St. Jude scientists led a multi-institute collaboration to create PanNDA, a first-of-its-kind atlas mapping proteomes across six neurodegenerative diseases and more than 10,000 brain proteins. PanNDA can be used as a resource to advance diagnosis and treatment. https://ow.ly/ryy450YxEVb

A study of gene expression in the living human brain - Molecular Psychiatry Molecular Psychiatry - A study of gene expression in the living human brain

🤯 Postmortem vs Living brain
Due to the unavailability of brain tissue from living people, most such studies are performed using tissue from postmortem brain.
"Expression levels differed significantly for nearly 80% of genes,"🤯
www.nature.com/articles/s41...

Midkine attenuates amyloid-β fibril assembly and plaque formation - Nature Structural & Molecular Biology Zaman, Yang and Huang et al. demonstrate MDK’s suppressive effect on amyloid-β and its impact on amyloid burden and microglial activation in Alzheimer disease mice, highlighting its protective role in...

Excited to share our new paper in Nature Structural & Molecular Biology! We show that midkine attenuates Aβ fibril assembly and plaque formation, highlighting a protective role in AD progression.
www.nature.com/articles/s41...

Proteomic landscape of Alzheimer’s disease: emerging technologies, advances and insights (2021 – 2025) - Molecular Neurodegeneration The advancements of proteomics technologies are shaping Alzheimer's disease (AD) research, revealing new molecular insights and improving biomarker discovery. Here, we summarize major AD proteomics st...

Happy to announce that our new review on Alzheimer’s proteomics is out in Molecular Neurodegeneration: doi.org/10.1186/s130... #Alzheimers #Proteomics #MassSpec

Human and mouse proteomics reveals the shared pathways in Alzheimer’s disease and delayed protein turnover in the amyloidome - Nature Communications This study maps proteomic changes in Alzheimer’s mouse models, identifying shared pathways with humans, amyloid-driven protein turnover, and proteome-transcriptome differences, offering insights into ...

Excited to share our new paper! We mapped proteomic changes in AD mouse models, revealing shared pathways with human AD and delayed protein turnover in amyloid plaques. Read more: www.nature.com/articles/s41... #MassSpec #Proteinturnover #AlzheimersResearch #omics #proteomics