#MICROBIOME

Gut microbiome clues may help spot Parkinson's disease in its earliest phase A new study suggests that shifts in the gut microbiome may occur before Parkinson’s disease is clinically diagnosed, raising the possibility of earlier detection in genetically at-risk individuals and even in seemingly healthy individuals. Study: Microbiome signature of Parkinson’s disease in healthy and genetically at-risk individuals. Image Credit: Kateryna Kon / Shutterstock In a recent study published in the journal Nature Medicine, researchers investigated whether gut microbiome data could be used to identify individuals who may be closer to Parkinson’s disease (PD) onset or progression, rather than directly predict future PD risk. The study used fecal metagenomics data from a cohort of 464 individuals, including diagnosed PD patients (n = 271), non-manifesting GBA1 variant carriers (GBA-NMC; n = 43), and healthy controls (HC; n = 150) to identify PD-specific microbiome alterations that may reflect a premanifest or prodromal PD state. Study findings revealed that a large component of the gut microbiome, representing slightly over 25% of microbiome abundance, in at-risk individuals (GBA-NMC cohort) exists in an intermediate state between health and disease. This microbial signature was also observed alongside similar PD-related microbiome alterations across three independent international cohorts, supporting the reproducibility of the PD-associated microbiome pattern across populations. These findings...

Gut microbiome clues may help spot Parkinson's disease in its earliest phase
->News-Medical | More on "Gut microbiome Parkinson's early detection" at BigEarthData.ai | #Microbiome #Disease #SoilHealth

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Cellulite and Belly Fat and Bikini Season, Oh My! (Cupping Therapy And Gua Sha Can Help You With This) ~~~~~ As you know if you’ve been following my blog, I am all about body positivity and self-acceptance as-is and without qualifiers.  That said, we all want to look and feel our best, donR…

Cosmetic Chinese medicine really can be a lot of fun, actually.

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‘Smart Underwear’ Measures Gut Gas for Microbiome Science Device snapped into underwear monitors flatus frequency in real time to set a new baseline for what’s typical and gain insight into microbiome activity.

‘Smart Underwear’ Measures #Gut Gas for #Microbiome #Science

www.medscape.com/viewarticle/...

#AIhealth #AI #HealthAI #MedTech

A New Microbiome Test Aims to Help Law Enforcement Trace Poached Parrots Wildlife and customs officials working to stop the illegal parrot trade are in a tough spot. While it is against the law to capture wild parrots, buying and selling captive-bred individuals remains legal. Along with the high demand for parrots as pets, the difficulty in distinguishing captive-bred from wild individuals is one reason the intelligent birds remain among the most-trafficked animals in the world, according to the Convention on International Trade in Endangered Species. Tools exist for identifying illegally trafficked parrots, but they require specialized training, are time-consuming, and can be stressful for the animals, says Steven Janssen, a mobile veterinarian for the World Parrot Trust. As a result, officials mostly use a subjective process to determine which parrots warrant investigation for potential trafficking. “You base your decision on behavior. Is this an animal that is timid and starts screaming when you approach?” Janssen says. “Even for people who are into birds and know birds, this is difficult.” Now, researchers are refining a new method that could help law enforcement quickly and easily distinguish wild from captive-bred individuals. And it begins with a fecal sample. The tool is the result of a collaborative effort between scientists at the World Parrot...

A New Microbiome Test Aims to Help Law Enforcement Trace Poached Parrots
->Audubon | More on "Microbiome test tracking poached parrots" at BigEarthData.ai | #SoilHealth #Microbiome

Announcing the Fecal Microbiome Discovery Grant!

Empowering early-stage researchers to advance high-quality, reproducible fecal microbiome science from the very start.

Apply by June 14, 2026. Learn more: https://ow.ly/L7KU50YNcPq

#Grant #ResearchGrant #Microbiome #Research #Fecal #Transcriptomics

Close-up of a scientist using tweezers to place a sample in a petri dish, highlighting research for Wiley iMeta's top downloaded articles 2025.

Bioinformatics tools, amplicon pipelines, microbiome analytics — iMeta's most-downloaded papers of 2025 are the resources the global research community keeps coming back to 🌍

Read the collection 👇 https://ow.ly/ttgF50YMPO7

#Bioinformatics #Microbiome #Metagenomics

How your gut affects your health Emerging research suggests a link between gut health and other aspects of health, such as immunity, mental wellness and preventing some illnesses.

Gut health is whole-self health...

#GutHealth #Nutrition #Diet #Microbiome #EatWellLiveWell #HolisticHealth #SelfCare #HappyGutHappyLife 💕 #Wellness

Great session at the ITVA symposium!
Sensatec & AIT showcased advanced tools for site remediation 👇
#MIBIREM teams designing microbial consortia that can break down PAHs and chlorinated compounds✨

👉mibirem.eu/event/itva-contaminated-...
#Bioremediation #Microbiome #Soil

Brain Snack: One Type of Olive Oil Boosts Cognitive Power New research shows the benefits of non-processed olive oil to improve health and boost cognitive power in older people

Not all olive oil is equal!

"Brain Snack: One Type of Olive Oil Boosts Cognitive Power "

open.substack.com/pub/leadingb...

#health #brain #cognition #wellbeing #microbiome

Navigating multi-omic integration methods for human microbiome research Gilbert, J. A. et al. Current understanding of the human microbiome. Nat. Med. 24, 392–400 (2018). Wang, J. & Jia, H. Metagenome-wide association studies: fine-mining the microbiome. Nat. Rev. Microbiol. 14, 508–522 (2016). Marchesi, J. R. et al. The gut microbiota and host health: a new clinical frontier. Gut 65, 330 (2016). Xiong, R. et al. Multi-‘omics of gut microbiome-host interactions in short- and long-term myalgic encephalomyelitis/chronic fatigue syndrome patients. Cell Host Microbe 31, 273–287.e5 (2023). Wang, C. et al. Microbial risk score for capturing microbial characteristics, integrating multi-omics data, and predicting disease risk. Microbiome 10, 121 (2022). Ghaemi, M. S. et al. Multiomics modeling of the immunome, transcriptome, microbiome, proteome and metabolome adaptations during human pregnancy. Bioinformatics 35, 95–103 (2019). O’Sullivan, J. et al. Host–microbe multi-omics and succinotype profiling have prognostic value for future relapse in patients with inflammatory bowel disease. Gut Microbes 17, 2450207 (2025). Zhang, Y., Thompson, K. N., Huttenhower, C. & Franzosa, E. A. Statistical approaches for differential expression analysis in metatranscriptomics. Bioinformatics 37, i34–i41 (2021). Saenz, C., Nigro, E., Gunalan, V. & Arumugam, M. MIntO: a modular and scalable pipeline for microbiome metagenomic and metatranscriptomic data integration. Front. Bioinform. 2, 846922 (2022). Franzosa, E. A...

Navigating multi-omic integration methods for human microbiome research
->Nature | More on "Microbiome multi-omics integration methods" at BigEarthData.ai | #SoilHealth #Microbiome

Got a #microbiome event coming up?
If you are organising a seminar, workshop, conference session or public talk on the microbiome, you can submit it to World Microbiome Day for promotion.
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Habitual coffee intake shapes the gut microbiome and modifies host physiology and cognition This prospective study had three phases each evaluating cognition, stress, physical health, mood, immune function, gut microbiome, dietary intake, and metabolite composition (see Fig. 1 for design). Firstly, we compared non-coffee drinkers (NCD, n = 31) with coffee drinkers (CD, n = 31), then the CD group abstained from coffee for 14 days. Following this washout period, participants reintroduced either decaffeinated (n = 15) or caffeinated coffee (n = 16) for 21 days (Fig. 1A). Participants in the NCD group did not participate in any subsequent phases of the study. Overall, more females participated, and most participants were born per vaginum (Table 1). At baseline, CD participants consumed more caffeine daily than NCDs, and NCDs gave up more caffeine before the baseline visit (Table 1, Supplementary Data 1), though the level given up was substantially lower than what would be considered addictive. Alcohol consumption, education years, Childhood Trauma Questionnaire (CTQ) sub-scores, and predicted IQ (measured using the National Adult Reading Test (NART)) did not differ between groups (Table 1). When comparing these metrics between caffeinated and decaffeinated coffee drinkers during the intervention phase of the study, daily caffeine intake, the amount of caffeine abstained from, alcohol consumption, education years, CTQ...

Habitual coffee intake shapes the gut microbiome and modifies host physiology and cognition
->Nature | More on "Coffee gut microbiome cognitive effects" at BigEarthData.ai | #SoilHealth #Microbiome

🧠 The microbiota–gut–brain axis is reshaping our understanding of neurodegenerative diseases like Parkinson’s disease, Alzheimer’s disease & Amyotrophic

⏳ Abstract deadline closes TOMORROW!
📩 microbiomecongress.org/abstract-sub...

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#Dietary β-hydroxybutyrate sodium alters rumen #microbiome and nutrient metabolism in the #rumen epithelium of young #goats

doi.org/10.1016/j.ji...
#AnimalHealth #AnimalScience

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The MEIDIKE GENE Tongue Coating Self-Collection Kit enables easy self-collection for microbiome & genetic testing. Sterile swab + preservation tube ensures stable, reliable results.

Ideal for research, diagnostics, and health screening applications.

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How does food affect the gut microbiome? A new study shows that microorganisms in food may help maintain diversity in the gut. #Microbiome #MathematicalBiology
www.evolbio.mpg.de/3875249/news...

@florencebansept.bsky.social

Microbiome signature of Parkinson's disease in healthy and genetically at-risk individuals A total of 540 participants were included in the full analysis set for clinical data. Participants’ characteristics are shown in Table 1. Participants with PD (n = 314) included both carriers (n = 128) and non-carriers (n = 186) of GBA1 variants (Appendix A). The individuals without PD included healthy controls non-carriers of GBA1 variants (n = 175, HC) and non-manifesting GBA1 variant carriers (n = 51, GBA-NMC). When age and sex of GBA-NMC were compared to the other groups, no differences were detected. Participants with PD were significantly older than HC (P= 0.006) and more frequently males (P = 0.028). More than half of the HC participants were partners of people with PD, to mitigate the effect of diet or other lifestyle-associated variables on gut microbiome composition. Clinical profile of GBA-NMC To identify possible clinical elements that could stratify GBA-NMC for their risk of developing PD, we compared the severity of motor and non-motor symptoms between HC and GBA-NMC using a wide range of clinical scales and questionnaires (Table 1). We found worse motor symptoms in the GBA-NMC group, either subjectively reported (Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) part II, P = 0.0008, q = 0.0076)...

Microbiome signature of Parkinson's disease in healthy and genetically at-risk individuals
->Nature | More on "Parkinson's disease gut microbiome genetics" at BigEarthData.ai | #Healthy #SoilHealth #Microbiome #Disease

This is figure 2, which shows the association of microbiome alterations with clinical variables.

Changes in the composition of about a quarter of the gut microbial species in people with a variant of the GBA1 gene may indicate that those individuals are more likely to develop Parkinson’s disease, according to a study in Nature Medicine. go.nature.com/488tViC #microbiome 🧬🧪

Don't ruin your gut health.

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Gut microbiome can reveal risk of Parkinson's, scientists say Changes to microbes that live in the gut can identify people at greater risk of Parkinson’s disease long before symptoms develop, according to work that also raises hopes for new therapies. Researchers discovered signature changes in the gut microbiome that are more pronounced in people with a genetic risk for Parkinson’s and even more stark in those diagnosed with the disease. The signature could help doctors spot patients at risk of Parkinson’s years before they display clear symptoms and suggests that healthier diets and treatments that reshape the microbiome might prevent or delay the disease. Prof Anthony Schapira, the head of clinical and movement neurosciences at University College London and lead investigator on the study, said it was the first time a microbial signature in Parkinson’s patients had been seen in people with a genetic susceptibility but had yet to develop symptoms. The signature appears to become stronger as the disease progresses. “These same changes can be found in a small proportion of the general population that may put them at increased risk,” Schapira said. Cases of Parkinson’s have doubled in the past 25 years, with more than 8.5 million people globally now living with the condition. The disease causes...

Gut microbiome can reveal risk of Parkinson's, scientists say
->The Guardian | More on "Gut microbiome Parkinson's disease risk" at BigEarthData.ai | #Science #Microbiome #SoilHealth

Gut microbiome can reveal risk of Parkinson’s, scientists say Study shows signature changes more pronounced in people with genetic risk, raising hopes for new therapies

Changes to microbes that live in the gut can identify people at greater risk of Parkinson’s disease long before symptoms develop, according to work that also raises hopes for new therapies.

#Parkinsons #Microbiome

www.theguardian.com/society/2026...

As a medical school professor, this clinical trial changes how I think about Parkinso... https://www.youtube.com/@RobertLufkinMD
prebioticassociation.org/whats-the-latest-in-preb...

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To Thwart Pathogens, Researchers are Giving Beneficial Microbes What They Really Want UC San Diego researchers have developed a new method that allows precise modification of any microbiome with prebiotics, helping beneficial organisms outcompete dangerous pathogens.

@UCSDMedSchool.bsky.social researchers have developed a new method that allows precise modification of any #microbiome with #prebiotics, helping beneficial organisms outcompete dangerous #pathogens.

In #Microbiome

🚨Scale reliant mixed effects models enhance microbiome data analysis

🦠Introducing Scale-Reliant Mixed-Effects Models (SR-MEM): a general framework for mixed-effects modeling of microbiome sequence count data.

👉 doi.org/q3c5 #OpenAccess

Check out the latest issue of The Innovation Life!!! Volume 4, Issue 2 is now online!
www.the-innovation.org/life/article...
#lifesciences #3dbioprinting #evolution #precisionmedicine #microbiome #GeneEditing #artificialintelligence #Pyroptosis #OneHealth #alzheimersdisease #inflammatoryboweldisease

🧬Microbiota is transforming cancer therapy! From immune modulation to drug metabolism, microbes can enhance or inhibit treatment outcomes.

📢#GMC2026
Submit microbiomecongress.org/abstract-sub...
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Find A Health Coach: How To Find The Best Coach For What You Want To Accomplish (The Updates) You are ready for change (or, after a lecture at your doctor’s office about pre-diabetes, you know that change is in your be…

When it's time to lose weight... find someone who supports and never shames.

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Predicting competition & substrate preferences for targeted #microbiome alteration.

Microbial interaction & niche determination (MIND) infers microbial niches from mRNA translation to predict competition & guide interventions.

www.sciencedirect.com/science/arti... #microbiota #MicroSky