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Posts by Sriram Neelamegham

Registration and abstract submissions will open in June! Bookmark the 2026 SFG Annual Meeting webpage and stay tuned for more information: https://lnkd.in/g75JFg-h

Registration and abstract submissions will open in June! Bookmark the 2026 SFG Annual Meeting webpage and stay tuned for more information: https://lnkd.in/g75JFg-h

SAVE THE DATE: The 53rd Society for Glycobiology Annual Meeting (SFG 2026) is heading to Atlanta! Join the global glycobiology community November 8–11, 2026 at the Emory Conference Center Hotel for four days of cutting‑edge science, collaboration, and discovery. lnkd.in/g75JFg-h
#SFG2026

1 month ago 12 7 0 0
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Uncovering bacterial pseudaminylation with pan-specific antibody tools - Nature Chemical Biology Pseudaminic acids (Pse) are a family of carbohydrates found within bacterial lipopolysaccharides, capsular polysaccharides and glycoproteins. Now, monoclonal antibodies have been developed that recogn...

🚨 Our new paper is out today in Nature Chemical Biology:
“Pan-specific antibodies to uncover bacterial pseudaminylation”
doi.org/10.1038/s415...

This is the product of a collaboration between many teams, led by @nickescott.bsky.social, @payneresearch.bsky.social and myself.

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2 months ago 24 8 2 3
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Major update for unilectin.unige.ch with now more than 2800 3D-structures with annotation, literature and details of interaction!! HumanLectome also up to date. Thanks to Boris Schnider at @sib.swiss and @glycoexpasy.bsky.social for super work. More exciting news soon with LectomeXplore upgrade

4 months ago 10 9 0 0
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Single-cell glycome and transcriptome profiling enabled by a library of anti-glycan antibodies
www.cell.com/cell-chemica...
@cp-cellchembiol.bsky.social

4 months ago 7 5 0 1
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GlycoEnzDB: A database of enzymes involved in human glycosylation Abstract. The glycan distribution on cells is governed by the activities of different families of enzymes that are together called “glycoEnzymes.” These in

GlycoEnzDB paper & website out in Glycobiology! ~400 enzymes with functions & pathways regulating human glycosylation. Thanks to Essentials editors for permitting textbook figures/text to train GPT. "GlycoEnzDB: A database of enzymes involved in human glycosylation": academic.oup.com/glycob/artic...

5 months ago 2 0 0 0

Sweet new #glycotime science out of the Huang lab looking at roles of glyco in the placenta.🧪🧪

5 months ago 7 3 0 0
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Hi bluesky! I'm very happy to share our new article out now in #ScienceAdvances! Gangliosides modulate extracellular vesicle secretion, with implications for neurodegenerative disease and other conditions with altered ganglioside levels.

www.science.org/doi/10.1126/...

#glycotime

5 months ago 1 1 1 0
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📢 Join us for the next GlySpace Alliance Webinar!

🗓️ Tuesday, November 18, 2025 | 10 AM ET
🎙️Dr. Rene Ranzinger presents: “New Features and Tools in GlyGen v2.9”
🗒️Details: wiki.glygen.org/GlySpace_All...

🔗 Join our mailing list: docs.google.com/forms/d/e/1F...

#glycotime #glygen #researchtools

5 months ago 2 2 0 0
Glycogang member Glucose flying on a broomstick as a witch with candy

Glycogang member Glucose flying on a broomstick as a witch with candy

Happy Halloween from GIA. Enjoy a free #glycotime treat. Sign up for next week’s #GIA2025 Symposium today.

glyco-alberta.ca/gia2025/

5 months ago 2 1 0 1
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The countdown is on! With GIA2025 less than 3 weeks away, we’d like to introduce our Keynote Speakers that we will have the privilege of hosting this year. First is Dr. Sriram Neelameghan from the University at Buffalo whose lab studies the area of Systems Glycobiology. @neel-lab.bsky.social

6 months ago 4 3 1 1
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UBC enzyme technology clears first human test toward universal donor organs for transplantation - UBC News UBC-developed enzymes successfully converted a kidney to universal type O for transplant, marking a major step toward faster, more compatible organ donations.

Just on time for my intro lecture on #glycotime in 3D ⤵️🎉

The first successful human transplant of a kidney converted from blood type A to universal type O used special enzymes developed by the team led by Prof Stephen Withers and Prof Jayachandran Kizhakkedathu at UBC

news.ubc.ca/2025/10/univ...

6 months ago 19 9 1 2
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a group of gnomes are sitting around a table in a cartoon ALT: a group of gnomes are sitting around a table in a cartoon

🚨 Don't Miss These Dynamic Workshops at the SFG 2025 Annual Meeting! 🚨

Workshops and satellite sessions start on Sunday, November 9 and continue over lunch on Monday, November 10.

For all details and registration check out the programme at a glance ⬇️

sfg.memberclicks.net/2025-annual-...

6 months ago 3 3 0 0
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Assistant Professor/Associate Professor, Oral Biology The University at Buffalo School of Dental Medicine (SDM) invites applications from qualified early- to mid-career oral health scientists and/or clinician-scientists for a full-time tenure track acade...

❗️❗️❗️👄👄 #MOUTH 👄👄 🦷🦷 #TEETH 🦷🦷 💧💧 #SALIVA 💧💧🦠🦠 #MICROBIOME🦠🦠 🍭🍭 #glycotime 🍭🍭 ❗️❗️❗️

❗️We are hiring❗️Check out this full-time tenure track academic faculty position in the #UBSDM's Department of Oral Biology.

ms.spr.ly/6045sKrT9

8 months ago 2 3 0 0
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Trump administration blocks NIH from awarding any research grants and contracts The order applies to the entirety of new and, possibly, ongoing research grant dollars that go to universities and academic medical centers.

“… immediately halt the issuing of research grants, research and development contracts, and training awards during a “pause” of unspecified duration. “

www.statnews.com/2025/07/29/t...

8 months ago 0 1 1 0
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GLYCAN ATLASSING: NANOSCALE ANALYSIS OF GLYCOCALYX ARCHITECTURE ENABLES FUNCTIONAL TRACING OF CELL STATE 🍭🔬🧬
Don’t judge a book by its cover - judge a cell by its cover! We can now trace how cell state is encoded in glycocalyx state. #glycotime #microscopy

www.biorxiv.org/content/10.1...

11 months ago 22 11 8 2
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Ångström-resolution imaging of cell-surface glycans - Nature Nanotechnology By combining bioorthogonal metabolic labelling and resolution enhancement through sequential imaging of DNA barcodes, the molecular organization of individual sugars in the native glycocalyx has been ...

New paper online:

Ångström-resolution imaging of cell-surface glycans.

The molecular organization of sugars in the native #glycocalyx has been resolved at 9 ångström using bioorthogonal metabolic labeling and #superresolution imaging of DNA barcodes.

#Glycotime

www.nature.com/articles/s41...

8 months ago 37 19 2 4
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Protein engineering strategies to develop lectins by design Abstract. Glycans regulate a wide array of biological processes, making them central to studies of cell biology. Thus, it is essential to characterize the

Happy to share 3rd paper in a series on glycoT engineering. Prior work in Small (pubmed.ncbi.nlm.nih.gov/40417887) & Nature Commun. (pubmed.ncbi.nlm.nih.gov/40681527/), and most recent in Glycobiology: "Protein engineering strategies to develop lectins by design": academic.oup.com/glycob/artic...

8 months ago 1 0 0 0
Mammalian Cell Surface Display for High‐Throughput Protein Engineering of Glycosyltransferases You have to enable JavaScript in your browser's settings in order to use the eReader.

Sharing link to our paper on high throughput engineering of glycosyltransferases— you can use it to study structure-function relations, discover disease associated mutations, make super enzymes with unique properties etc.: onlinelibrary.wiley.com/share/VGWXBG...

9 months ago 0 0 0 0
Transformer-based Deep Learning for Glycan Structure Inference from Tandem Mass Spectrometry Glycans play critical roles in diverse biological processes, but their structural analysis by tandem mass spectrometry (MS/MS) remains a major challenge due to their branched structure and stereochemistry. Traditional computational methods, such as database searching, are constrained by the scope of existing libraries and can be computationally intensive. While recent deep learning models have advanced the field, they often struggle to capture the complex, long-range dependencies within MS/MS spectra required for accurate inference. To address these challenges, we present GlycoBERT and GlycoBART, novel transformer-based models for glycan structure prediction from MS/MS data. GlycoBERT, a sequence classifier, achieves 95.1% structural accuracy on test data, surpassing the current state-of-the-art deep learning model, CandyCrunch. However, classification-based methods are inherently limited to predicting structures present in the training data. To overcome this, we developed GlycoBART, a generative sequence-to-sequence model capable of de novo glycan inference. On independent validation datasets, both models demonstrate robust performance. Critically, when applied to an MS/MS dataset from human embryonic kidney cells, GlycoBART generated two de novo glycan structures absent from the training set, one of which is a novel structure not catalogued in major glycan databases. Together, GlycoBERT and GlycoBART establish a new benchmark for glycan analysis, offering a powerful framework that enables more accurate and comprehensive exploration of glycan diversity and discovery. ### Competing Interest Statement The authors have declared no competing interest. National Heart Lung and Blood Institute, https://ror.org/012pb6c26, HL103411

Link to our collaboration with Rudi Gunawan on using deep learning for glycomics: www.biorxiv.org/content/10.1...

9 months ago 3 1 0 0
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FEBS Press The H antigen (O blood group), the precursor to A and B blood groups, is expressed on human erythrocytes. Two novel monoclonal antibodies generated using sea lamprey immunization, Tn4-31L and OmcFL3-...

📢New article alert! 'Blood group O expression in normal tissues and tumors', just published in FEBS Journal, highlights findings using our lamprey-derived monoclonal antibodies towards specific H antigen epitopes.
Read at: febs.onlinelibrary.wiley.com/doi/10.1111/...
#glycotime #glycans #bloodgroups

9 months ago 5 2 0 0