Human DHX29 detects nonoptimal codon usage to regulate mRNA stability Synonymous codon usage controls global gene expression in both prokaryotic and eukaryotic species. Nonoptimal codons are known to induce mRNA decay; however, the underlying molecular mechanism remains...

Human DHX29 detects nonoptimal codon usage to regulate mRNA stability | @science.org www.science.org/doi/10.1126/...

Unstructured transcription factor interactions enable emergent specificity How intrinsically disordered regions (IDRs) influence chromatin binding and nuclear organization of transcription factors (TFs) remains unclear. We employed proximity-assisted photoactivation (PAPA), ...

Unstructured transcription factor interactions enable emergent specificity | @science.org www.science.org/doi/10.1126/...

Soaking up destructive signals A structure-based approach identifies bacteriophage proteins that block bacterial immunity

Soaking up destructive signals | @science.org www.science.org/doi/10.1126/...

Structural modeling reveals phage proteins that manipulate bacterial immune signaling Immune systems in animals, plants, and bacteria often rely on intracellular nucleotide signaling, which viruses can block by sequestering or degrading these signals. We identified structural and bioph...

Structural modeling reveals phage proteins that manipulate bacterial immune signaling | @science.org www.science.org/doi/10.1126/...

🦖🦖🦖 @science.org 🦕🦕🦕

Evolution of error correction through a need for speed Kinetic proofreading is a class of error-correcting mechanisms in biology that expend energy to avoid mistakes during replication, transcription, and translation. Proofreading is typically assumed to ...

@science.org Evolution of error correction through a need for speed | Science #evolution 🧬🔬 www.science.org/doi/10.1126/...

Keeping cells fit Fragments of aberrant cytoplasmic mRNA pair with nuclear RNAs to augment transcription

@science.org Keeping cells fit | Science www.science.org/doi/10.1126/...

Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation Transcriptional adaptation (TA) is a genetic robustness mechanism through which mutant messenger RNA (mRNA) decay induces sequence-dependent up-regulation of so-called adapting genes. How cytoplasmica...

@science.org Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation | Science www.science.org/doi/10.1126/...

RNA comes close to copying itself Some RNA molecules can create their own mirror images, suggesting similar molecules could have sparked life

RNA comes close to copying itself | Science www.science.org/doi/10.1126/...

@science.org A small polymerase ribozyme that can synthesize itself and its complementary strand | Science www.science.org/doi/10.1126/... #RNA #ribozyme #evolution

Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries Eukaryotic gene expression is orchestrated by RNA polymerases (RNAPI, II, and III) and associated factors, yet their real-time dynamics remain obscure. Using single-molecule tracking in living yeast, ...

🧬🔬🎥 @science.org Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries | Science www.science.org/doi/10.1126/...

Programmable genome editing in human cells using RNA-guided bridge recombinases Site-specific insertion of gene-sized DNA fragments remains an unmet need in the genome editing field. IS110-family serine recombinases have recently been shown to mediate programmable DNA recombinati...

🧬🌉Online @science.org Programmable genome editing in human cells using RNA-guided bridge recombinases | Science www.science.org/doi/10.1126/...

From sequence to function: Bridging single-molecule kinetics and molecular diversity Biological function is fundamentally determined by nucleic acid and protein sequence. Beyond encoding genetic information, nucleic acids also display complex physicochemical parameters that shape stru...

🧬Appearing today @science.org a Review - From sequence to function: Bridging single-molecule kinetics and molecular diversity | Science 🔬https://www.science.org/doi/10.1126/science.adv4503

Scientists turn cells’ most mysterious structures into spies on genetic activity Enigmatic ‘vaults’ can be engineered to eavesdrop on RNA, aiding cancer studies and more

@science.org Scientists turn cells’ most mysterious structures into spies on genetic activity | Science | AAAS www.science.org/content/arti...

A genetically encoded device for transcriptome storage in mammalian cells Understanding how cells make decisions over time requires the ability to link past molecular states to future phenotypic outcomes. We present TimeVault, a genetically encoded system that records and s...

🧬🔬@science.org A genetically encoded device for #transcriptome storage in mammalian cells | Science www.science.org/doi/10.1126/... @broadinstitute.org

Deep contrastive learning enables genome-wide virtual screening Recent breakthroughs in protein structure prediction have opened new avenues for genome-wide drug discovery, yet existing virtual screening methods remain computationally prohibitive. We present DrugC...

@science.org Deep contrastive learning enables genome-wide virtual screening | Science www.science.org/doi/10.1126/...

🌱🍁🌻 #plantscience in 2025 @science.org 🎍🌽🌸👇

Same here—I rang in 2026 by changing “Papers to edit in 2025” to “Papers to edit in 2026.”

A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform Mammalian SWI/SNF chromatin remodeling complexes modulate DNA accessibility and gene expression; however, their genomic targeting mechanisms remain incompletely understood. Here, we identify SWIFT (SW...

🧬 @science.org A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform | Science www.science.org/doi/10.1126/... @ckadoch.bsky.social @danafarber.bsky.social @harvardmed.bsky.social @broadinstitute.org @hhmi-science.bsky.social 🔬 #chromatin #transcription #cancer 🧫

High-throughput single cell omics using semipermeable capsules Biological systems are inherently complex and heterogeneous. Deciphering this complexity increasingly relies on high-throughput single-cell omics methods and tools that efficiently probe the cellular ...

@science.org High-throughput single cell omics using semipermeable capsules | Science www.science.org/doi/10.1126/...

Multistep genomics on single cells and live cultures in subnanoliter capsules Single-cell sequencing methods uncover natural and induced variation between cells. Many functional genomic methods, however, require multiple steps that cannot yet be scaled to high throughput, inclu...

@science.org Multistep genomics on single cells and live cultures in subnanoliter capsules | Science www.science.org/doi/10.1126/...

Chromatin buffers torsional stress during transcription During eukaryotic transcription, Pol II must overcome nucleosome obstacles and, because of DNA’s helical structure, must also rotate relative to DNA, generating torsional stress. However, there is lim...

@science.org Chromatin buffers torsional stress during transcription | Science www.science.org/doi/10.1126/...

Chromosome shattering in cancer A protein that cuts double-stranded DNA contributes to chromosome scrambling in human cancer cells

🔬🧬@science.org #Chromosome shattering in #cancer | Science www.science.org/doi/10.1126/...

Chromothripsis and ecDNA initiated by N4BP2 nuclease fragmentation of cytoplasm-exposed chromosomes Genome instability, including chromothripsis, is a hallmark of cancer. Cancer cells frequently contain micronuclei—small, nucleus-like structures formed by chromosome missegregation—that are susceptib...

🧬🔬@science.org #Chromothripsis and ecDNA initiated by N4BP2 nuclease fragmentation of cytoplasm-exposed chromosomes | Science www.science.org/doi/10.1126/...

movie S6

@huabin-zhou.bsky.social @juliamaristany.bsky.social @kieran-russell.bsky.social @rcollepardo.bsky.social

How to Build A Synthetic Human Chromosome - Science Museum Blog Roger Highfield, Science Director, describes the first real stride toward writing human genomes from scratch.

blog.sciencemuseum.org.uk/how-to-build...

High-fidelity human chromosome transfer and elimination The synthesis of human genomes and other gigabase-scale genomes will require new strategies. Here, we realized key steps in our pipeline for building synthetic human chromosomes. We established: (i) t...

@science.org🧬High-fidelity human chromosome transfer and elimination | Science www.science.org/doi/10.1126/... @wellcometrust.bsky.social @mrclmb.bsky.social

A tale of two forms of cohesin in DNA repair Extrusive and cohesive cohesin cooperate to repair double-strand breaks in DNA

@science.org🧬Perspective A tale of two forms of cohesin in DNA repair | Science www.science.org/doi/10.1126/...

Cohesin drives chromatin scanning during the RAD51-mediated homology search Cohesin folds genomes into chromatin loops, the roles of which are under debate. We found that double-strand breaks (DSBs) induce de novo formation of chromatin loops in human cells, with the loop bas...

@science.org🧬Cohesin drives chromatin scanning during the RAD51-mediated homology search | Science www.science.org/doi/10.1126/... A thread by @albertomarin.bsky.social bsky.app/profile/did:...