Check out the latest issue of The Innovation Geoscience!!! Volume 4, Issue 2 is now online!
www.the-innovation.org/the-innovati...
#geosciences #emissions #microclimatic #windfarm #digitaltwinearth #AtmosphericPollution #climatechange #carbondynamics #heatwaves #graphite #WaterAvailability
Check out the latest issue of The Innovation Life!!! Volume 4, Issue 2 is now online!
www.the-innovation.org/life/article...
#lifesciences #3dbioprinting #evolution #precisionmedicine #microbiome #GeneEditing #artificialintelligence #Pyroptosis #OneHealth #alzheimersdisease #inflammatoryboweldisease
Lakes worldwide are generally experiencing deoxygenation, while Chinese lakes are showing a countertrend of oxygen enrichment. Research confirms that eutrophication is the primary driver.
doi.org/10.59717/j.x...
#DissolvedOxygen #eutrophiclakes #ClimateWarming
This review summarizes the mechanisms of action and chemical modification strategies for oligonucleotides, highlights advances in receptor-mediated extrahepatic delivery systems, discusses recent progress in dual-targeting #oligonucleotide #therapeutics...
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#drugdiscovery
Neurotrophins, as a dynamic interface between neurobiology and metabolic regulation, may provide new insights into the mechanisms underlying obesity and expand potential intervention strategies.
doi.org/10.59717/j.x...
#neurotrophins #obesitymanagement
This study provides a visible-NIR double band fluorescence-PersL material rechargeable by red light, develops some basic laws in designing latent NIR PersL materials with perovskite-like structure...
doi.org/10.59717/j.x...
#bioimaging #Materials #calciumtitanate
Chen et al. developed a probiotic-based biohybrid integrating gastrointestinal stress resistance and ROS-scavenging capacity for effective IBD treatment.
doi.org/10.59717/j.x...
#inflammatoryboweldisease
Wang et al. recommend incorporating medical nutrition therapy into chronic disease insurance coverage, standardizing nutrition management training for primary care, and embedding #obesityprevention within the national chronic disease framework.
doi.org/10.59717/j.x...
#WeightManagement
In this work, Wang et al. develop a high signal-to-noise ratio optical sectioning structured illumination microscopy strategy for 3D imaging of biological samples ranging from millimeter-thick tissues to cellular dynamics.
doi.org/10.1016/j.xi...
#3Dimaging #opticalsectioning
This review comprehensively covers the biological mechanisms, screening methods, vector platforms, clinical progress in diverse cancers, and core bottlenecks of neoantigen vaccines.
doi.org/10.1016/j.xi...
#Neoantigen #Vaccine #clinicaltrials
The Innovation Coffee | 2D/Organic Material-based Electronic Synapses and Smart Sensing.
Speakers: Drs. Guanglong Ding, Zhenya Ding, Ke Chen
📅 Apr. 17, 2026 | 1:00 – 2:00 PM (UTC+8)
📍The Innovation Editorial Office, Shenzhen
VooV Meeting ID: 532-723-488
Attendance: In person or virtually!
#materials
@theinnovation.bsky.social #webinar: Encapsulating probiotics to protect intestinal health.
Speaker: Hao Wan, PhD
Date & Time: Apr. 18, 2026 | 21:00-22:00 (Beijing Time)
VooV meeting ID: 971-990-131
Join us this Saturday!
#probiotic #intestinalhealth
Check out our latest issue in The Innovation Drug Discovery!!! Volume 1, Issue 1 is now online!
www.the-innovation.org/the-innovati...
#DrugDiscovery #radiopharmaceuticals #tumormetabolism #precisionmedicine #drugdelivery #ArtificialIntelligence #computationaldesign #nanoparticles #GeneTherapy
This guideline provides a structured framework for the nonclinical evaluation of in vivo generated cell therapy products.
doi.org/10.59717/j.x...
#celltherapy #guideline #DrugDiscovery
The KRAS mystery: Why it acts differently across organs—Insights from the Mouse Cancer Cell line Atlas database reveals hidden evolutionary rules.
doi.org/10.59717/j.x...
#precisionmedicine #CANCEREVOLUTION
Targeted therapy for PTEN-deficient tumors remains a formidable clinical challenge. A study by Jean J. Zhao’s team reveals a novel mechanism of PI3Kβ phosphorylation, and this Commentary discusses its breakthrough value, offering new insights for precision #cancertherapy.
doi.org/10.59717/j.x...
This review synthesizes the molecular basis of diabetes pathogenesis, summarizes therapeutic evolution across drug classes, and highlights emerging technologies accelerating target discovery and translational development.
doi.org/10.59717/j.x...
#DrugDiscovery #diabetes
The Innovation Reviews is Coming!
The Innovation Reviews is an international, peer-reviewed, open-access journal that aims to publish high-impact review articles across all disciplines.
www.the-innovation.org/the-innovati...
#science #review #research
The rarest skill in the AI era isn’t mastering rules or intuition. It’s knowing which one the moment demands. A mahjong table explains why.
doi.org/10.1016/j.xi...
#metacapability #CognitiveDiversity
This commentary reveals how open science shatters data silos, balances data sharing with commercial incentives, and bridges AI-driven discovery to clinical validation—fundamentally reshaping the drug discovery ecosystem.
doi.org/10.59717/j.x...
#DrugDiscovery #openscience
This review systematically explains ferroelectric-based LIF neurons, covering the fundamental principles of neuronal operation, the implementation of neuronal functionalities, the key performance metrics, and strategies for performance optimization.
doi.org/10.59717/j.x...
#ferroelectric #neurons
This commentary highlights Jin et al.'s breakthrough: using light-induced H₂ heterolysis on Au/TiO₂ interfaces as "electronic scissors". This mechanism shatters thermal limits, achieving stable operation for >1500 hours.
doi.org/10.59717/j.x...
#catalysis #CarbonManagement
In this review, Xu et al. summarize current knowledge of #androgen biosynthesis, metabolism, and receptor signaling; delineate their systemic physiological and pathological roles; and explore emerging intersections with nutrition, metabolism, and immune regulation.
doi.org/10.59717/j.x...
#AI
Wang et al. developed self-sensing pneumatic artificial muscles and constructed a multimodal bioinspired mobile robot capable of adaptive locomotion and intelligent decision-making across diverse terrains.
doi.org/10.1016/j.xi...
#mathematics #physics #ArtificialMuscle #engineering
Gao et al. show that different stratospheric geoengineering strategies could significantly intervene AMOC evolution trajectories, through a positive feedback mechanism of latent heat acting in the Gulf Stream Extension region.
doi.org/10.59717/j.x...
#climatechange #Geoengineering
In this study, Fu et al. report the discovery and mechanistic elucidation of HF-4aa, a potent covalent inhibitor of TXNRD1 derived from MCR chemistry, which induces ferroptosis in triple-negative breast cancer.
doi.org/10.59717/j.x...
#TripleNegativeBreastCancer #drugdiscovery
The Innovation Coffee | AI-powered Intelligent Immuno-materials and Precision Repair.
Speakers: Drs. Long Bai, Liping Ouyang, Yong Xu, Ke Chen
📅Apr. 12, 2026 | 1:00 – 2:00 PM (UTC+8)
📍The Innovation Operations Headquarters
VooV Meeting ID: 682-888-452
Attendance: In person or virtually!
The RUNX1::RUNX1T1 pediatric AML model is a simple, robust tool for refining risk stratification. It effectively identifies a high-risk subset of patients with poor outcomes despite traditional favorable classification.
doi.org/10.1016/j.xi...
#acutemyeloidleukemia #medicine #immunecheckpoint
A novel catalytic radiopharmaceutical nanoplatform remodels tumor metabolism and induces systemic immune memory, thereby establishing a new research paradigm for overcoming the bottlenecks of solid tumor therapy.
#tumormetabolism #ferroptosis
The Innovation Coffee | A New Paradigm for Microbial #evolution and #taxonomy under Multi-omics Integration.
Speakers: Drs. Xiquan Yan, Taikui Zhang, Liwei Zhou, Zhenya Ding
📅Apr. 11, 2026 | 1:00 – 2:00 PM (UTC+8)
📍The Innovation Operations Headquarters
VooV Meeting ID: 902-741-238