. A single shortest telomere below the threshold length is necessary & sufficient to trigger the onset of replicative senescence in a majority of cells'
Strain-specific differences in the response to egg-derived versus recombinant protein influenza vaccines www.biorxiv.org/content/10.64898/2026.02...
Thank you for listening to your constituents!
Interesting, I thought there would be a section about building impenetrable berms in the bike lane at every corner to render the cleared lanes useless?
Massive resource!
Followed you for sf stuff and now you're sharing an amazing immunology paper that inspired my current research!
Kynurenine pathway dysregulation plays a key role in so many different conditions (including aging). IDO/TDO inhibition has not worked out well so far, but this paper suggests some other targets.
You should correct your post. it's phone footage and that's an important distinction in this context
Wdym ritualistic? Like in mice?
So cool
I've been successfully using Burton's buffers with dawn and no Triton for staining an endosomally localized membrane protein.
If you really optimized the vax formulation mRNA is not gonna make anything better imo.
The @ragoninstitute.bsky.social is launching a new faculty search for a computational immunologist! Applications are open now and reviewed on a rolling basis. Please share broadly with your networks! #immunosky
www.nature.com/naturecareer...
Plasma-localized IgG glycosylation is dynamically altered by the endothelium
www.pnas.org/doi/10.1073/...
A common progenitor gives rise to fibroblastic reticular cells and vascular smooth muscle cells in murine lymph nodes @jem.org
rupress.org/jem/article/...
B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes www.biorxiv.org/content/10.1101/2025.10....
Autoantibody origins in lupus and in relapse post CAR-T therapy www.biorxiv.org/content/10.1101/2025.10....
Cooler techniques available every day!
Could it be??
Enhanced human antigen-specific B cell responses using in vitro 3D tonsil cultures containing stromal cells www.biorxiv.org/content/10.1101/2025.09....
In the US it is called “Dawn”. We haven’t tried this, but the U.K. and Belgian brands both work fine. If you try Dawn please let us all know!
Just take a look. The Foxp3 fix/perm kit is good for TFs, but kills endogenous GFP. The eBio preserves GFP, but is incomplete at allowing TF staining. Burton's Best Buffer is as good as the best under all conditions (except phospho-flow), and preserves dye integrity too.
Plus it is dirt cheap. 🎤
PRDM1 shapes germinal center B-cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition www.biorxiv.org/content/10.1101/2025.08....
Hard not to get excited about his passion
Modulation of B cell receptor activation by antibody competition @cp-cellreports.bsky.social
www.cell.com/cell-reports...
Isolation of genetically diverse influenza antibodies highlights the role of IG germline gene variation and informs the design of population-comprehensive vaccine strategies www.biorxiv.org/content/10.1101/2025.07....